Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh

Huda, Nazmul; Hossain, Sabbir; Rahman, Mashiur; Karim, Md. Rezaul; Islam, Khairul; Mamun, Abdullah Al; Hossain, Md. Imam; Mohanto, Nayan Chandra; Alam, Sarwar; Aktar, Sharmin; Arefin, Afroza; Ali, Nurshad; Salam, Kazi Abdus; Aziz, Abdul Rashid Abdul; Saud, Zahangir Alam; Miyataka, Hideki; Himeno, Seiichiro; Hossain, Khaled

doi:10.1016/j.taap.2014.09.011

Cited by 46 publications

(31 citation statements)

References 45 publications

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“…Bellavia et al [51] showed an association between particulate-matter-mediated hypomethylation and BP. Similar to the results of our previous research [18, 35, 37], in the present study we also observed that the average levels of BP and the percentage of hypertensive patients were higher in the arsenic-endemic areas compared to the non-endemic area, and the average levels of SBP and the percentage of hypertensive patients were higher in the females than the males in the arsenic-endemic areas (Table 2). …”

Section: Discussionsupporting

confidence: 92%

“…The levels of DBP and SBP of the subjects in the arsenic-endemic areas were significantly ( p < 0.001) higher than those of the subjects in the non-endemic area, as we reported [18, 35, 37]. Accordingly, the percentage of hypertensive subjects was also higher in the arsenic-endemic areas compared to the non-endemic area.…”

Section: Resultssupporting

confidence: 60%

“…The human subjects who participated in this study gave their written consent. The arsenic-endemic and non-endemic areas and study subjects were selected as described [18, 33–38]. Arsenic-endemic study areas were selected from the north-west region of Bangladesh that included Marua in Jessore, Dutpatila, Jajri, Vultie and Kestopur in Chuadanga and Bheramara in Kushtia districts.…”

Section: Methodsmentioning

confidence: 99%

“…Fasting blood samples (5–7 mL) were collected in EDTA-containing blood collection tubes from each individual by venipuncture as described [18, 37]. From the EDTA-treated blood, 100 μl was taken and DNA was extracted with the use of a DNeasy Blood and Tissue kit (Qiagen, Valencia, CA, USA) according to the manufacturer’s recommendations.…”

Section: Methodsmentioning

confidence: 99%

“…Elevated blood pressure (BP) or hypertension is a potent risk factor for CVD, which is the main cause of mortality worldwide. We and other groups have shown that chronic exposure to arsenic is associated with hypertension and circulating biomarkers of CVD [18, 19]. …”

Section: Introductionmentioning

confidence: 99%

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Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

et al. 2017

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BackgroundChronic exposure to arsenic is associated with cancer and hypertension. Growing evidence suggests that altered methylation in long interspersed nuclear element-1 (LINE-1) is involved in many types of disorders, including cardiovascular disease. Here we evaluated the association between arsenic exposure and LINE-1 methylation levels, especially in relation to blood pressure (BP).MethodsA total of 236 subjects (175 from arsenic-endemic areas and 61 from a non-endemic area) in rural Bangladesh were recruited. The subjects’ arsenic exposure levels (i.e., drinking water, hair and nail arsenic concentrations) were measured by inductively coupled plasma mass spectroscopy. The subjects’ LINE-1 methylation levels were determined by pyrosequencing.ResultsThe average LINE-1 methylation levels of the subjects living in the arsenic-endemic areas were significantly (p < 0.01) lower than those of the subjects living in the non-endemic area. In a sex-stratified analysis, the arsenic exposure levels in female but not male subjects showed a significant inverse association with LINE-1 methylation levels before (water arsenic: p < 0.01, hair arsenic: p < 0.05, nail arsenic: p < 0.001) and after (water arsenic: p < 0.01, hair arsenic: p < 0.05, nail arsenic: p < 0.001) adjustment for age, body mass index and smoking. Analyses examining interactions among arsenic levels, BP and LINE-1 methylation showed that arsenic-related elevated levels of BP were associated with LINE-1 hypomethylation.ConclusionsOur findings demonstrated that chronic exposure to arsenic was inversely associated with LINE-1 methylation levels in blood leukocyte DNA and this was more pronounced in females than males; in addition, the decreased levels of LINE-1 methylation might be involved in the arsenic-induced elevation of BP.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0231-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

Section: Resultssupporting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

et al. 2017

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Uric acid quantification in fingernail of gout patients and healthy volunteers using HPLC‐UV

Shi

Jin

et al. 2016

Biomedical Chromatography

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The presence of elevated uric acid (UA) levels is a sign of gout, that is, hyperuricemia. In this study the monitoring of the UA levels in less-invasive biological samples, such as the human fingernail, is suggested for the diagnosis and therapy of gout. Twenty-six healthy volunteers (HV) and 22 gout patients (GP) were studied. The UA was extracted from human fingernail samples, then separated on an Inertsil ODS-3 column (250 × 4.6 mm i.d., 4.0 μm, GL Sciences) by isocratic elution using methanol-74 mm phosphate buffer (pH 2.2) 2:98 (v/v). A UV detector was used to monitor the samples at 284 nm. Using the developed method, different UA concentrations were found in the GP and HV. When comparing the concentrations from GP with those from HV, a statistically significant correlation was observed between the UA (p < 0.01). In this study, the UA was confirmed as a potential biomarker for the diagnosis and therapy of gout. We have developed a novel sensitive, and simple method for the determination of UA in the fingernails of GP and HV. The human fingernail may serve as a noninvasive biosample for the diagnosis of gout. Copyright © 2016 John Wiley & Sons, Ltd.

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Integrative metabolomics and network pharmacology to study the preventative impact of dioscin treatment on hyperuricemia

Wang

et al. 2023

Biomedical Chromatography

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This work aims to combine network pharmacology and metabolomics to explore the mechanism of action of dioscin on hyperuricemia (HUA). The preventative impact of dioscin on HUA and its putative mechanism were examined using network pharmacological analysis and metabonomics. Network pharmacology study further pointed out the potential targets of dioscin after a review of the relevant biomarker pathways discovered by metabolomic analysis. Molecular docking was then used to examine how the active chemicals interacted with the target proteins. The therapeutic effect of dioscin on HUA was shown to be mediated by 13 potentially important metabolites as a result of metabonomic research. Most of these metabolites are regulated after dioscin therapy to help patients recover. Based on network pharmacology, we identified 10 central genes, which is partly in agreement with metabolomics data. Using metabolomics and network pharmacology, this study investigated the primary targets and mechanisms of dioscin in the treatment of HUA. It is advantageous that dioscin has been developed as an additional drug for the treatment of HUA.

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Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh

Cited by 46 publications

References 45 publications

Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Uric acid quantification in fingernail of gout patients and healthy volunteers using HPLC‐UV

Integrative metabolomics and network pharmacology to study the preventative impact of dioscin treatment on hyperuricemia

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