Elevated levels of IL-24 in systemic lupus erythematosus patients

Li, R C; Guo, Jianping; Su, Lin‐Chong; Huang, An‐Fang

doi:10.1177/0961203319845476

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Previous studies found elevated serum level of IL-19 in patients with diabetic nephropathy [7]. Moreover, positive correlation was demonstrated between serum IL-24 level and the severity of lupus nephritis and renal ischemic/ reperfusion injury [8,17]. Considering the above data strongly implies the role of the IL-20 subfamily in the pathomechanism of different renal diseases.…”

Section: Discussionmentioning

confidence: 64%

“…Recently, connection between IL-20 subfamily of cytokines and CKD has been proposed. Indeed, increased serum level of IL-19 and IL-24 was demonstrated in diabetic nephropathy and lupus nephritis [7,8]. Furthermore, our previous genome-wide analysis performed on new-born rat kidneys suggested the possible role of IL-24 in the renal tissue remodeling, as well [9].…”

Section: Introductionmentioning

confidence: 91%

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Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24

et al. 2020

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Background: Recently, the role of IL-19, IL-20 and IL-24 has been reported in renal disorders. However, still little is known about their biological role. Methods: Localization of IL-20RB was determined in human biopsies and in the kidneys of mice that underwent unilateral ureteral obstruction (UUO). Renal Il19, Il20 and Il24 expression was determined in ischemia/reperfusion, lipopolysaccharide, streptozotocin, or UUO induced animal models of kidney diseases. The effects of H 2 O 2 , LPS, TGF-β1, PDGF-B and IL-1β on IL19, IL20 and IL24 expression was determined in peripheral blood mononuclear cells (PBMCs). The extents of extracellular matrix (ECM) and α-SMA, Tgfb1, Pdgfb, and Ctgf expression were determined in the kidneys of Il20rb knockout (KO) and wild type (WT) mice following UUO. The effect of IL-24 was also examined on HK-2 tubular epithelial cells and NRK49F renal fibroblasts. Results: IL-20RB was present in the renal biopsies of patients with lupus nephritis, IgA and diabetic nephropathy. Amount of IL-20RB increased in the kidneys of mice underwent UUO. The expression of Il19, Il20 and Il24 increased in the animal models of various kidney diseases. IL-1β, H 2 O 2 and LPS induced the IL19, IL20 and IL24 expression of PBMCs. The extent of ECM, α-SMA, fibronectin, Tgfb1, Pdgfb, and Ctgf expression was lower in the kidney of Il20rb KO compared to WT mice following UUO. IL-24 treatment induced the apoptosis and TGF-β1, PDGF-B, CTGF expression of HK-2 cells. Conclusions: Our data confirmed the significance of IL-19, IL-20 and IL-24 in the pathomechanism of renal diseases. Furthermore, we were the first to demonstrate the pro-fibrotic effect of IL-24.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 91%

Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24

et al. 2020

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“…A previous study 164 showed that IL‐19 level was slightly increased in SLE patients compared with healthy individuals. Another study 165 also found that IL‐24 level was significantly elevated and correlated with disease activity in SLE patients. However, there was another report showed that no difference was found in serum IL‐24 levels between SLE patients and healthy individuals 164,166 .…”

Section: Introductionmentioning

confidence: 85%

Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?

Hsing

Chiu

et al. 2021

IUBMB Life

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology that can affect nearly every organ system in the body. Besides genetic and environmental factors, unbalanced pro‐inflammatory and anti‐inflammatory cytokines contribute to immune dysregulation, trigger an inflammatory response, and induce tissue and organ damage. Inflammatory responses in SLE can be promoted and/or maintained by the availability of cytokines that are overproduced systemically and/or in local tissues. Several key cytokines have been considered potential targets for the reduction of chronic inflammation in SLE. Recent studies indicated that dysregulated production of several cytokines, including those of the IL‐1 family and IL‐10 family, orchestrate immune activation and self‐tolerance, play critical roles in the pathogenesis of SLE. Among IL‐1 family cytokines, IL‐1, IL‐18, IL‐33, IL‐36, IL‐37, and IL‐38 had been the most thoroughly investigated in SLE. Additionally, IL‐10 family cytokines, IL‐10, IL‐20, IL‐22, IL‐26, IL‐28, and IL‐29 are dysregulated in SLE. Therefore, a better understanding of the initiation and progression of SLE may provide suitable novel targets for therapeutic intervention. In this review, we discuss the involvement of inflammation in the pathogenesis of SLE, with a focus on IL‐1 family and IL‐10 family cytokines, and highlight pathophysiological approaches and therapeutic potential for treating SLE.

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“…It is characterized by the production of autoantibodies—including anti-nuclear (ANAs), anti-double-stranded DNA (dsDNA), anti-Smith antigen (Sm), and anti-ribonucleoproteins (RNP)—against the self-antigen from cell nuclei. IL-24 serum levels are significantly higher in patients with SLE compared with healthy individuals, and elevated IL-24 levels are also associated with disease severity [ 53 ]. However, no significant difference in IL-24 serum levels was observed between SLE patients and healthy controls in two other independent studies [ 39 , 54 ].…”

Section: Il-24 In Inflammatory and Autoimmune Diseasesmentioning

confidence: 99%

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

Zhong

Zhang

Chong

2022

IJMS

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Interleukin (IL)-24 belongs to the IL-10 family and signals through two receptor complexes, i.e., IL-20RA/IL-20RB and IL-20RB/IL22RA1. It is a multifunctional cytokine that can regulate immune response, tissue homeostasis, host defense, and oncogenesis. Elevation of IL-24 is associated with chronic inflammation and autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). Its pathogenicity has been confirmed by inducing inflammation and immune cell infiltration for tissue damage. However, recent studies also revealed their suppressive functions in regulating immune cells, including T cells, B cells, natural killer (NK) cells, and macrophages. The tolerogenic properties of IL-24 were reported in various animal models of autoimmune diseases, suggesting the complex functions of IL-24 in regulating autoimmunity. In this review, we discuss the immunoregulatory functions of IL-24 and its roles in autoimmune diseases.

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Elevated levels of IL-24 in systemic lupus erythematosus patients

Cited by 7 publications

References 31 publications

Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24

Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24

Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?

Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases

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