Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso

Chillemi, Rosa; Simporé, Jacques; Persichilli, Silvia; Minucci, Angelo; D'Agata, Antonio; Musumeci, Salvatore

doi:10.1515/cclm.2005.131

Cited by 16 publications

(12 citation statements)

References 32 publications

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“…Genotypic frequencies for this gene (78.6% AA, 19% AC, and 2.4% CC) in our study are also similar to those found in 20–45 years of age (79.27% AA, 17.07% AC, and 3.66% CC) in Burkina Faso [7]. …”

Section: Discussionsupporting

confidence: 88%

“…The genotypic frequencies found for the MTHFR C677T mutation are similar to those already reported in Burkina Faso [7]. Our results, however, differ from those reported in Sweden (46.3% 677CC, 43.4% 677CT, and 10.3% 677TT) in the mucosa of patients with colorectal cancer [13]; 28.6% 677CC, 44.9% 677CT, and 26.5% 677TT reported in patients with lymphoblastic leukemia in the Chinese population [17]; 51.4% 677CT, 41.4% 677CT, and 7.1% 677TT reported in Brazil in patients with chronic hepatitis C [14]; and 7.8% 677TT reported in children in the USA [18].…”

Section: Discussionsupporting

confidence: 86%

“…The plasma concentration of homocysteine is lower in sub-Saharan African populations compared to the Mediterranean [5, 6]. This difference is due to the variable frequency of MTHFR polymorphisms between Westerners and Africans [7]. The frequency of the C677T allele varies with age in the African population.…”

Section: Introductionmentioning

confidence: 99%

“…However, Chillemi et al (2005) suggested that the determination of plasma homocysteine levels could be used as a measure of the severity of malaria infection [7]. The genes involved in the metabolism of homocysteine are highly polymorphic but only four major SNPs significantly influence it.…”

Section: Introductionmentioning

confidence: 99%

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Major Polymorphisms of Genes Involved in Homocysteine Metabolism in Malaria Patients in Ouagadougou, Burkina Faso

Yaméogo

BAZIE

Ouattara

et al. 2017

Malaria Research and Treatment

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This study analyzed the four main polymorphisms of the genes in homocysteine metabolism in malaria patients. Forty-two randomly selected subjects, diagnosed positive for Plasmodium falciparum, were included. The four genotypes were detected by real-time PCR using the MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, and MTRR 66A>G detection kit (Sacace Biotechnologies REF: T01002-96-S). The results revealed frequencies of 90% 677CC, 10% 677CT, and 00% 677TT for MTHFR C677T; 78.6% 1298AA, 19% 1298AC, and 2.4% 1298CC for MTHFR A1298C; 61.9% 2756AA, 33.3% 2756AG, and 4.8% 2756GG for MTR A2756G; and 50% of 66AA, 45% of 66AG, and 5% of 66GG for MTRR A66G. Correlations were found between A2756G MTR genotypes and parasitaemia (P = 0.02), MTRR A66G and hemoglobin genotypes (P = 0.009), and MTHFR A1298C and sex (P = 0.01). This study demonstrated for the first time an association between the A2756G MTR alleles and Plasmodium falciparum malaria in Burkina Faso and gave an overview of the genotypic distribution of the major SNPs influencing the metabolism of homocysteine.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Major Polymorphisms of Genes Involved in Homocysteine Metabolism in Malaria Patients in Ouagadougou, Burkina Faso

Yaméogo

BAZIE

Ouattara

et al. 2017

Malaria Research and Treatment

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“…L-Cys, the precursor of glutathione is degraded to Cys-gly, which again breaks into L-Cys and glycine. [9][10][11][12] Vitamin B 6 , B 9 and B 12 (cofactors) have very important roles in the metabolism of homocysteine. Decrease in B-vitamins caused due to dietary nutritional deficiency disturb the re-methylation process and influence the formation of t-Hcy and subsequent formation of cystathionine, L-Cys and GSH.…”

Section: Introductionmentioning

confidence: 99%

Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India

Mukherjee

Manna

Chakraborty

et al. 2016

Journal of Environmental Science and Health, Part A

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Chronic arsenic toxicity is a serious environmental health problem across the world. Bangladesh and India (particularly the state of West Bengal) are the worst affected countries with such problem. The present study reports plasma-aminothiols (p-aminothiols) like L-cysteine (L-Cys), cysteinyl glycine (Cys-gly), total homocysteine (t-Hcy) and glutathione (GSH) status, and the inverse relationship of t-Hcy with B-vitamins (B1, B6, B9 and B12) in arsenic exposed population of West Bengal, India. Reverse phase HPLC was used to measure p-aminothiols and serum B-vitamins in different arsenic exposed population. Arsenic in drinking water and urine were measured by flow injection analysis system - Atomic Absorption Spectrometry (FIAS-AAS) and Transversely heated graphite atomizer (THGA-AAS) techniques, respectively. Water arsenic exposure was >50 µg/L in 50% population, of which majority (33.58%) belong to the range of >50-500 µg/L and more than 8% were even >1000 µg/L. Urine arsenic (µg/g creatinine) levels increased with arsenic exposure. The variability among p-aminothiols was also observed with higher exposure to arsenic in drinking water. A significant difference between exposed and control population was noticed for plasma L-Cys. The difference of B-vitamins between the population exposed to <50 and >50 µg/L arsenic in drinking water was also found to be significant. B9 and B12 deficiency with increased consumption of arsenic in water corroborates the anemic conditions commonly observed among arsenic exposed population. The aminothiol status indicated oxidative stress in exposed population. This study demonstrated progressive increase in plasma t-Hcy as well as inverse relationships of serum B-vitamins with increased water arsenic concentration.

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Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas

Musumeci¹,

Vadalà

Tringali³

et al. 2009

J Bone Miner Metab

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The aim of this study was to determine the prevalence of known gene polymorphisms associated with osteoporosis in postmenopausal normal women from Burkina Faso and Sicily, compared to postmenopausal Sicilian women with osteoporosis, and to establish the weight of environmental factors in the mechanism of osteoporosis. Bone mass density (BMD) was measured by phalangeal quantitative ultrasound (QUS) in Burkinabe woman and by the dual X-ray absorptiometry at the femoral neck in Sicilian women. The polymorphisms of the vitamin D receptor (VDR) gene, estrogen receptor (ESR) gene, calcitonin receptor (CTR) gene and COL1A1 collagen gene were characterized by PCR. The social characteristics of studied women were evaluated by a specific questionnaire. The observed percentages of single specific polymorphisms did not differ from that expected with exception of VDR B allele and ESR X and P allele in Burkinabe and Sicilian women, respectively. Association analyses and multivariate two-step regression model of social and molecular parameters, demonstrated that in comparison to the VDR, ESR, CTR polymorphisms, physical activities and healthy diet, associated with outdoor work are the best favourable prognostic factors for osteoporosis. A diet rich in calcium, other minerals and vitamin D in association with physical activity represents the most effective way to maintain not only a healthy bone structure but also an acceptable BMD. This is particularly true for Sub-Saharan women.

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Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso

Abstract: The elevated levels of homocysteine in the postmenopausal women of Burkina Faso must be viewed as a characteristic of older age and its metabolic consequences.

Cited by 16 publications

References 32 publications

Major Polymorphisms of Genes Involved in Homocysteine Metabolism in Malaria Patients in Ouagadougou, Burkina Faso

Major Polymorphisms of Genes Involved in Homocysteine Metabolism in Malaria Patients in Ouagadougou, Burkina Faso

Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India

Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas

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