Elevated lactate dehydrogenase is an adverse predictor of outcome in HLA-matched sibling bone marrow transplant for acute myelogenous leukemia

Kalaycio, Matt; Rybicki, Lisa; Pohlman, Brad; Dean, Robert M.; Sweetenham, John W.; Andrèsen, Steven; Sobecks, Ronald; Sekeres, Mikkael A.; Advani, Anjali S.; Brown, Stacey; Bolwell, Brian J.

doi:10.1038/sj.bmt.1705811

Cited by 14 publications

(7 citation statements)

References 34 publications

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“…High lactate dehydrogenase activity was correlated with chemotherapy resistance, less sensitivity to drug, hence short overall survival period and shorter disease free survival period as compared to low lactate dehydrogenase activity group [25].…”

Section: Discussionmentioning

confidence: 90%

Lactate Dehydrogenase (LDH) as Prognostic Marker in Acute Leukemia Quantitative Method

Elbossaty¹

2017

J Blood Disord Transfus

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Lactate dehydrogenase enzyme was found in animal and human and play important role in gluconeogenesis process. It distributed in all organs, but the mainly distributed in liver. To evaluated the level of lactate dehydrogenase (LDH) in acute leukemia and investigated its clinical significance with other hematological and clinical parameters. Serum lactate dehydrogenase (LDH) level was investigated in 50 patients with acute leukemia, 17 patients with acute lymphoblastic leukemia and 33 patients with acute myeloid leukemia, in addition to 20 healthy control cases. The relationship between lactate dehydrogenase level and blood cells were analyzed. LDH level was significant elevated in acute leukemia cases as compared to control group, also LDH level was statistically significant increase in acute lymphoblastic leukemia than in acute myeloid leukemia (p<0.001). There were positively correlation between LDH and white blood cells, bone marrow blasts and uric acid; on the other hand, there were negatively correlation between LDH and red blood cells, and platelets. Lactate dehydrogenases represented as supplementary enzymatic tool can be used as differentiation marker between the different types of leukemia not only but also, follow up the patients during treatment period.

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Section: Discussionmentioning

confidence: 90%

Lactate Dehydrogenase (LDH) as Prognostic Marker in Acute Leukemia Quantitative Method

Elbossaty¹

2017

J Blood Disord Transfus

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“…This registry study proved a significant correlation of serum LDH levels with OS, RFS and CRR in patients with metastasized seminoma. Elevated LDH levels were already associated with poorer outcomes including several solid tumor and hematologic malignancies [18][19][20][21][22] but the value of LDH as a prognostic marker for seminoma patients remained unclear. To find new categories that significantly correlate with outcome, our analysis investigates LDH levels and other patient characteristics as potential prognostic markers, hypothesizing that LDH inversely correlates with outcome in seminoma patients as well.…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)

et al. 2021

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Purpose The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and other clinical characteristics in this subset of patients. Methods Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survival (RFS), overall survival (OS), and complete response rate (CRR). Results The dataset included 351 metastatic seminoma patients with a median follow-up of 5.36 years. Five-year RFS, OS and CRR were 82%, 89% and 52%, respectively. Explorative analysis revealed a cut-off LDH level of < 2.5 upper limit of normal (ULN) (n = 228) vs. ≥ 2.5 ULN (n = 123) to be associated with a significant difference concerning OS associated with 5-years OS rates of 93% vs. 83% (p = 0.001) which was confirmed in multivariate analysis (HR 2.87; p = 0.004). Furthermore, the cut-off LDH < 2.5 ULN vs. ≥ 2.5 ULN correlated with RFS and CRR associated with a 5-years RFS rate and CRR of 76% vs. 86% (p = 0.012) and 32% vs. 59% (p ≤ 0.001), respectively. Conclusions LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratification.

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“…GVHD predisposes graft recipients to the development of AIHA. Data have also shown that high LD activity independently predicts poor prognosis following allogenic bone marrow transplant for AML [25]. A few cases of congenital absence of haptoglobin have been described especially among Blacks of West African origin (Nigeria, Cameroon) where there is a prevalence of approximately 30% [20].…”

Section: Discussionmentioning

confidence: 99%

8. Lactate dehydrogenase

Oladipo¹,

Dietzen²

2014

Diagnostic Enzymology

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A 66-year-old Caucasian female presented to the emergency room with a history of vomiting, diarrhea, worsening shortness of breath, and decreased oral intake. She was previously diagnosed with stage IV non-small cell lung carcinoma. She has a 20 pack-year history of cigarette smoking (1/2 a pack per day for 40 years) prior to diagnosis. On examination she had positive rhonchi bilaterally and decreased breath sounds in the right lower lobe. She had a right pleural effusion on chest X-ray. Her initial biochemical and hematology results are: serum chemistry -sodium 138 mmol/L, potassium 6.9 mmol/L, chloride 89 mmol/L, CO 2 15 mmol/L, glucose 8.1 mmol/L, blood urea nitrogen (BUN) 35.3 mmol/L, creatinine 301 μmol/L, phosphate 1.91 mmol/L, total calcium 2.2 mmol/L, albumin 26 g/L, alanine aminotransferase (ALT) 117 IU/L, alkaline phosphatase (ALP) 431 IU/L, lactate dehydrogenase (LD) 4,477 IU/L, total bilirubin 65 μmol/L, white blood cell (WBC) count 21.6 × 10 9 /L, hemoglobin 143 g/L, mean cell volume (MCV) 98.4 fL, platelets 169 × 10 9 /L, lymphocytes 5%, granulocytes 89.7%, monocytes 3.0%, basophils 1.9%, eosinophils 0.4%. DiscussionThis patient was found to have advanced carcinoma of the lungs and was admitted with a diagnosis of acute renal failure and metabolic acidosis secondary to vomiting and diarrhea. She also had pleural effusion for which she had a chest tube placed. Her liver enzymes showed that LD activity was increased to a greater degree compared with ALT and aspartate aminotransferase (AST) activities. The tumor cells were most likely the main source of LD. Some rapidly growing cancer cells depend on anaerobic glycolysis to generate ATP, even in the presence of adequate oxygen (the Warburg effect), thereby producing more lactate via LD [1]. Adenocarcinoma of the lung is strongly associated with cigarette smoking. A very high total LD, which can be as high as 20 times the upper reference limit, has been reported to be associated with poor outcome and a low survival rate [2]. Increased LD in lung carcinoma has been mainly attributed to LD 3 , LD 4 , and LD 5 isoenzymes [3,4]. In this case, LD isoenzymes were not measured. The renal function of this patient was compromised, as indicated by abnormal BUN and creatinine concentrations. In addition, leukocytosis suggests that this patient has an underlying infection. All these processes would result in tissue destruction and contribute to the circulating pool of LD. Patients who have

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Elevated lactate dehydrogenase is an adverse predictor of outcome in HLA-matched sibling bone marrow transplant for acute myelogenous leukemia

Cited by 14 publications

References 34 publications

Lactate Dehydrogenase (LDH) as Prognostic Marker in Acute Leukemia Quantitative Method

Lactate Dehydrogenase (LDH) as Prognostic Marker in Acute Leukemia Quantitative Method

The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)

8. Lactate dehydrogenase

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