Elevated insulin resistance in patients with recurrent aphthous stomatitis

Takçı, Zennure; Karadağ, Ayşe Serap; Ertuğrul, Derun Taner; Bilgili, Serap Güneş

doi:10.1007/s00784-014-1339-6

Cited by 14 publications

(12 citation statements)

References 26 publications

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“…Further in this context, the recently reported observation by Takci et al of insulin resistance among patients with aphthous ulcers, especially when in the active stage, adds to the safety margin of our treatment. 19 Lastly, our methodology and results in this regard agree with other studies that utilized topical insulin twice daily for treatment of large area skin wounds for extended periods of time and did not report any side-effects during the study period. 7,10 To our knowledge, this work is the first controlled study using insulin topically on human oral mucosa for management of RAU.…”

Section: Discussionsupporting

confidence: 88%

“…Considering the small surface area of RAU (<10 mm in diameter), its limited duration, the once daily application and the small quantities of the medications used, we think that topical insulin is a safe agent for treatment of RAU in systemically healthy patients. Further in this context, the recently reported observation by Takci et al of insulin resistance among patients with aphthous ulcers, especially when in the active stage, adds to the safety margin of our treatment . Lastly, our methodology and results in this regard agree with other studies that utilized topical insulin twice daily for treatment of large area skin wounds for extended periods of time and did not report any side‐effects during the study period …”

Section: Discussionsupporting

confidence: 88%

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Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

El-Wakeel

Dawoud

2019

J of Invest & Clin Dent

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Aim To evaluate the effectiveness of topical insulin‐liposomal gel in aphthous ulcer treatment. Methods 80 participants with minor aphthous ulcers were randomly divided to receive either topical insulin‐liposomal gel or placebo gel (once daily) for 6 days. Assessment of outcomes included visual analog scale (VAS) for pain (primary outcome), and secondary outcomes included ulcer duration and impact of treatment on quality of life using the Oral Health Impact Profile 14 (OHIP‐14). Testing of the outcomes was carried out at 1, 2, 3, 4 and 6 days after treatment for VAS and at 6 days for OHIP‐14. Results For pain scores, the test group showed a significant decrease by time, this was evident from day 1 (P < .001); at day 3, median and interquartile range (IQR) values were 0 (0‐1). For the placebo group, a non‐significant change by time was reported between baseline and day 1; at day 3, the median value was 7 (IQR, 7‐9). The test group showed significantly lower mean duration than the placebo group (P < .001). OHIP‐14 scores after 6 days showed that the test group had a significantly lower score than placebo (P < .001). Conclusions Topical insulin‐liposomal formulation showed marked effectiveness in management of aphthous ulcers.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

El-Wakeel

Dawoud

2019

J of Invest & Clin Dent

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“…A, E and C in serum and saliva of patients with RAS were signi cantly decreased, and the level of malondialdehyde (MDA) was signi cantly increased, which indicated that the non-enzymatic antioxidant capacity of patients with RAS was impaired [30]. Z. Takci et al showed that insulin resistance (IR) increased in patients with RAS, and IR was more prominent when the patients were in active stage [31]. Extracellular miR-20b-5p derived from exosome is a circulating biomarker associated with type 2 diabetes mellitus, which regulates insulin-stimulated glucose metabolism through AKT signal transduction.…”

Section: Discussionmentioning

confidence: 99%

Identification and Functional Analysis of Serum Specific MiRNAs in Recurrent Aphthous Somatitis Patients With Excess-heat or Yin-deficiency

Bao

Zhu

Zhang

et al. 2020

Preprint

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Background:To identity key miRNAs as signatures for recurrent aphthous stomatitis(RAS)with Excess-heat or Yin-deficiency bymiRNA microarrays. Method: Serum samples were collected from patients meeting the RAS diagnostic criteria of excess-heat oryin-deficiencysyndrome and healthy individuals. CoremicroRNAs (miRNAs) were then identified under miRNA microarray analyses. Target prediction and bioinformatic analyses were carried out andgene-pathway-networks werevisualized to better understand the relationship between differentgenes and pathways.Result:(1) 90 individuals meeting the inclusion criteria were collected in this study, of which 30 were normal control, 30 were patients of excess-heat syndrome and the rest were patients ofyin-deficiency syndrome. Among them, 9 miRNAs werescreened out in excess-heat syndrome group, with 1 upregulated and 8 downregulated. And four randommiRNAs(hsa-miR-20b-5p, hsa-miR-122-5p, hsa-miR-483-5p and hsa-miR-3197) were validatedby real-time PCR method. 14 miRNAs werescreened out in yin-deficiency syndrome group(7 upregulated and 7 downregulated). And hsa-miR-17-5p, hsa-miR-106-5p and hsa-miR-20b-5p were validated. (2)A total of 4776 target genes were identified for the validated 9 miRNAs in excess-heat syndrome group.These targets were enriched inGO categories including nervous system development, homophilic cell adhesion via plasma membrane adhesion molecules, and calcium ion binding and KEGG pathway such as proteoglycans in cancer, P13K-AKT signaling pathway and Calcium signaling pathway. 10172 target genes were identified for the validated 14 miRNAs in yin-deficiency syndrome group. The enrichedGO categories included protein binding, positive regulation of transcription from RNA polymerase II promoter and membrane andenrichedKEGG pathway included pathways in cancer, MAPK signaling pathway and Ras signaling pathway.Conclusion:Hsa-miR-20b-5p in patients with RAS could act as the novel target for syndromeclassification of the disease. It is upregulated in RAS patients with excess-heat syndrome while downregulated in patients with yin-deficiency syndrome. The PI3K-Akt signaling pathway and MAPK signaling pathway and related target genes may provide new insights into the molecular mechanisms of RAS with excess-heat syndrome or yin-deficiency syndrome, respectively.

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“…Many studies have investigated the role of oxidative stress in the etiopathogenesis of RAS, and despite some conflicting data, it seems that oxidative stress is significantly increased in patients with RAS (Tugrul et al, 2015). In a study by Takci et al (Takci et al, 2015) insulin resistance, the major characteristic of metabolic syndrome was found to be significantly higher in patients with RAS than in healthy controls. This is an interesting result because peripheral insulin resistance was explained as an outcome of endothelial dysfunction in Behc ßet's disease (Erdem et al, 2006).…”

Section: Oral Diseasesmentioning

confidence: 99%

Subclinical atherosclerosis in patients with recurrent aphthous stomatitis

Şereflican

Dağıstan

et al. 2016

Oral Diseases

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Elevated insulin resistance in patients with recurrent aphthous stomatitis

Abstract: Patients who admitted the hospital with RAS might be screened for prediabetes.

Cited by 14 publications

References 26 publications

Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

Identification and Functional Analysis of Serum Specific MiRNAs in Recurrent Aphthous Somatitis Patients With Excess-heat or Yin-deficiency

Subclinical atherosclerosis in patients with recurrent aphthous stomatitis

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