Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome

Alexander, Richard B.; Ponniah, Sathibalan; Hasday, Jeffrey D.; Hebel, J. Richard

doi:10.1016/s0090-4295(98)00390-2

Cited by 215 publications

(145 citation statements)

References 16 publications

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“…They act locally over short cellular distances as initiators and modulators of immune and inflammatory responses. Increased concentrations of TNF-α and IL-1β have been reported in seminal plasma and EPS in CPPS (9,16). These cytokines could up-regulate COX-2 gene expression levels, which may further contribute to the development of inflammation (10).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA)

Zhao

Zhang

et al. 2009

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

“…Patients with CPPS have higher levels of tumor necrosis factor-α (TNF-α) and of the inflammatory cytokine interleukin-1β (IL-1β) in EPS and semen compared to normal men (9). This cytokine could up-regulate the level of cyclooxygenase-2 (COX-2) gene expression, which may further contribute to the development of inflammation (10).…”

Section: Introductionmentioning

confidence: 99%

Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA)

Zhao

Zhang

et al. 2009

Braz J Med Biol Res

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“…10,12,13 The remaining 60-95% cases of clinical prostatitis (categories IIIA and IIIB) may involve (i) hormonal imbalance; 14,15 (ii) neurological dysfunction; 16,17 (iii) a-adrenergic system abnormalities; [18][19][20] (iv) urinary reflux into the prostate; [21][22][23] (v) inappropriate cytokine release [24][25][26][27][28][29][30][31][32] and/or (vi) an autoimmune response. [33][34][35][36][37] The patients typically have repeat episodes of prostatitis and therapy is 'hit or miss'.…”

Section: Introductionmentioning

confidence: 99%

Experimental rodent models of prostatitis: limitations and potential

Vykhovanets

Resnick

MacLennan

et al. 2007

Prostate Cancer Prostatic Dis

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Prostatitis is a polyetiological inflammation of the prostate gland in men characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction. Histologically prostatitis is characterized by poly-and mononuclear cell infiltrates (neutrophils, lymphocytes, macrophages and plasma cells) in the stromal connective tissue around the acini or ducts. Prostatitis is an important worldwide health problem in men. The pathogenesis and diagnostic criteria for the condition are obscure, with the result that the development of management programs for this condition has been hindered. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This review examines a number of experimental rodent models of prostatitis and evaluates their advantages and limitations.

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“…Although the classic inflammatory mediators and effects of acidosis have been investigated intensively, we are just beginning to understand the importance of cytokines for the development of pain and hyperalgesia as well as their mechanisms of action on nociceptors (for review, see Kress and Reeh, 1996). The most detailed information is available for the proinflammatory cytokines IL-1␤, IL-6, and IL-8 and tumor necrosis factor (TNF)-␣, which have been traced in inflamed tissue and for which a role in nociception has been established (Alexander et al, 1998;Watkins and Maier, 1999). In tumor patients, cytokines are of dual importance.…”

mentioning

confidence: 99%

Involvement of the Proinflammatory Cytokines Tumor Necrosis Factor-α, IL-1β, and IL-6 But Not IL-8 in the Development of Heat Hyperalgesia: Effects on Heat-Evoked Calcitonin Gene-Related Peptide Release from Rat Skin

2000

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Proinflammatory cytokines contribute to the development of inflammatory and neuropathic pain and hyperalgesia in many in vivo models. The rat skin model was used to investigate the effects of proinflammatory cytokines on the basal and heatevoked release of calcitonin gene-related peptide from nociceptors in vitro. In contrast to the excitatory effects of cytokines observed in vivo, none of the cytokines tested evoked any calcitonin gene-related peptide (CGRP) release at normal skin temperature of 32°C. However, the cytokines IL-1␤, tumor necrosis factor (TNF)-␣, and IL-6 but not IL-8 induced a pronounced and transient sensitization of the heat-evoked CGRP release from nociceptors in vitro. This heat sensitization was dose dependent, with EC 50 for IL-1␤ of 2.7 ng/ml and for TNF-␣ of 3.1 ng/ml. The maximum IL-1␤ effect reached almost 600% of the heat-evoked release, and the maximum TNF-␣ effect induced a rise in CGRP release of 350%. In contrast to IL-1␤ and TNF-␣, IL-6 did not induce heat sensitization when applied alone but was only effective in the presence of soluble IL-6 receptor. This suggests a constitutive expression of signaling receptors for TNF and IL-1␤ and the signal transduction molecule gp130 but not IL-6 receptor or IL-8 receptor. Furthermore, the acute cytokine signaling observed in the present study was independent of transcriptional pathways because sensitization occurred on short latency in vitro and under conditions that excluded chemotactic accumulation of immune cells from blood vessels. Our results demonstrate that interleukins may play an important role in the initiation of heat hyperalgesia in inflammation and neuropathy.

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Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome

Cited by 215 publications

References 16 publications

Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA)

Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA)

Experimental rodent models of prostatitis: limitations and potential

Involvement of the Proinflammatory Cytokines Tumor Necrosis Factor-α, IL-1β, and IL-6 But Not IL-8 in the Development of Heat Hyperalgesia: Effects on Heat-Evoked Calcitonin Gene-Related Peptide Release from Rat Skin

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