Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients

Hintzen, R.Q.; Lier, R. A. W. Van; Kuijpers, K. C.; Baars, Paul A.; Schaasberg, W.; Lucas, C.J.; Polman, Chris H.

doi:10.1016/0165-5728(91)90175-7

Cited by 90 publications

(86 citation statements)

References 35 publications

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“…It has been previously reported that CD27 is transiently up-regulated after T-cell activation in vitro, the peak expression level occurring by 24 hours. 19,20 Our results strongly support that CD27 is also up-regulated following in vivo activation, because CD27 high cells exhibit characteristics of recently activated cells: they were hardly detectable in some donors, and their frequency in the same donor was not stable, suggesting that they may disappear with time. Furthermore, the gene expression profile of these CD27 high subpopulations was very close to that of naive cells.…”

Section: Discussionsupporting

confidence: 66%

Cartography of gene expression in CD8 single cells: novel CCR7− subsets suggest differentiation independent of CD45RA expression

Monteiro

Evaristo

Legrand

et al. 2006

Blood

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Understanding the distribution, function, and lineage relationship of CD8 ؉ T-cell subpopulations is of fundamental value for the monitoring of the immune system in several experimental and clinical situations. However, the available data concerning the description of effector and memory CD8 ؉ subsets in humans remain rather fragmentary because different studies favored the usage of distinct and restricted sets of cell surface markers and functional parameters. We associated multiple markers to subdivide CD8 ؉ T cells into 14 different cell types, several of which were not described previously, and evaluated the coexpression of 18 genes simultaneously in individual cells from each subset. Our results show that each subset has a defined pattern of gene expression. Moreover, effector gene expression of CCR7 ؊ cells correlated only with CD27 expression levels and CD27/ CD28 coexpression but not with CD45RA/R0 phenotypes. Our findings thus describe new CD8 ؉ cell subsets, allow the identification of relatively homogeneous CD8 ؉ subpopulations, provide a predictable and precise correlation between particular cell surface markers and CD8 ؉ T-cell functional properties, and identify effector cells present in both CCR7 ؊ CD45RA ؉ and CCR7 ؊ CD45R0 ؉ compartments. The results also indicate that activated cells might modulate the expression of CD45RA/R0 asynchronously rather than CCR7 ؊ CD45RA ؉ cells always issuing from CD45RA ؊ precur-

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Section: Discussionsupporting

confidence: 66%

Cartography of gene expression in CD8 single cells: novel CCR7− subsets suggest differentiation independent of CD45RA expression

Monteiro

Evaristo

Legrand

et al. 2006

Blood

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“…Perhaps, in situations of chronic activation, CD27-induced apoptosis may play an important role in maintaining self-tolerance and keeping in check activated T and B cells, which may contribute to some autoimmune diseases. In the case of multiple sclerosis, where elevated levels of sCD27 have been reported, it is possible that these elevations may inhibit the regulatory or other effects of CD70-expressing T and B cells (15).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, in murine systems, CD27 is constitutively expressed on all thymocytes (14). A soluble form of CD27 (with the extracellular region clipped by a protease) appears in the culture supernatant and can also be detected in the serum of normal individuals (15). CD27 is also highly expressed in most of the B cell non-Hodgkin lymphomas and B cell chronic lymphocytic leukemias (16,17).…”

mentioning

confidence: 99%

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein

Prasad

Yoon³

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

271

265

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Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of both TNFR1 and Fas can result in programmed cell death or apoptosis. The underlying mechanism requires an intact 80-aa stretch present in the cytoplasmic tails of both TNFR1 and Fas, termed the death domain (DD). Here we show that CD27, a member of the TNFR family, expressed on discrete subpopulations of T and B cells and known to provide costimulatory signals for T and B cell proliferation and B cell Ig production, can also induce apoptosis. Co-crosslinking of surface Ig receptors along with ligation of CD27 augments CD27-mediated apoptosis. Unlike TNFR1 and Fas, the cytoplasmic tail of CD27 is relatively short and lacks the DD. Using the yeast two-hybrid system, we have cloned a novel protein (Siva) that binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway.

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“…Resting and naive B cells usually do not express CD27; however, CD27 expression can be induced by activation of B cells, resulting in sustained expression over long periods of time (20,21). Some low levels of sCD27 are detectable in the serum of healthy individuals, but sCD27 is highly up-regulated in many disease situations including human autoimmune diseases (18).…”

mentioning

confidence: 99%

“…CD27 is constitutively expressed on resting T cells, which can be further up-regulated upon T cell activation, particularly in CD45RA ϩ T cells (14 -17). Activation of T cells can also lead to shedding of CD27 from the cell surface resulting in a soluble form (sCD27) (18). Expression of CD27 on T cells is tightly correlated with the effector functions of these cells (1).…”

mentioning

confidence: 99%

Blocking of CD27-CD70 Pathway by Anti-CD70 Antibody Ameliorates Joint Disease in Murine Collagen-Induced Arthritis

Oflazoglu

Boursalian

Zeng

et al. 2009

The Journal of Immunology

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Rheumatoid arthritis (RA) is characterized by inflammation and cellular proliferation in the synovial lining of joints that result in cartilage and bone destruction. Although the etiology of RA is unclear, activated lymphocytes and proinflammatory molecules, in particular TNF superfamily members, have been implicated in the disease pathology. A TNF superfamily member, CD70, is found on activated lymphocytes and shown to be important in memory and effector responses of lymphocytes. CD70 is expressed at high levels on chronically activated T cells in patients with autoimmune disorders, including RA. The involvement of CD70 in the progression of RA, however, remains unknown. In this study, we report effects of targeting CD70 on disease pathogenesis by using an anti-mouse CD70 Ab in a murine model of collagen-induced arthritis (CIA). In addition to blocking CD70 binding to its receptor CD27, the anti-CD70 Ab used also engages Fc-dependent effector functions including Ab-dependent cellular cytotoxicity, phagocytosis, and complement fixation. Treatment of mice with anti-CD70 Ab both before the onset or after the established disease in CIA model resulted in marked improvements in disease severity and significant reduction in the production of autoantibodies. Histopathological analyses of the joints of mice revealed a substantial reduction of inflammation, and bone and cartilage destruction in response to the anti-CD70 Ab treatment. These results uncover a novel role for CD27-CD70 interactions in the regulation of in vivo inflammatory response leading to arthritis, and provide a molecular basis to support the rationale for anti-CD70 therapy for autoimmune and inflammatory diseases.

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Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients

Cited by 90 publications

References 35 publications

Cartography of gene expression in CD8 single cells: novel CCR7− subsets suggest differentiation independent of CD45RA expression

Cartography of gene expression in CD8 single cells: novel CCR7− subsets suggest differentiation independent of CD45RA expression

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein

Blocking of CD27-CD70 Pathway by Anti-CD70 Antibody Ameliorates Joint Disease in Murine Collagen-Induced Arthritis

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