Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes

Guo, Qingqu; Kang, Muxing; Zhang, Bo; Chen, Ying; Dong, Xin; Wu, Yulian

doi:10.1007/s00432-010-0820-0

Cited by 29 publications

(17 citation statements)

References 29 publications

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“…Furthermore, the serum levels of the tumor markers are even less useful for the diagnosis of PMC [24,25]. Bassi et al [24] found that CEA again seems to be the most accurate indicator for the diagnosis of a mucinous cyst, but with a sensitivity as low as 17%.…”

Section: Discussionmentioning

confidence: 99%

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Tica

Săftoiu

et al. 2013

Gynecol Obstet Invest

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Pancreatic mucinous cystic neoplasms are uncommon and their occurrence in pregnancy is extremely rare. The authors report the unique case of a newborn weighing 3,620 g, delivered vaginally with no complications by a patient with a large ‘silent' pancreatic mucinous cystic neoplasms, and analyze the very few other reports. With no available protocol, this case highlights an interesting dilemma on the management of pregnancy and delivery as well on the timing of pancreatic surgery. Despite its limitations, MRI remains the most accurate investigation either for differentiating the mucinous from nonmucinous cysts or for evaluating the malignancy, but echography is also very useful. Without symptoms, all low-grade malignant potential tumors, independent of the moment of their diagnosis during pregnancy, should be resected 2-3 months after delivery and we believe that the best option is a term vaginal birth, even in the presence of a large cyst and large fetus. On the contrary, all high-grade malignant potential tumors, discovered in the first two trimesters of pregnancy should be resected during the second trimester, and followed by a vaginal delivery at term. If high-grade malignant potential tumor is diagnosed in the third trimester, an early vaginal delivery followed by surgery is recommended. Finally, the patient's preference is crucial.

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Section: Discussionmentioning

confidence: 99%

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Tica

Săftoiu

et al. 2013

Gynecol Obstet Invest

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“…In selected cases where there is clinical suspicion or risk factor of PaC further evaluation should be made with assessment of tumor markers like CA-19-9 and CEA. Both of these markers have shown a positive correlation with PaC-associated diabetes [9].…”

Section: Discussionmentioning

confidence: 96%

New-onset hyperglycemia: A potential clue to detect early pancreatic cancer

Chakraborty

Ray

Mukhopadhyay

et al. 2017

Clinical Diabetology

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“…Cancer antigen (CA) 19–9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes. Thus, the diagnosis of new-onset diabetes combined with higher CA 19–9 and/or carcinoembryonic antigen (CEA) might be regarded as a useful tool to screen early pancreatic cancer [80]. …”

Section: Reviewmentioning

confidence: 99%

The bidirectional interation between pancreatic cancer and diabetes

Cao

et al. 2012

World J Surg Onc

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The bidirectional interation between pancreatic cancer (PanCa) and diabetes has been confirmed by epidemiological studies, which provide evidence-based medical support for further research into the mechanisms involved in the interaction. We reviewed the literature regarding the role of diabetes in the generation and progression of PanCa and the mechanism by which PanCa induces diabetes for its malignant progression. The effect of antidiabetic drugs on the occurrence and prognosis of PanCa was also reviewed. Diabetes may directly promote the progression of PanCa by pancreatic duct enlargement and hypertension, as well as by enabling an increased tumor volume. Hyperinsulinemia, insulin resistance, cytokines, hyperglycemia and genotype change are also important factors in the progression of PanCa with diabetes. Hyperglycemia may be the first clinical manifestation and is helpful in the early diagnosis of PanCa. Furthermore, antidiabetic drugs can have different effects on the occurrence and prognosis of PanCa. The bidirectional interation between PanCa and diabetes is involved in the occurrence, proliferation, invasion, metastasis and prognosis of PanCa with diabetes. The discovery of biomarkers for the early diagnosis of PanCa, as well as the novel usage of metformin for its antitumor effects and determining the potential mechanisms of these effects, may be the next direction for PanCa research and treatment.

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Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes

Abstract: Elevated CEA (≥5 ng/ml) and CA19-9 (≥500 U/ml) levels have an association with diabetic pancreatic cancer. New-onset diabetes combined with higher CA 19-9 and/or CEA might be regarded as a useful tool to screen early pancreatic cancer.

Cited by 29 publications

References 29 publications

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

Large Pancreatic Mucinous Cystic Neoplasm during Pregnancy: What Should Be Done?

New-onset hyperglycemia: A potential clue to detect early pancreatic cancer

The bidirectional interation between pancreatic cancer and diabetes

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