Elevated levels of D‐dimer tested by immunoturbidimetry are associated with the extent of severity of pre‐eclampsia

Rodríguez-Peña, Yolima; Ibáñez-Pinilla, Milcíades

doi:10.1002/ijgo.13163

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…Further, in the second trimester of pregnancy, D-dimers were positively correlated with fibrinogen (r = 0.475; p 0.001). Rodríguez-Peña and Ibáñez-Pinilla (17) discovered a correlation between high D-dimer levels and the severity of pre-eclampsia. They also found a link between elevated D-dimer levels and the severity of preeclampsia, lending credence to the idea that the activation of fibrinolysis and the coagulation system is a key physiopathologic component of the disease.…”

Section: Resultsmentioning

confidence: 98%

Study of Plasma D-Dimer Level in Normal Pregnancy and Complicated Pregnancy

Zaitoun¹,

Elbhiedy²,

Jama³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: For further testing to rule out venous thromboembolism (VTE), pregnant women with high D-dimer levels are mandated to undergo further screening. Objective: Early detection of complicated pregnancy through evaluation of D-dimer level. Patients and methods: A total of 175 women were included in this case-control study and divided into 2 main groups: Group A "normal pregnancy": included 75 women who were subdivided into 3 equal groups (25 in each trimester) and group B "complicated pregnancy" that included 100 women all of them were in 3rd trimester of pregnancy who were subdivided into 4 equal groups (mild preeclampsia, severe preeclampsia, gestational diabetes mellitus and preterm rupture of membrane). D-dimer was assessed among all participants. Results: D-dimer (DD) and fibrinogen levels were significantly increased with increasing of gestational age. Fibrinogen and white blood cells levels were statistically significantly higher among diabetic, preterm rupture of membrane (PROM) and patients with mild preeclampsia, while D-dimer, platelet and hemoglobin levels were not significantly different when compared to normal pregnancy cases. D-dimer, fibrinogen and white blood cells in our study were significantly increased in cases of severe preeclampsia when compared to normal ones. So, D-dimer was considered a highly sensitive and specific biomarker in diagnosis of sever preeclampsia as D-dimer >100 ng/ml had 88% accuracy in prediction of sever preeclampsia. Conclusion: D-dimer was a highly sensitive and specific biomarker in diagnosis of severe preeclampsia only. D-dimer >100 ng/ml had 88% accuracy in prediction of sever preeclampsia.

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Section: Resultsmentioning

confidence: 98%

Study of Plasma D-Dimer Level in Normal Pregnancy and Complicated Pregnancy

Zaitoun¹,

Elbhiedy²,

Jama³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…In another study, Chu et al [ 24 ] found that as HDPs worsened, DD, Fib, and vWF: Ag levels increased significantly higher in mild, moderate, and severe patients, as compared with controls. Rodríguez-Peña et al [ 25 ] used an immunoturbidimetric assay to detect DD and found that elevated levels of DD were strongly associated with SPE. This further demonstrated that fibrinolytic activation and the activation of the coagulation system may be involved in the pathogenesis of SPE.…”

Section: Discussionmentioning

confidence: 99%

Predicting Hypertensive Disease in the First Trimester of Pregnancy: Risk Models and Analysis of Serum D-dimer Levels Combined with Plasma Pregnancy-Associated Protein A, Free β-Subunit of Human Chorionic Gonadotropin, and Fetal Nuchal Translucency

