Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes

Wegeberg, Anne-Marie; Okdahl, Tina; Riahi, Sam; Ejskjær, Niels; Pociot, Flemming; Størling, Joachim; Brock, Birgitte; Brock, Christina

doi:10.1186/s12933-021-01437-w

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…have shown that elevated levels of interleukin-12 may serve as a potential indicator of dysfunctional heart rate variability in diabetic patients. [ 31 ] Our study shows significant arrhythmia and ECG changes in this population and is essential for primary care and emergency physicians dealing with COVID-19 to be prepared to arrhythmic cardiac emergencies in this subset of patients. Further studies with IL-6 levels and cardiac imaging need to be done to look for structural effects and also studies to look at whether anticytokine therapies can reverse these adverse effects.…”

Section: Discussionmentioning

confidence: 93%

Electrocardiographic abnormalities in patients with COVID-19 pneumonia and raised interleukin-6

Walia

Kaeley

Mahala

et al. 2022

Journal of Family Medicine and Primary Care

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Background: Cardiac injury is associated with high mortality in patients with COVID-19 infection. Electrocardiographic changes can give clues to the underlying cardiovascular abnormalities. Raised inflammatory markers like raised interleukin-6 (IL-6) are associated with arrhythmia, heart failure, and coronary artery disease. However, past studies have not highlighted the electrocardiographic abnormalities in patients with COVID-19 infection with raised IL- 6 levels. This study compared the electrocardiogram (ECG) changes in COVID-19 patients with high and normal IL-6 levels. Methods: A retrospective analysis of ECG of 306 patients with COVID-19 infection was done, out of which 250 patients had normal IL- 6 levels, whereas 56 patients had raised IL-6 levels. IL-6 levels were measured in all the patients. Detailed clinicodemographic profile of all the serial COVID-19 patients admitted with moderate to severe COVID-19 pneumonia was noted from the hospital record section. Electrocardiographic findings and biochemical parameters of all the patients were noted. Results: Out of 56 patients with raised IL-6 levels, 41 (73.2%) patients had ECG abnormalities compared to 177 (70.8%) patients with normal IL-6 levels. This difference was not statistically significant. However, ECG abnormality such as sinus tachycardia was significantly more common in patients with raised IL-6 levels than those with normal levels. Among patients with raised IL-6 levels who were discharged, 5 (16.6%) had sinus tachycardia, 2 (6.6%) had ST/T wave changes as compared to 15 (57.6%), and 10 (38.4%) who had tachycardia and ST/T wave change respectably succumbed to death. This difference was statistically significant. Conclusions: Sinus tachycardia followed by atrial fibrillation and right bundle branch block are common ECG changes in patients with COVID-19 infection with raised IL-6. The possible association of cardiac injury in patients with COVID-19 infection with coexisting raised IL-6 levels should be explored further.

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Section: Discussionmentioning

confidence: 93%

Electrocardiographic abnormalities in patients with COVID-19 pneumonia and raised interleukin-6

Walia

Kaeley

Mahala

et al. 2022

Journal of Family Medicine and Primary Care

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“…Initial findings showed a significant negative correlation between ICAM‐1 and SDANN (Standard deviation of the average NN intervals), rMSSD (Root mean square of successive RR interval differences), VLF (Very low frequency), or LF (Low frequency), demonstrating a correlation between decreased parasympathetic and sympathetic activity and elevated ICAM‐1 levels. Crucially, the statistical significance of the link between SDANN and the variable of interest remained even after controlling for demographics, diabetes‐related variables, and cardiovascular risk factor 69 …”

Section: Icam‐1 and Cvdmentioning

confidence: 95%

“…Crucially, the statistical significance of the link between SDANN and the variable of interest remained even after controlling for demographics, diabetes-related variables, and cardiovascular risk factor. 69 In another study, Herder et al studied the relationship between ICAM-1 and HRV measures in T2DM patients. The initial data revealed a substantial negative connection between ICAM-1 and SDANN, rMSSD, VLF, and LF, implying that increased ICAM-1 levels were associated with lower parasympathetic and sympathetic activity.…”

