Elevated glycated haemoglobin in non-diabetic patients is associated with an increased mortality in myocardial infarction

Chowdhury, TA; Lasker, Shawarna S

doi:10.1136/pgmj.74.874.480

Cited by 44 publications

(33 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher levels of fasting glucose and insulin and decreased insulin sensitivity themselves are significant risk factors for cardiovascular disease in both diabetic and nondiabetic populations (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Elevated levels of HbA 1c in nondiabetic individuals have been shown to be an independent risk factor for increased mortality after myocardial infarction (32), and HbA 1c was shown to be a continuously related factor for death from cardiovascular disease as well as all other causes in a population of ϳ5,000 men from the European Prospective Investigation into Cancer and Nutrition (33).…”

mentioning

confidence: 99%

Hostility, Race, and Glucose Metabolism in Nondiabetic Individuals

et al. 2002

View full text Add to dashboard Cite

OBJECTIVE -The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians.RESEARCH DESIGN AND METHODS -The relationship of hostility, as measured by a subset of the Cook-Medley hostility scale (CMHOST) inventory items, to various parameters of glucose metabolism were examined in a young, healthy sample of male and female AfricanAmerican and Caucasian volunteers. Fasting blood samples were collected during an inpatient admission, at which time the CMHOST was also administered.RESULTS -In the entire sample, the CMHOST was found to be significantly correlated with fasting glucose and insulin sensitivity, as measured by the homeostatic model assessment (HOMA). However, the relationship of hostility to these parameters of glucose metabolism was different in African-American and Caucasian subjects. Hostility was significantly related to fasting glucose in African-Americans and to insulin sensitivity and fasting insulin in Caucasian subjects. The relationship of hostility to insulin sensitivity and fasting insulin was partially dependent on BMI in Caucasians, but the relationship of hostility to fasting glucose was unrelated to BMI in African-Americans.CONCLUSIONS -Our data suggest that the relationship of hostility to measures of glucose metabolism is mediated differently in these two ethnic groups. Therefore, hostility seems to be part of a constellation of risk-related behaviors related to BMI in Caucasians but independently related to fasting glucose in African-Americans. Diabetes Care 25:835-839, 2002H ostility is a personality construct (1-4) that has been shown to be a risk factor for coronary artery disease (CAD). A number of studies provide support for hostility as a predictor of coronary events (5-8) and premature mortality from all causes (5). Hostility also has been found to be a correlate of subclinical atherosclerosis (9 -11), coronary risk profiles (12), and harmful health behaviors (13). The importance of hostility for health now has been generally confirmed in the literature (14).Although the mechanism by which hostility may increase risk of CAD is not known, it is generally believed that hostility may increase cardiovascular risk either through risk-related behaviors or neuroendocrine risk factors. These two alternatives have been conceptualized in terms of a health behavior model, a constitutional vulnerability model, and stress moderation models (15). The health behavior model suggests that hostility is associated with high-risk behaviors such as cigarette smoking, high caloric intake, and exercise habits. In contrast, the constitutional vulnerability model implies fundamental physiological differences for hostile individuals, perhaps at the genetic level, that place them at increased risk for disease. Stress moderation models suggest that hostile individuals may be constitutionally more reactive to stress, with their exaggerated stress response leading to an increased risk of disease. Furthermore, hostile...

show abstract

mentioning

confidence: 99%

Hostility, Race, and Glucose Metabolism in Nondiabetic Individuals

et al. 2002

View full text Add to dashboard Cite

show abstract

“…T he rate of for mation of glycated protein is considered to depend on the ambient concentration of glucose and half life of the protein [9] . However, there is convincing evidence that concentrations of nonenzymatically glycated protein are increased in many non-diabetic pathological states [10][11][12][13] . Elevated concentrations of glycated hemoglobin have been found in myocardial infarction, chronic renal failure, and nephrotic syndrome patients with normal blood glucose concentrations [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

“…However, there is convincing evidence that concentrations of nonenzymatically glycated protein are increased in many non-diabetic pathological states [10][11][12][13] . Elevated concentrations of glycated hemoglobin have been found in myocardial infarction, chronic renal failure, and nephrotic syndrome patients with normal blood glucose concentrations [10][11][12] . Similarly high concentrations of fructosamine are reported in non-diabetic chronic renal failure and rheumatic arthritis patients [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Increased plasma malondialdehyde and fructosamine in anemicH pyloriinfected patients: Effect of treatment

Vijayan

Sundaram²,

Bobby³

et al. 2007

WJG

View full text Add to dashboard Cite

“…But evidences in the literature have documented increased glycated protein levels in some nondiabetic pathological states, like iron deficiency anemia. Some authors have also found that on supplementation with iron therapy, there was a significant decrease in the levels of glycated haemoglobin [5]. Evidence has accumulated, which supports the hypothesis that the glycation reaction, apart from the traditional chronic hyperglycaemia ,can be modulated by the iron status of the patient.…”

Section: Introductionmentioning

confidence: 70%