Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies

Ueland, Thor; Estensen, Mette-Elise; Grindheim, Guro; Bollerslev, Jens; Henriksen, Tore; Aukrust, Pål; Aakhus, Svend; Gullestad, Lars; Lekva, Tove

doi:10.1097/hjh.0000000000002362

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…In addition, we reported no differences between women with early-onset PE (11 cases) and women with late-onset PE (17 cases). Our results are in line with the findings of Ueland et al, who documented no significant differences in circulating DKK1 levels in a cohort consisting of 61 women with NP and 34 women with PE at term (weeks 35 – 36) 24 . On the contrary, Tayyar and colleagues showed increased serum DKK1 levels in women with early-onset PE (27 cases) compared with NP women (27 cases).…”

Section: Discussionsupporting

confidence: 93%

Comparison of Maternal Serum Levels and Placental mRNA Levels of Dickkopf-1 in Preeclamptic and Normal Pregnant Women at Delivery

Kasoha

Takács

Fackiner

et al. 2021

Geburtshilfe Frauenheilkd

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Background Preeclampsia remains a major cause of perinatal and maternal mortality and morbidity worldwide. Wnt/β-catenin signaling is known to be critically involved in placenta development processes. Dickkopf-1 (DKK1) is a key regulator of this transduction pathway. The aim of this study is to compare maternal serum DKK1 levels and placental mRNA levels of DKK1 and β-catenin in preeclamptic and normal pregnant women at delivery. Methods The present study included 30 women with preeclampsia and 30 women with normal pregnancy. Maternal serum DKK1 levels were measured by ELISA. Placental mRNA levels of DKK1 and β-catenin were detected using RT-PCR. Results Decreased maternal serum DKK1 levels were associated with worse maternal and fetal complications including HELLP syndrome, determination of one or more pathological symptom and IUGR diagnosis. No significant difference in maternal serum DKK1 levels was reported between preeclamptic women and women with normal pregnancy. Placental mRNA DKK1 levels were lower in preeclamptic women compared with normal pregnant women. Placental mRNA β-catenin levels showed no significant difference between two groups. Conclusions Our findings reported the aberrant placental mRNA DKK1 levels in patients with preeclampsia. In addition, worse preeclampsia features were associated with decreased maternal serum DKK1 levels. Hence, aberrant Wnt/β-catenin signaling might present a plausible mechanism in preeclampsia pathogenicity. Dysregulated expression of DKK1 at gene level in the placenta but not at protein level in the maternal serum might confirm the notion that preeclampsia is a type of placenta-derived disease.

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Section: Discussionsupporting

confidence: 93%