Section: Metabolic Abnormalities and Icam-1mentioning

confidence: 99%

Unveiling the crucial role of intercellular adhesion molecule‐1 in secondary diabetic complications

Kaur,

Dahiya,

Nandave

et al. 2024

Cell Biochemistry & Function

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Diabetes mellitus is associated with secondary complications such as diabetic retinopathy (DR), nephropathy (DN), and cardiomyopathy (DCM), all of which significantly impact patient health. Intercellular adhesion molecule‐1 (ICAM‐1) has been implicated in inflammatory responses and endothelial dysfunction, both crucial in the pathogenesis of these complications. The goal of this review is to investigate at potential therapy methods that target ICAM‐1 pathways and to better understand the multifaceted role of ICAM‐1 in secondary diabetic problems. A meticulous analysis of scholarly literature published globally was conducted to examine ICAM‐1involvement in inflammatory processes, endothelial dysfunction, and oxidative stress related to diabetes and its complications. Elevated ICAM‐1 levels are strongly associated with augmented leukocyte adhesion, compromised microvascular function, and heightened oxidative stress in diabetes. These pathways contribute significantly to DR, DN, and DCM pathogenesis, highlighting ICAM‐1 as a key player in their progression. Understanding ICAM‐1 role in secondary diabetic complications offers insights into novel therapeutic strategies. Targeting ICAM‐1 pathways may mitigate inflammation, improve endothelial function, and ultimately attenuate diabetic complications, thereby enhancing patient health outcomes. Continued research in this area is crucial for developing effective targeted therapies.

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“…Moreover, systemic low-grade inflammation is associated with objective measures of commonly diagnosed complications such as distal symmetrical polyneuropathy and diabetic autonomic neuropathy [ 9 , 10 ]. Consequently, circulating biomarkers may reflect local neuroinflammation in diabetes [ 11 , 12 , 13 ], and it is plausible that systemic inflammation also impairs the enteric nervous system, thereby deteriorating motility in diabetes, causing gastroenteropathy.…”

Section: Introductionmentioning

confidence: 99%

Systemic Cytokine Expression in Diabetes Is Associated with Prolonged Gastrointestinal Transit Times and Cardinal Gastroparesis Symptoms

et al. 2023

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Gastroenteropathy is a common complication in diabetes associated with damages to the enteric nervous system. Systemic low-grade inflammation facilitates neurotoxicity, and associations with peripheral and autonomic neuropathy have been reported. However, less is known of associations with gastroenteropathy. To explore the area cross-sectionally, we included individuals with diabetes (type 1: 56, type 2: 100) and 21 healthy controls. Serum levels of interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor (TNF)-α, and interferon (IFN)-γ were measured by multiplex technology. Segmental gastrointestinal transit times were assessed by wireless motility capsule investigations. Symptoms of gastroparesis were rated on Gastroparesis Cardinal Symptom Index questionnaires. Compared to healthy, levels of TNF-α were decreased in type 1 diabetes and increased in type 2 diabetes, while colonic transit time was increased (all p < 0.05). In diabetes, associations between IL-8 and prolonged gastric emptying (odds ratio (OR) 1.07, p = 0.027) and between IL-10 and prolonged colonic transit (OR 29.99, p = 0.013) were seen. Inverse correlations between IL-6 and nausea/vomiting (rho = −0.19, p = 0.026) and bloating (rho = −0.29; p < 0.001) were found. These findings indicate a plausible interaction between inflammation and the enteric nervous system in diabetes, which raises the question of whether anti-inflammatory strategies could be applied in management of diabetic gastroenteropathy.

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Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes

Cited by 10 publications

References 41 publications

Electrocardiographic abnormalities in patients with COVID-19 pneumonia and raised interleukin-6

Electrocardiographic abnormalities in patients with COVID-19 pneumonia and raised interleukin-6

Unveiling the crucial role of intercellular adhesion molecule‐1 in secondary diabetic complications

Systemic Cytokine Expression in Diabetes Is Associated with Prolonged Gastrointestinal Transit Times and Cardinal Gastroparesis Symptoms

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