Elevated levels of soluble fibrin in patients with venous thromboembolism

Tsuji, Akiko; Wada, Hideo; Matsumoto, Toshifumi; Abe, Yasunori; Ota, Satoshi; Yamada, Norikazu; Sugiyama, Takashi; Sudo, Akihiro; Onishi, Katsuya; Nakatani, Kaname; Uchida, Atsushi; M, Ito; Suzuki, Koji; Nobori, Tsutomu

doi:10.1007/s12185-008-0173-5

Cited by 19 publications

(20 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An appropriate cut-off value for the diagnosis of VTE in patients without operation was reported to be 5.9 lg/ml in SF and 4.8 lg/ml in D-dimer with different assays (data from SF and D-dimer by different assays were similar; unpublished data) [25]. In this study, more than 11.9 lg/ml of SF on day 1 or more than 17.7 lg/ml of D-dimer on day 4 was suggested to be associated with DVT in the patients after surgery.…”

Section: Discussionmentioning

confidence: 97%

“…In previous reports [2,14,25], the high concentrations of SF and D-dimer could be considered to be markers of thrombosis including venous thromboembolism (VTE). An appropriate cut-off value for the diagnosis of VTE in patients without operation was reported to be 5.9 lg/ml in SF and 4.8 lg/ml in D-dimer with different assays (data from SF and D-dimer by different assays were similar; unpublished data) [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

et al. 2009

Self Cite

View full text Add to dashboard Cite

Soluble fibrin (SF) and D-dimer are considered to be useful for the diagnosis of thrombosis; however, the efficacy of the diagnosis of deep vein thrombosis (DVT) after orthopaedic surgery by SF and D-dimer is still not well established. The present study was designed to evaluate the efficacy of SF and D-dimer in the diagnosis of DVT after orthopaedic surgery. The plasma concentrations of SF and D-dimer were measured in 99 patients following orthopaedic surgery. The plasma concentrations of D-dimer and SF in patients undergoing orthopaedic surgery were markedly high in comparison to healthy volunteers, and these markers were increased after surgery. The plasma concentrations of D-dimer were significantly higher in patients with DVT than in those without DVT at days 4, 7, 10 and 14, and those of SF were significantly higher in patients with DVT than in those without DVT at days 1, 4 and 14. A receiver operating characteristic (ROC) analysis of SF and D-dimer for diagnosis of DVT after surgery generated an ROC curve that showed SF to be better than D-dimer at day 1, while D-dimer was better than SF at day 4. In addition, less than 7.2 microg/ml of D-dimer or 3.6 microg/ml of SF at day 1 after surgery, or less than 7.0 microg/ml of D-dimer at day 4 excluded DVT. These findings suggest that the D-dimer and SF are useful for the diagnosis and exclusion of DVT after orthopaedic surgery.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…Plasma levels of FDP, D-dimer, SF, plasmin plasmin inhibitor complex (PPIC) and plasminogen activator inhibitor-I (PAI-I) were measured by the latex agglutination method using Nanopia FDP, Nanopia D-dimer, Nanopia SF (Sekisui Medical), LPIAACE PPIII (Mitsubishi Chemical Medience, Tokyo, Japan) and LPIA-tPAI test (Mitsubishi Chemical Medience), respectively [20]. The plasma levels of AT were measured using a Testzym S AT III kit (Sekisui Medical).…”

Section: Methodsmentioning

confidence: 99%

Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux

et al. 2012

Self Cite

View full text Add to dashboard Cite

We evaluated hemostatic markers in patients who underwent major orthopedic surgery, including total hip and total knee arthroplasty, and were treated for the prophylaxis of deep vein thrombosis (DVT) with or without fondaparinux (anti-Xa group, n = 98 and without anti-Xa group, n = 20). The frequency of DVT was significantly higher in the without anti-Xa group than in the anti-Xa group, but the reduction of hemoglobin and fibrinolytic marker levels was significantly lower in the without anti-Xa group than in the anti-Xa group. Eighteen patients in the anti-Xa group showed a reduction in hemoglobin of more than 2 g/dl, and those individuals were considered to be the increased bleeding (IB) group. The concentration of fibrinolytic markers in the anti-Xa group was significantly higher in the IB group than in the non-IB group. There were also no significant differences in the levels of anti-Xa activity, plasminogen activator inhibitor-I, soluble fibrin and antithrombin between the IB and non-IB groups. In conclusion, elevated fibrinolysis induced by increased bleeding may lead to further increases in bleeding in patients receiving thromboprophylaxis with fondaparinux following major orthopedic surgery.

show abstract

“…Plasma levels of FDP, D-dimer and SF were measured by the latex agglutination method using Nanopia FDP, Nanopia D-dimer and Nanopia SF (Sekisui Medical), respectively [13]. The plasma levels of AT were measured by chromogenic substrate using a Testzym S ATIII kit (Sekisui Medical).…”

Section: Methodsmentioning

confidence: 99%

Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement

et al. 2011

Self Cite

View full text Add to dashboard Cite

The efficacy of measuring anti-Xa activity was evaluated in major orthopedic surgery patients receiving thrombo-prophylaxis with Fondaparinux. Although 98 orthopedic patients including those receiving total hip replacement (THR) and total knee replacement (TKR) were treated with 1.5 mg of Fondaparinux for prophylaxis of deep vein thrombosis (DVT). Sixteen patients developed DVT, but none was associated with a fatal pulmonary embolism. There was a wide range of anti-Xa activity, but there were no patients with less than 0.15 mg/l or more than 0.90 mg/l. Anti-Xa activity gradually increased from days 1 to 8 and showed no significant difference between patients with and without DVT. Anti-Xa activity was correlated with weight, height, body mass index, and antithrombin activity. Postoperative plasma levels of D: -dimer and soluble fibrin (SF) were markedly high, and those were significantly reduced at days 1 and 4 of treatment with Fondaparinux. Plasma levels of SF were significantly reduced at days 8 and 15, but D: -dimer was not. These findings suggested that there was continued thrombin generation after the injection of Fondaparinux until day 8 and secondary fibrinolysis occurred on day 8. In conclusion, 1.5 mg of Fondaparinux may not be sufficient for the prophylaxis of silent DVT, but it was found to be useful for that of fatal pulmonary embolism. Consequently, monitoring anti-Xa activity may be unnecessary for the administration of Fondaparinux at such doses.

show abstract

Elevated levels of soluble fibrin in patients with venous thromboembolism

Cited by 19 publications

References 33 publications

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux

Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement

Contact Info

Product

Resources

About