Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus

Oweis, Ashraf O; Al‐Qarqaz, Firas; Bodoor, Khaldon; Heis, Leen; Alfaqih, Mahmoud A.; Almomani, Rowida; Obeidat, Motaz; Alshelleh, Sameeha A

doi:10.1016/j.cyto.2020.155369

Cited by 43 publications

(47 citation statements)

References 12 publications

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“…In patients receiving hemodialysis, individuals with uremic pruritus have significantly increased serum levels of IL-31 compared with the levels in those without pruritus [ 68 ]. Oweis et al measured serum levels of IL-31, IL-13 and IL-33 in hemodialysis patients and healthy controls [ 69 ]. The serum level of IL-31, but not those of IL-13 and IL-33, was found to be significantly elevated in hemodialysis patients compared with that in healthy controls.…”

Section: Il-31 In Skin Diseases With Pruritusmentioning

confidence: 99%

“…The serum level of IL-31, but not those of IL-13 and IL-33, was found to be significantly elevated in hemodialysis patients compared with that in healthy controls. However, the serum level of IL-13, but not those of IL-31 and IL-33, was revealed to be significantly correlated with itch intensity [ 69 ]. Serum and cutaneous levels of IL-31 are also elevated in cutaneous T-cell lymphoma [ 19 , 70 , 71 , 72 , 73 ] and are described as being correlated with itch intensity in some reports [ 19 , 73 ].…”

Section: Il-31 In Skin Diseases With Pruritusmentioning

confidence: 99%

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Interleukin-31 and Pruritic Skin

Furue

Furue²

2021

JCM

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Skin inflammation often evokes pruritus, which is the major subjective symptom in many inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is a specific sensation found only in the skin. Recent studies have stressed the pivotal role played by interleukin-31 (IL-31) in the sensation of pruritus. IL-31 is produced by various cells including T helper 2 cells, macrophages, dendritic cells and eosinophils. IL-31 signals via a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor β. Recent clinical trials have shown that the anti-IL-31RA antibody nemolizumab can successfully decrease pruritus in patients with atopic dermatitis and prurigo nodularis. The IL-31 pathway and pruritic skin are highlighted in this review article.

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Section: Il-31 In Skin Diseases With Pruritusmentioning

confidence: 99%

Section: Il-31 In Skin Diseases With Pruritusmentioning

confidence: 99%

Interleukin-31 and Pruritic Skin

Furue

Furue²

2021

JCM

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“…IL-31 is produced mainly by Th 2 lymphocytes and mature DCs [ 171 ] and exerts its biological effects through Janus-kinase (JAK1/JAK2) and other pathways (reviewed in details by Furue et al [ 172 ]). The association between elevated IL-31 and CKD-aI has already been reported by several investigators [ 173 , 174 ], although the blockade of this pathway by nemolizumab (an anti-IL-31 monoclonal antibody) has not provided particularly effective outcomes in a recent phase II study ( n = 69) [ 175 ]. Nevertheless, it seems that overexpressed IL-31 may contribute to CKD-aI through the activation of peripheral sensory nerves [ 174 ], as the expression of IL-31Rα was documented in a subpopulation of TRPV1+/TRPA1+ neurons of dorsal root ganglia in mice [ 171 ].…”

Section: Pathogenesis Of Ckd-aimentioning

confidence: 98%

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Reszke

Kiliś‐Pstrusińska

Szepietowski

2021

Toxins

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Chronic kidney disease (CKD) is a condition of widespread epidemiology and serious consequences affecting all organs of the organism and associated with significant mortality. The knowledge on CKD is rapidly evolving, especially concerning adults. Recently, more data is also appearing regarding CKD in children. Chronic itch (CI) is a common symptom appearing due to various underlying dermatological and systemic conditions. CI may also appear in association with CKD and is termed chronic kidney disease-associated itch (CKD-aI). CKD-aI is relatively well-described in the literature concerning adults, yet it also affects children. Unfortunately, the data on paediatric CKD-aI is particularly scarce. This narrative review aims to describe various aspects of CKD-aI with an emphasis on children, based on the available data in this population and the data extrapolated from adults. Its pathogenesis is described in details, focusing on the growing role of uraemic toxins (UTs), as well as immune dysfunction, altered opioid transmission, infectious agents, xerosis, neuropathy and dialysis-associated aspects. Moreover, epidemiological and clinical aspects are reviewed based on the few data on CKD-aI in children, whereas treatment recommendations are proposed as well, based on the literature on CKD-aI in adults and own experience in managing CI in children.

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“…The potential role of dupilumab in the signaling of IL-4 and/or IL-13 on sensory neurons in the management of uremic pruritus has been demonstrated [197]. IL-31 may also be a future therapeutic target, because increased serum IL-31 levels have been observed in patients with uremic pruritus [198]. Similarly, the pathophysiology of cholestatic pruritus is also multifactorial, and bile acid, lysophosphatidic acid, and bilirubin are potentially important mediators of cholestatic itch.…”

Section: Treatment Strategy For Ad Patients With Concomitant Chronic Renal Insufficiency or Chronic Cholestatic Diseasesmentioning

confidence: 99%

The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

Wong

Yen

Lee

2021

IJMS

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Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.

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Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus

Cited by 43 publications

References 12 publications

Interleukin-31 and Pruritic Skin

Interleukin-31 and Pruritic Skin

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

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