Elevated homeostatic model assessment of insulin resistance level increases the risk of acne

Nurhadi, Stefani; Praharsini, I Gusti Ayu Agung; Wiraguna, Anak Agung Gde Putra

doi:10.19100/jdvi.v3i1.83

Cited by 3 publications

(4 citation statements)

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“…Moreover, statistically higher mean HOMA-IR values were observed in the studies by Nurhadi et al [ 10 ] (an acne patient value of 2.63 vs. a non-acne patient value of 1.71), in the study by Emiroglu N et al [ 11 ] (2.87 vs. 1.63), and in the study by Del Prete et al [ 17 ] (1.7 vs. 1.1). In contrast, Cerman et al did not observe any connection between IR and acne vulgaris formation [ 16 ].…”

Section: Discussionmentioning

confidence: 85%

“…Furthermore, both acne and IR are observed in the course of syndromes such as HAIR-AN or hyperandrogenism (HA), IR, and acanthosis nigricans (AN) or polycystic ovary syndrome (PCOS) [ 6 ]. Several studies have revealed noticeably higher insulin serum levels and HOMA values among acne patients compared to the healthy controls; therefore, they indicate the importance of considering IR as a causative factor in acne formation [ 7 , 8 , 9 , 10 , 11 , 12 ]. However, as yet, no research has been conducted on the Polish population and more data are required in order to include IR evaluation as part of standard acne diagnostics and treatment options.…”

Section: Introductionmentioning

confidence: 99%

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Insulin Resistance in Patients with Acne Vulgaris

Gruszczyńska,

Sadowska-Przytocka,

Szybiak

et al. 2023

Biomedicines

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Acne vulgaris presents multifactorial pathogenesis, which may include insulin resistance. To investigate whether insulin resistance is a causative factor in acne vulgaris development, this cohort study and a systematic review were conducted. A cohort of 41 acne vulgaris patients and 47 healthy BMI-matched controls were recruited. Glucose and insulin fasting serum levels were obtained and the HOMA-IR was calculated; insulin resistance was diagnosed in cases with a HOMA-IR value over 2.1. The mean ± SD values for glucose fasting serum level were as follows: 94.88 ± 7.731 (mg/dL) in the study group and 79.51 ± 7.175 (mg/dL) in the controls (p < 0.001). The mean ± SD insulin fasting serum levels were 14.47 ± 6.394 (µIU/mL) and 11.83 ± 4.309 (µIU/mL) (p = 0.059), respectively. The HOMA-IR mean ± SD value calculated for the study group was 3.4 ± 1.49 and, in the control group, it was 2.34 ± 0.909 (p < 0.001). Out of 41 patients, 32 were diagnosed with insulin resistance (78%), and 26 of the 47 controls were diagnosed with IR (55%) (p = 0.026). An insulin resistance diagnosis was statistically more common among the acne patients, compared to the controls. In the articles reviewed in this paper, insulin resistance was found to be more frequent in acne vulgaris patients. Both our study and the papers analyzed in the review indicate that insulin resistance might be an independent factor in acne vulgaris development and should be considered when diagnosing and treating acne.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Insulin Resistance in Patients with Acne Vulgaris

Gruszczyńska,

Sadowska-Przytocka,

Szybiak

et al. 2023

Biomedicines

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“…To diagnose this irregularity, we need to calculate the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), which is based on a formula containing the levels of insulin and glucose fasting serum levels [ 37 ]. Acne vulgaris and IR seem to have similar mechanisms of development and the relationship between them has been noticed [ 17 , 18 , 35 , 38 , 39 , 40 , 41 , 42 , 43 ]. Western diet characterized by a high glycemic load and being rich in dairy products also causes overstimulation of the mTORC1 activity pathway and may cause acne [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Metformin Therapy for Acne Vulgaris: A Meta-Analysis

Szefler,

Szybiak-Skora,

Sadowska-Przytocka

et al. 2024

Pharmaceuticals

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Acne vulgaris is a common disease, which occurs in adolescents as well as adults and has a significant influence on the patient’s quality of life (QoL) in every aspect. Due to resistance to standard therapies, it has become necessary to prospect for new treatment strategies. It is important to highlight that the diagnosis and treatment of the underlying cause of acne such as metabolic and hormonal disorders may significantly improve the effectiveness of acne treatment. The correlation between Insulin Resistance (IR) and acne has been proven. Both disorders share many common occurrence factors and activation pathways. Metformin, an antihyperglycemic agent, seems to be a possible therapy option, not only because of its insulin sensitizing ability but also via plenty of additional effects of this medicine. While the efficiency of metformin therapy in patients with acne and Polycystic Ovary Syndrome (PCOS) is well explored, it is still necessary to evaluate it in patients without any endocrinopathies. This meta-analysis aimed to estimate the effectiveness of oral metformin as a monotherapy in acne patients without PCOS or other endocrinopathies. Study selection was performed with included criteria such as no PCOS and other endocrinopathies diagnosed, oral administration of metformin, and metformin in monotherapy. Selected studies contained comparisons in the Global Acne Grading System (GAGS) before and after metformin therapy. Statistical analysis detected significant improvement in skin condition after treatment with metformin.

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“…How Being Obese Affects Acne Vulgaris The development of disease Increased sebum production and the onset of severe acne may be associated with obesity, peripheral hyperandrogenism, insulin resistance, and adipose tissue, the location of androgen biosynthesis. When calculating the prevalence of overweight and obesity, body mass index is a popular statistical tool [27].…”

Section: Clinical Variants Of Acne Vulgarismentioning

confidence: 99%

Pathogenesis of Acne Vulgaris in Adolescence

M. Hamed,

Y. Habashy,

A. El Abd

et al. 2024

Benha Journal of Applied Sciences

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Objectives: Describe the pathophysiology of acne vulgaris and talk about how androgens contribute to the onset of the condition throughout puberty. Background: Acne is a skin ailment that often affects children and teenagers. It seems that the condition is triggered by an increase in the amounts of circulating androgens that originate from the adrenal glands and the testes. Research Methods: We scoured the Medline databases (Pub Med and Medscape) for research that elucidate the pathophysiology of acne vulgaris and address the part played by androgens in the onset of the condition in adolescents up to the year 2023. Research Prioritization: The inclusion of all research was determined by separate evaluations. Inclusion was contingent upon them meeting the following requirements: 1. Presented in an English language format. 2. Publicated in publications that undergo a rigorous peer review process. 3. Explain the process by which acne vulgaris develops and talk about how androgens play a part in this adolescent skin condition. Data Extraction: Studies were omitted from consideration if they failed to meet the inclusion criteria. The study's quality was evaluated based on a number of aspects, such as the following: the availability of sufficient information; the clarity of evaluation criteria; and the acquisition of ethical permission. For our concerned research outcomes, data were independently extracted from all qualifying studies utilizing a data collecting form. Conclusions: Acne is a problem that mostly affects children and teenagers, and it seems that the illness is triggered by elevated amounts of circulating androgens that originate from the adrenal glands and the testicles. Acne pathogenesis involves a series of events that occur in a relatively consecutive order: retained hyperkeratosis, hyperplasia of the sebaceous glands and increased sebum production, follicle colonization by Propionibacterium acnes, and inflammation around the follicles.

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Elevated homeostatic model assessment of insulin resistance level increases the risk of acne

Cited by 3 publications

References 0 publications

Insulin Resistance in Patients with Acne Vulgaris

Insulin Resistance in Patients with Acne Vulgaris

Metformin Therapy for Acne Vulgaris: A Meta-Analysis

Pathogenesis of Acne Vulgaris in Adolescence

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