Elevated glycosylated haemoglobin (HbA<sub>1c</sub>) is a risk marker in coronary artery bypass surgery

Alserius, Thomas; Anderson, R. E.; Hammar, Niklas; Nordqvist, Tobias; Ivert, Torbjörn

doi:10.1080/14017430801942393

Cited by 71 publications

(57 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to results of these studies, treatment of hyperglycemia in the postoperative period might reduce infection in the patients with DM [13]. Alserius et al [14] conducted a prospective study correlating HbA1c concentrations with infection rate and mortality outcomes in 605 patients. Rates of superficial sternal wound infection were significantly increased in patients with HbA1c ≥6% (13.9% HbA1c ≥6% vs 5.2% when HbA1c <6%, P=0.007).…”

Section: Discussionmentioning

confidence: 99%

Preoperative Hba1c level in prediction of short-term morbidity and mortality outcomes following coronary artery bypass grafting surgery

Arslan¹,

Memetoğlu²,

Kutlu³

et al. 2015

RusOMJ

View full text Add to dashboard Cite

Abstract:Objective -This study was conducted to determine whether HbA1c is a predictor of short term mortality and morbidity after coronary artery bypass graft operation. Methods -The coronary artery bypass graft operation was performed on the patients between January 2009 and January 2013. Each patient's medical record was retrospectively reviewed. The patients who were included in the study were evaluated in groups of 60. One group was comprised of nondiabetic patients, whose HbA1c level is below 6% (the control group 0), the other included diabetic patients with the HbA1c level is between 6-6.9% (the group 1) and the last group, group 2, included those patients with HbA1c level is equal or greater than 7%. Pre, peri and post operation data was compared. The deaths that occured in the first 30 days were evaluated as mortality and complications as morbitity. Results -While mortality was not observed in the control group, one incident was observed in group 1 and 5 in group 2, which corresponds to 1.7% and 8.3% respectively. The mortality ratio in the group with patients whose HbA1c was greater or equal to 7% found statistically significant compared to the control group (P=0.02). The following parameters were observed in group 2 and were found statistically significant: the need for dialisis (25%, P<0.01), atrial fibrillation (33%, P=0.01), revision due to bleeding (10%, P=0.18), cerebrovascular event (16,7%, P=0.01), duration of mechanic ventilation (19.5±21.6, P=0.06), duration of hospital stay (approximately 9.91±5.35 days, P=0.01), infection in scar (53%, P<0.01), mediastenit (11%, P=0.01) and urinary tract infection (10%, P=0.01) Conclusion -We concluded that in those diabetic patients that elective coronart artery bypass graft is applied, highly reactive HbA1c levels (HbA1c ≥7), may indicate morbitity in the early stages of post operation.

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative Hba1c level in prediction of short-term morbidity and mortality outcomes following coronary artery bypass grafting surgery

Arslan¹,

Memetoğlu²,

Kutlu³

et al. 2015

RusOMJ

View full text Add to dashboard Cite

show abstract

“…They found DM and postoperative blood glucose levels to be an independent risk factor for surgical site infection. Alserius et al investigated the relationship between HbA1c levels and postoperative infections (29) . Although not statistically signifi cant, DSWI incidence was higher in patients who had an HbA1c level of ≥ 6%.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Elevated HbA1c and Deep Sternal Wound Infection in Patients Undergoing Cardiac Surgery

