Elevated levels of acute phase plasma proteins in major depression

Screening, Diagnosis, and Treatment of Depression in Patients with End-Stage Renal Disease

“…In previous studies, increased depressive affect was associated with markers of poor compliance in dialysis patients (9,19,20). Depression has also been associated with altered immune system function, specifically decreased cellular immunity, and increased cytokine levels (10,(21)(22)(23)(24). Furthermore, depression is linked to poor nutritional status and has been shown to precede a decline in serum albumin levels in patients with ESRD (25,26).…”

Negative Immunoregulatory Effects of Antidepressants Inhibition of Interferon-γ and Stimulation of Interleukin-10 Secretion

“…The evidence includes the following: (1) increased numbers of peripheral blood mononuclear cells (PBMC), such as neutrophils, monocytes, and activated T lymphocytes (Herbert and Cohen 1993;Maes et al 1992Maes et al , 1993cMuller et al 1993;Sluzewska et al 1996aSluzewska et al , 1996bSeidel et al 1996b;Perini et al 1995); (2) increased secretion of neopterin, a sensitive marker of cell-mediated immunity (Duch et al 1984;Dunbar et al 1992;Maes et al 1994;Bonaccorso et al 1997); (3) increased secretion of prostaglandin E2 (PGE2) in serum, CSF or culture supernatant obtained after polyclonal stimulation of whole blood (Linnoila et al 1983;Calabrese et al 1986;Song et al submitted;and (4) the presence of a moderate acute phase response, as indicated by increased serum concentrations of positive acute phase reactants, such as haptoglobin, C-reactive protein, and ␣ 1-antitrypsin (Maes et al 1993b(Maes et al , 1995b(Maes et al , 1997aJoyce et al 1992;Sluzewska et al 1996a) and decreased serum concentrations of negative acute phase reactants, such as albumin, transferrin, and zinc (Swartz 1990;Maes 1997;McLoughlin and Hodge 1990;Maes et al 1997b). Activation of the IRS has also been observed in the olfactory bulbectomized and the mild stress rat model of depression Sluzewska et al 1994).…”

Serum cortisol, immunoglobulins and some complements among depressed patients

“…The depressed men had significantly elevated levels of the acute phase proteins, haptoglobin and alpha-1-antichymotrypsin, and of immunoglobulin G(23). In one research, no significant difference between the mean levels of C3 could be detected between depressed patients and controls, the levels of C4 (23,24). C-reactive protein was significantly raised in the group with a depressive disorder.…”