Elevated heart rate as sympathetic biomarker in human obesity

Seravalle, Gino; Facchetti, Rita; Cappellini, Cecilia; Annaloro, Alessandra; Gelfi, Elia

doi:10.1016/j.numecd.2022.07.011

Cited by 10 publications

(3 citation statements)

References 33 publications

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“…In should be noted that in the population of the present study, as well as in a previous study [ 30 ], obese and severe obese subjects display elevated heart rate values during daytime and the nighttime periods. Since heart rate is a marker, although indirect, of sympathetic cardiovascular drive [ 34 ], this finding may indicate that even at pediatric age the obese state is already characterized by a neuroadrenergic activation. Finally, elevated circulating blood levels of adipokines, leptin, such as those described in obese subjects, and activation of the renin-angiotensin system may be regarded as additional non-mutually exclusive factors favoring the development of the obesity-related cardiac structural alterations, given the evidence that both leptin, adipokines and angiotensin II exert marked prohypertrophic effects on the heart [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

Association Between Elevated Body Mass Index and Cardiac Organ Damage in Children and Adolescents: Evidence and Mechanisms

Annaloro,

Invernizzi,

Aguilar

et al. 2024

High Blood Press Cardiovasc Prev

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Introduction Although a number of pathophysiological aspects of childhood obesity have been reported, few information are available on obesity-related cardiac organ damage. Aim The present study was aimed at assessing the impact of anthropometric, blood pressure (BP) and metabolic variable on cardiac structure and function in youth. Methods In 78 subjects aged 5–16 years attending the outpatient clinic of cardiovascular risk (Valencia, Spain) anthropometric and metabolic variables, clinic and ambulatory BP and echocardiographic parameters were assessed. Subjects were also classified according to the presence of insulin resistance. Results Subjects mean age (± SD) amounted to 12.03 ± 2.4 years and males to 53.8%. Ten subjects were normoweight, 11 overweight, 39 obese, and 18 severely obese. No significant difference in office and ambulatory BP was detected among different bodyweight groups. A significant direct correlation was observed between left ventricular mass index (LVMI) and obesity markers [body mass index (BMI): r = 0.38, waist circumference (WC): r = 0.46, P < 0.04 for both]. Left ventricular hypertrophy, relative wall thickness and left atrial diameter were significantly related to BMI and WC. In contrast, office and ambulatory BP were unrelated to other variables, and differences in LVMI among different BP phenotypes were not significant. When partitioning the population by insulin resistance, LVMI, adjusted for confounders, was significantly greater in the insulin-resistant group. Conclusions In children and adolescents characterized by different body weight patterns, weight factors “per se” and the related insulin resistance state appear to represent the main determinants of LVMI and left ventricular hypertrophy, independently on BP values and BP phenotypes. Supplementary Information The online version contains supplementary material available at 10.1007/s40292-024-00633-5.

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Section: Discussionmentioning

confidence: 99%

Association Between Elevated Body Mass Index and Cardiac Organ Damage in Children and Adolescents: Evidence and Mechanisms

Annaloro,

Invernizzi,

Aguilar

et al. 2024

High Blood Press Cardiovasc Prev

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“…Subjects of independent-type PVC in this study showed a trend of higher resting heart rate compared to fast-and slow-type PVC, which indicated the high sympathetic drive. 20,21 Patients with PVC were known to have higher sympathetic nervous activity than normal people. 22 However, spectral analysis showed the reduced LF component which characterizes decreased sympathetic tone variability in the heart.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability Analysis to Investigate Autonomic Nervous System Activity among the Three Premature Ventricular Complex Circadian Types: An Observational Study

2024

Acta Med Philipp

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Background and Objective. Premature ventricular complex (PVC) burden exhibits one of three circadian types, classified as fast-type, slow-type, and independent-type PVC. It is unknown whether PVC circadian types have different heart rate variability (HRV) parameter values. Therefore, this study aimed to evaluate differences in HRV circadian rhythm among fast-, slow-, and independent-type PVC.Methods. This cross-sectional observational study consecutively recruited 65 idiopathic PVC subjects (23 fast-, 20 slow-, and 22 independent-type) as well as five control subjects. Each subject underwent a 24-hour Holter Paper presentation -

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“…Развитие ожирения ассоциировано с инсулинорезистентностью и гиперинсулинемией, а гиперактивация СНС, в том числе при участии стрессорных факторов, повышает продукцию кортизола и ренина, что поддерживает метаболические нарушения и высокое АД, а в конечном итоге способствует ремоделированию сердца с формированием гипертрофии левого желудочка и его диастолической дисфункции. Увеличение ЧСС также характерно для пациентов с ожирением и АГ вследствие увеличенного объема циркулирующей крови и гиперактивации СНС [12].…”

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The role of stress and sleep disorders in the development of cardiovascular complications in patients with arterial hypertension: what is important for an internist to know? A review

Ионин

2023

Consilium Medicum

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This publication discusses the mechanisms underlying the development of arterial hypertension on the background of stress, discusses the current problems of blood pressure control in patients with stress-induced sleep disorders, the clinical features of patients with hypersympathicotonia as the main mechanism for the development of arterial hypertension and blood pressure variability in patients with comorbid pathology, a diagnostic algorithm, as well as presenting current recommendations in the strategy for choosing the optimal antihypertensive therapy with the possibility of personalized choice in various clinical situations.

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Elevated heart rate as sympathetic biomarker in human obesity

Cited by 10 publications

References 33 publications

Association Between Elevated Body Mass Index and Cardiac Organ Damage in Children and Adolescents: Evidence and Mechanisms

Association Between Elevated Body Mass Index and Cardiac Organ Damage in Children and Adolescents: Evidence and Mechanisms

Heart Rate Variability Analysis to Investigate Autonomic Nervous System Activity among the Three Premature Ventricular Complex Circadian Types: An Observational Study

The role of stress and sleep disorders in the development of cardiovascular complications in patients with arterial hypertension: what is important for an internist to know? A review

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