Sevük¹,

Bilgiç²,

Yaylak³

et al. 2016

Kosuyolu Heart Journal

View full text Add to dashboard Cite

Introduction: Hyperglycemia is common in patients with and without diabetes mellitus (DM) following cardiac surgery. Intra-and postoperative hyperglycemia has been shown to be an independent risk factor for deep sternal wound infection (DSWI) after cardiac surgery. However, whether the preoperative chronic glycemic control is associated with the risk of DSWI remains controversial. Hemoglobin A1c (HbA1c) provides a measure of glucose control over the prior 2-3 months. The aim of this study was to evaluate the relationship between preoperative HbA1c levels and DSWI in patients with DM undergoing coronary artery bypass grafting (CABG). Patients and Methods:Records of patients who underwent elective on-pump CABG were retrospectively reviewed. A total of 180 patients with DM were included in the study. Patients were excluded if their blood glucose levels were not adequately controlled in the perioperative period. A total of 200 consecutive patients without DM were taken as controls.Results: Median HbA1c levels were signifi cantly higher in patients with DM [8.16 (7.2-10.4)] than in controls [5.49 (5-6)] (p< 0.001). There was no signifi cant difference in DSWI incidence between patients with DM and controls [5% (n= 9) vs. 2% (n= 4); P= 0.1]. Hospital (p= 0.01) and intensive care unit stays (p= 0.005) were signifi cantly longer in patients with DM. Conclusion:We found that DSWI was not associated with preoperative HbA1c levels in patients undergoing CABG. In addition, with adequate glycemic control in the perioperative period, our study demonstrated no signifi cant difference with regard to DSWI between patients with DM and controls.Key Words: Mediastinitis; coronary artery bypass grafting; hemoglobin A1c; diabetes mellitus; deep sternal wound infection Kalp Cerrahisi Yapılan Hastalarda Derin Sternal Yara İnfeksiyonları ile HbA1c Seviyeleri Arasındaki İlişki ÖZETGiriş: Kalp cerrahisi yapılan hastalarda, diabetes mellitus (DM)'lu hastalarda olduğu kadar diyabetik olmayan hastalarda da hiperglisemi ile sık karşılaşılır. Kalp cerrahisi sonrasında intraoperatif ve postoperatif hipergliseminin derin sternal yara infeksiyonu (DSYİ) için bağımsız risk faktörü olduğu gösterilmiştir. Ancak, preoperatif kronik glisemik kontrolün DSYİ ile ilişkisi tartışmalıdır. Hemoglobin A1c (HbA1c) geçmiş 2-3 aylık dönemdeki glukoz düzeyi hakkında bilgi verir. Bu çalışmanın amacı koroner baypas cerrahisi yapılan DM'li hastalarda, HbA1c seviyeleri ile DSYİ arasındaki ilişkiyi incelemektir. Hastalar ve Yöntem:Kliniğimizde kardiyopulmoner baypas altında koroner baypas operasyonu yapılmış olan hastaların kayıtları retrospektif olarak incelendi. DM'si olan ve perioperatif periyodda yeterli glisemik kontrol sağlanmış 180 hasta çalışmaya dahil edildi. DM'si olmayan koroner baypas cerrahisi yapılmış ardışık 200 hasta kontrol grubuna dahil edildi. Bulgular: Medyan HbA1c değerleri diyabetik hasta grubunda anlamlı olarak daha yüksekti [8.16 (7.2-10.4 vs 5.49 (5-6), p< 0.001]. DSYİ sıklığı bakımdan iki grup arasında istatistiksel olarak anlamlı b...

show abstract

“…Yapılan çalışmalarda HbA1c düzeyinin postoperatif enfeksiyon, miyokard infarktü-sü ve mortalite gibi advers olayların göstergesi olduğu gösterilmiştir (6,7). Bazal glukoz düzeyi postoperatif yara yeri enfeksiyonlarının derecelendirilmesinde yardımcı olabilir.…”

Section: Preoperati̇f Değerlendi̇rmeunclassified

Lung Cancer, Endocrınopathıes And Paraneoplastıc Syndromes

Akyay¹,

Selek²,

Tarkun³

2016

Toraks Cer Bult

View full text Add to dashboard Cite

Thyroid diseases and diabetes mellitus are the most common endocrine diseases. Lung cancer is also one of the most frequent cancer types observed worldwide. Therefore, diabetes and thyroid diseases are frequently observed in patients with lung cancer. The diagnosis and management of these diseases are important; hence, uncontrolled diabetes and thyroid diseases might increase postoperative mortality and morbidity rates. Endocrinologic paraneoplastic syndromes frequently accompany lung cancer. These diseases may be observed as the first sign of the disease or may cause a delay in treatment and an increase in mortality. In addition, lung cancer may metastasize to vital endocrine organs, causing hormonal insufficiencies that may be mortal if not treated. In patients with lung cancer, the treatment of comorbidities and coincidence diseases are as important as the treatment of primary diseases to decrease the mortality and morbidity rates.

show abstract

Elevated glycosylated haemoglobin (HbA_1c) is a risk marker in coronary artery bypass surgery

Abstract: HbA1c > or =6% was associated with an increased risk of postoperative superficial sternal wound infections and a trend for higher mediastinitis rate and significantly higher mortality three years after CABG.

Cited by 71 publications

References 26 publications

Preoperative Hba1c level in prediction of short-term morbidity and mortality outcomes following coronary artery bypass grafting surgery

Preoperative Hba1c level in prediction of short-term morbidity and mortality outcomes following coronary artery bypass grafting surgery

Relationship Between Elevated HbA1c and Deep Sternal Wound Infection in Patients Undergoing Cardiac Surgery

Lung Cancer, Endocrınopathıes And Paraneoplastıc Syndromes

Contact Info

Product

Resources

About

Elevated glycosylated haemoglobin (HbA1c) is a risk marker in coronary artery bypass surgery

Abstract: HbA1c > or =6% was associated with an increased risk of postoperative superficial sternal wound infections and a trend for higher mediastinitis rate and significantly higher mortality three years after CABG.

Cited by 71 publications

References 26 publications

Preoperative Hba1c level in prediction of short-term morbidity and mortality outcomes following coronary artery bypass grafting surgery

Preoperative Hba1c level in prediction of short-term morbidity and mortality outcomes following coronary artery bypass grafting surgery

Relationship Between Elevated HbA1c and Deep Sternal Wound Infection in Patients Undergoing Cardiac Surgery

Lung Cancer, Endocrınopathıes And Paraneoplastıc Syndromes

Contact Info

Product

Resources

About

Elevated glycosylated haemoglobin (HbA_1c) is a risk marker in coronary artery bypass surgery