Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer

Iino, Koichi; Seppälä, Markku; Heinonen, Pentti K.; Sipponen, P; Rutanen, Eeva‐Marja

doi:10.1002/1097-0142(19861115)58:10<2294::aid-cncr2820581023>3.0.co;2-q

Cited by 22 publications

(10 citation statements)

References 12 publications

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“…19 Raised serum IGFBP-1 values have been reported in patients with primary liver cancer 20 and ovarian cancer. 21 Whether these serum concentrations of IGFBP-1 are related to tumour cachexia or to production by the tumour itself is unclear. In the serum of patients with non-islet cell tumour hypoglycaemia, free IGF-I and IGF-II, in addition to IGFBP-1 and IGFBP-2 values, are raised.…”

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confidence: 99%

IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

Zumkeller

2001

Molecular Pathology

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Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance. (J Clin Pathol: Mol Pathol 2001;54:285-288)

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IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

Zumkeller

2001

Molecular Pathology

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“…The IGFBP-1 was detected in the serum of patients with ovarian carcinomas (Lino et al, 1986) and lung cancer . Furthermore, the IGFBP-2 was found in the supernatant of breast and prostate cancer cells (Adamo et al, 1992;Reeve and Kirby, 1992) and several other human tumour cell lines (Kanety et al, 1993), suggesting IGFBP-2 gene expression by the tumour cells.…”

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confidence: 99%

Elevated serum levels of IGFBP-2 found in children suffering from acute leukaemia is accompanied by the occurrence of IGFBP-2 mRNA in the tumour clone

Wex

Vorwerk²,

Mohnike³

et al. 1998

Br J Cancer

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Summary Insulin-like growth factor-binding proteins (IGFBPs) are important modulators of IGF action. In 50 children suffering from acute lymphoblastic leukaemia (ALL), we studied the serum levels of IGFBP-1,-2 and-3. The mean standard deviation score (SDS) values were estimated to be 0.7, 3.1 and -1.7 for the IGFBP-1,-2 and-3, respectively, compared with the normal range defined by a SDS from -2 to +2. IGFBP-1 and-3 were normal, but for IGFBP-2 we found a significantly elevated serum level compared with control groups (P < 0.05). However, during chemotherapy this increased serum IGFBP-2 normalized. In addition, we found a correlation between higher serum levels and the detection rate of the IGFBP-2 transcript in corresponding cells. In patients with ALL, the detection rates of IGFBP-2 mRNA were estimated to be 72% and 35% at the time of diagnosis and at day 33 of chemotherapy respectively; in the control groups (healthy children and children at their initial presentation of diabetes mellitus), the values were 28% and 33% respectively. Based on the correlation between IGFBP-2 serum levels and the corresponding gene expression as well as the normalization of IGFBP-2 levels during chemotherapy, we concluded that the increased serum level mainly originated from the tumour clone itself. Furthermore, possible functional consequences of elevated IGFBP-2 were outlined.

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“…Interestingly, many types of tumors express high levels of placental protein 12 (34,35). While the biological actions of placental protein 12 are unknown, the IGF-I binding capability and its secretion into amniotic fluid suggests that placental protein 12 may regulate fetal growth (36).…”

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Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.

Simon

Podolsky

Moldenhauer

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

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The cell surface antigen, epithelial glycoprotein, defined by the monoclonal antibody HEA 125, is expressed on virtually all epithelial cell membranes but not on mesodermal or neural cell membranes. The cDNA encoding epithelial glycoprotein was isolated by HEA 125 antibody enrichment ofcolon tumor cDNA expressed transiently in COS cells. The sequence of the epithelial glycoprotein antigen is identical to the cell membrane protein recognized by the monoclonal antibody KS 1/4 and is homologous to the tumor-assoiated antigen GA733.These proteins share sequence homology to nidogen, an extracellular matrix component that appears to participate in cellmatrix adhesion. These proteins also share a homologous domain found in the Bi chain of laminin, a matrix adhesion protein, and placental protein 12, an insuidn-like growth factor I binding protein secreted during pregnancy that has been implicated in regulation of fetal growth. This common domain is also repeated multiple times within the thyroglobulin precursor. These fin gs suggest epithelial glycoprotein is a cell surface molecule involved in cell-cell or cell-matrix interaction.

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Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer

Cited by 22 publications

References 12 publications

IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

Elevated serum levels of IGFBP-2 found in children suffering from acute leukaemia is accompanied by the occurrence of IGFBP-2 mRNA in the tumour clone

Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein.

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