Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes

Ntika, Stelia; Jois, Harshitha; Lång, Karin; Olsson, Christian; Franco‐Cereceda, Anders; Björck, Hanna M.; Krizhanovskii, Camilla

doi:10.3390/jcdd8110143

Cited by 1 publication

(1 citation statement)

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“…In contrast, other groups have found that CD4 + T cells in aortic aneurysms are predominantly IL-4-producing Th2 cells. Ntika et al ( 49 ) reported that no change was observed in the Th1 cytokines in the TAA group; however, cytokines associated with Th2 cells, such as IL-4, IL-5, and IL-10, were significantly altered in TAA patients compared to the control individuals.…”

Section: Discussionmentioning

confidence: 99%

Integrating Bulk Transcriptome and Single-Cell RNA Sequencing Data Reveals the Landscape of the Immune Microenvironment in Thoracic Aortic Aneurysms

Guo

Huo

Xiao

et al. 2022

Front. Cardiovasc. Med.

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Thoracic aortic aneurysm (TAA) is a life-threatening cardiovascular disease whose formation is reported to be associated with massive vascular inflammatory responses. To elucidate the roles of immune cell infiltration in the pathogenesis underlying TAA, we utilized multiple TAA datasets (microarray data and scRNA-seq data) and various immune-related algorithms (ssGSEA, CIBERSORT, and Seurat) to reveal the landscapes of the immune microenvironment in TAA. The results exhibited a significant increase in the infiltration of macrophages and T cells, which were mainly responsible for TAA formation among the immune cells. To further reveal the roles of immunocytes in TAA, we inferred the intercellular communications among the identified cells of aortic tissues. Notably, we found that in both normal aortic tissue and TAA tissue, the cells that interact most frequently are macrophages, endothelial cells (ECs), fibroblasts, and vascular smooth muscle cells (VSMCs). Among the cells, macrophages were the most prominent signal senders and receivers in TAA and normal aortic tissue. These findings suggest that macrophages play an important role in both the physiological and pathological conditions of the aorta. The present study provides a comprehensive evaluation of the immune cell composition and reveals the intercellular communication among aortic cells in human TAA tissues. These findings improve our understanding of TAA formation and progression and facilitate the development of effective medications to treat these conditions.

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Section: Discussionmentioning

confidence: 99%