Chen

Ning

Chu³

et al. 2022

BioMed Research International

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We aimed to investigate the predictive ability of serum levels of D-dimer (DD) in the first trimester for the occurrence of hypertensive disorders of pregnancy (HDP). In this retrospective, case-cohort study, we measured the levels of DD, plasma pregnancy-associated protein A (PAPP-A), and free β-subunit of human chorionic gonadotropin (free β-hCG) and analyzed fetal nuchal translucency (NT) in 150 healthy gravidas, 126 cases of gestational hypertension (GH), 53 cases of preeclampsia (PE), and 41 cases with severe preeclampsia (SPE). Likelihood ratio models and risk models were built using single markers (DD, PAPP-A, free β-hCG, and NT) and combinations of those markers. Analyses showed that the levels of DD multiple of the median (MoM) in the GH, PE, and SPE groups were all significantly higher than those in the control group, with significant differences between groups ( χ 2 = 70.325 , P < 0.001 ). The area under curve (AUCs) for DD in the GH, PE, and SPE groups was 0.699, 0.784, and 0.893, respectively; the positive likelihood ratio (+LR) was 1.534, 1.804, and 2.941, respectively; and the negative likelihood ratio (-LR) was 0.022, 0.081, and 0, respectively. When the cut-off values of DD for the GH, PE, and SPE groups were 0.725, 0.815, and 0.945 MoM, respectively, the corresponding sensitivities were 0.992, 0.962, and 1.000, respectively. As gestational hypertension progressed, the levels of DD tended to increase gradually. The maternal serum level of DD in the first trimester had correlative and diagnostic value for HDP. The sensitivity and specificity of maternal serum levels of DD level in the first trimester for different types of HDP were significantly different; the best sensitivity and specificity were detected in the SPE group. First trimester DD level, combined with other biochemical markers, may improve our ability to diagnose HDP.

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“…Preeclamptic women are more likely to suffer PPH than low-risk women (10% VS 0.4-1.3%) [ 20 ]. Significantly higher D-dimer plasma levels were found in sPE group than those in mPE group [ 3 , 21 , 22 ], suggesting the more aggressively activated coagulation and fibrinolysis systems in severe preeclampsia [ 17 ], which might lead to more blood loss in sPE women. The D-dimer plasma level increased gradually with the increase of gestational age during normal pregnancy [ 5 , 21 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

The association of antenatal D-dimer and fibrinogen with postpartum hemorrhage and intrauterine growth restriction in preeclampsia

Shao

Gao

Dai

et al. 2021

BMC Pregnancy Childbirth

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Background D-dimer and fibrinogen were verified to be altered in preeclampsia. This study was to evaluate the associations of D-dimer and fibrinogen plasma levels with postpartum hemorrhage or intrauterine growth restriction in preeclamptic women. Methods This was a retrospective study that recruited 278 preeclamptic women with singleton pregnancy from January 2016 to December 2019. Patients were allocated into five groups: mild preeclampsia (mPE) (n=68), mild preeclampsia with postpartum hemorrhage (mPE+PPH) (n=13), severe preeclampsia (sPE) (n=112), severe preeclampsia with postpartum hemorrhage (sPE+PPH) (n=17) and severe preeclampsia with intrauterine growth restriction (sPE+IUGR) (n=68). The antenatal D-dimer and fibrinogen plasma levels were analyzed among the groups. Logistic regression was used to determine the correlation between serum indexes and PPH or IUGR in preeclampsia. Results The antenatal D-dimer plasma levels were significantly higher in the sPE+PPH group than that in the sPE group (2.02 μg/ml versus 1.37 μg/ml, P = 0.001), but there was no difference in fibrinogen. Elevated D-dimer was associated with PPH among severe preeclamptic women (adjusted odds ratio (aOR) [95% CI]: 3.093 [1.527-6.264], P = 0.002). No differences in D-dimer and fibrinogen were found between the mPE and mPE+PPH groups or between the sPE and sPE+IUGR groups. Conclusions Elevated antenatal plasma D-dimer level may be associated with postpartum hemorrhage in severe preeclampsia, but not with intrauterine growth restriction. Future prospective clinical trials are needed to investigate the predictive value of D-dimer in postpartum hemorrhage in severe preeclampsia.

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Elevated levels of D‐dimer tested by immunoturbidimetry are associated with the extent of severity of pre‐eclampsia

Cited by 10 publications

References 24 publications

Study of Plasma D-Dimer Level in Normal Pregnancy and Complicated Pregnancy

Study of Plasma D-Dimer Level in Normal Pregnancy and Complicated Pregnancy

Predicting Hypertensive Disease in the First Trimester of Pregnancy: Risk Models and Analysis of Serum D-dimer Levels Combined with Plasma Pregnancy-Associated Protein A, Free β-Subunit of Human Chorionic Gonadotropin, and Fetal Nuchal Translucency

The association of antenatal D-dimer and fibrinogen with postpartum hemorrhage and intrauterine growth restriction in preeclampsia

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