2023
DOI: 10.1093/braincomms/fcad112
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Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage

Abstract: Hypertension in midlife contributes to cognitive decline and is a modifiable risk factor for dementia. The relationship between late-life hypertension and dementia is less clear. We have investigated the relationship of blood pressure and hypertensive status during later life (after 65 y) to post-mortem markers of Alzheimer's disease (amyloid-β and tau loads), arteriolosclerosis and cerebral amyloid angiopathy; and to biochemical measures of ante-mortem cerebral oxygenation (the myelin-associated glycoprotein:… Show more

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Cited by 8 publications
(4 citation statements)
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References 85 publications
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“…This study crafts a narrative where PLTs might serve as silent witnesses, responding to vascular alterations, potentially influencing cerebral perfusion, and contributing to the delicate dance of Aβ. As the late-life decline in blood pressure precedes dementia onset, this study suggests that understanding this interplay could hold the key to decoding the complexities of disease progression [120]. Another study narrates a tale of PLT indices and their intricate dance with cognitive and functional status in older hospitalised individuals.…”
Section: Beura Et Al (2023) [109] Pdmentioning
confidence: 83%
“…This study crafts a narrative where PLTs might serve as silent witnesses, responding to vascular alterations, potentially influencing cerebral perfusion, and contributing to the delicate dance of Aβ. As the late-life decline in blood pressure precedes dementia onset, this study suggests that understanding this interplay could hold the key to decoding the complexities of disease progression [120]. Another study narrates a tale of PLT indices and their intricate dance with cognitive and functional status in older hospitalised individuals.…”
Section: Beura Et Al (2023) [109] Pdmentioning
confidence: 83%
“…These findings indicate the need for further exploration into the direct association between hypertension, microglial alterations, and cognitive decline. Our study design, however, could not address the effects of late-life hypertension on the aging brain, which are rather complex [ 71 ], and future work is needed.…”
Section: Discussionmentioning
confidence: 99%
“…An important and informative study from the Bristol group 1 published recently in Brain Communications provides intriguing data on the possible role of hypertension in maintaining brain oxygenation and modulating the accumulation within the central nervous system (CNS) of amyloid-β protein, thought to be a key element in the progression of brain degeneration associated with dementia. It builds upon many important relevant observations pertinent to brain aging, originating from Professor Love’s group, over several decades.…”
mentioning
confidence: 99%
“…In the time frame during which the subjects were examined clinically, blood pressure assessments probably evolved from manual to more accurate digital measurements. Per Table 1 in their article, 1 the blood pressure measurements may have been as few as four over several years, at least in the Alzheimer’s disease and vascular dementia patient groups. Because the study specimens were obtained from a ‘brain bank’ resource, there is no indication that complete autopsies were frequently, or ever, performed on the subjects, so data on generally accepted classic autopsy evidence of hypertension (nephrosclerosis, cardiac/left ventricular hypertrophy) is not available to provide supporting evidence of longstanding high blood pressure.…”
mentioning
confidence: 99%