Elevated Levels of Tumor Necrosis Factor-Alpha in Periradicular Fat Tissue in Patients With Radiculopathy From Herniated Disc

Genevay, Stéphane; Finckh, Axel; Payer, Michael; Mézin, Françoise; Tessitore, Enrico; Gabay, Cem; Guerne, Pierre‐André

doi:10.1097/brs.0b013e318183bb86

Cited by 73 publications

(51 citation statements)

References 29 publications

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“…In recent clinical studies, elevated levels of proinflammatory cytokines (IFN-c, IL-1b, IL-2, IL-6 and TNF-a) correlated with elevated pain scores in various types of neurological and rheumatologic disorders [11][12][13][14][15][16][17][18][19][20]. In addition, we found that intervertebral TNF-a levels correlate with preoperative pain in LDH patients [21].…”

Section: Discussionsupporting

confidence: 52%

Elevated IL-1β and IL-6 levels in lumbar herniated discs in patients with sciatic pain

et al. 2012

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Purpose Previous experimental models have shown that proinflammatory cytokines modulate peripheral and central nociception. However, the direct correlation between inflammation and pain in patients remains unclear. Our aim is to correlate the levels of inflammation in the spine with pre-and postoperative pain scores after discectomy. Methods Paravertebral muscle, annulus fibrosus (AF) and nucleus pulposus (NP) biopsies were intraoperatively collected from ten lumbar disc hernia (LDH) patients suffering from chronic sciatic pain and, as painless controls, five scoliosis patients. IL-1b and IL-6 expressions in these biopsies were assessed by qPCR and western blot. The amount of pain, indicated on a 0-10 point visual analogue scale (VAS), was assessed 1 day before surgery and 6 weeks and 1 year after surgery. For analysis purposes, LDH patients were grouped into painful (VAS C 3.5) and non-painful (VAS \ 3.5). LDH painful patient group showed a onefold increased mRNA expression of IL-1b in the NP, and IL-6 in the AF and NP (p \ 0.05 vs. controls).Results By western blot analysis, both cytokines were clearly visible in all LDH biopsies, but not in controls. However, cytokine expression of the painful patient group did not differ from those of the non-painful patient group. In addition, there was no correlation between VAS scores and either marker. Conclusions These findings support the idea that LDH is accompanied by a local inflammatory process. Yet, the lack of correlation between IL-1b or IL-6 expression and the severity pain suggests that these cytokines may not play a leading role in maintaining a pain generating network.

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Section: Discussionsupporting

confidence: 52%

Elevated IL-1β and IL-6 levels in lumbar herniated discs in patients with sciatic pain

et al. 2012

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“…The sciatica syndrome is characterized by low back pain with radiculopathy [12]. Sciatica often has a lengthy course and causes prolonged disability [21,41].…”

Section: Introductionmentioning

confidence: 99%

Symptomatic disc herniation and serum lipid levels

et al. 2011

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Insufficient blood supply to the intervertebral disc (IVD) has been proposed to play a role as causative factor in IVD degeneration. There is an association between IVD diseases and increased risk of dying of ischaemic heart disease. Obesity and tobacco are potential risk factors for degenerative IVD disease. High blood cholesterol and triglycerides serum levels are risk factors for atherosclerosis, and could be responsible for a decreased in the blood supply to the already poor vascularized IVD. We performed a frequency-matched casecontrol study to determine the serum levels of patients with symptomatic herniated lumbar disc. We examined the fasting serum lipid levels in 384 subjects who were operated at our institution. Group 1 included 169 consecutive patients (115 men and 54 women; mean age: 59.1 years, range 29-85) who underwent surgery for symptomatic disc herniation. Group 2 (control group) included 169 patients (115 men and 54 women; mean age: 61 years, range 26-86) who underwent arthroscopic meniscectomy for a meniscal tear in the same period. These patients were frequency-matched by age (within 3 years) and gender with patients of Group 1. Sera were extracted from blood samples and the concentrations of total cholesterol (TC) and triglycerides (TG) were determined. When comparing the two groups, patients with symptomatic herniated lumbar disc showed statistically significant higher triglyceride concentration (P = 0.02) and total cholesterol concentration (P = 0.01). Serum lipid levels may be a risk factor for IVD pathology. An enhanced understanding of these factors holds the promise of new approaches to the prevention and management of IVD pathology.

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“…Inflammation of the spinal nerve root induced by autologous NP has been documented by many experimental animal studies [21] . Results of the current study support the concept that nerve inflammatory responses may be associated with NP leakage.…”

Section: Discussionmentioning

confidence: 99%

Effects of degenerative autologous nucleus pulposus on the lumbar sympathetic trunk: Sympathetic inflammation in rats

Tang

Bian

Guo

et al. 2017

Transl. Neurosci. Clin.

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Objective:We have reported the presence of discogenic visceral pain secondary to anterior herniation of the lumbar disc. The aim of this study was to observe the inflammatory response of the sympathetic trunk to an autologous degenerative nucleus pulposus (NP) injection under fluoroscopy. Methods: A total of 72 rats were used. In 24 rats, the autologous NP suspension was injected into the right sympathetic trunk. Next, food intake and body weight of each rat were monitored for 14 days. Fourteen days after the injection, the right lumbar sympathetic trunk was harvested for histological assessment, and protein levels of IL-1 β, IL-6, and TNF-α were quantified via ELISA. Results: In the NP-treated group, endoneural hyperemia and intensive infiltration of inflammatory cells could be identified in sections of the sympathetic trunk by the hematoxylin and eosin (H&E) stain. Meanwhile, elevated concentrations of IL-1 β, IL-6, and TNF-α were determined in the sympathetic trunk of the NP group as compared to that of the naïve and control groups, which indicated the development of an inflammatory response. Furthermore, food intake and body weight of rats in the NP group decreased significantly. Conclusions:The results indicated that an inflammatory response in the sympathetic trunk can be caused by anterior herniation of the lumbar disc, which can generate a sympathetic inflammatory pain response.Citation Tang YZ, Bian JJ, Guo YN, Sun CL, Wei Y, Li XH, Ni JX. Effects of degenerative autologous nucleus pulposus on lumbar sympathetic trunk in rats: sympathetic inflammation. Transl. Neurosci. Clin. 2017, 3(4): 213-219.

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Elevated Levels of Tumor Necrosis Factor-Alpha in Periradicular Fat Tissue in Patients With Radiculopathy From Herniated Disc

Abstract: Higher concentrations of TNF-alpha were found in EF from patients with radiculopathy from HD compared with patients suffering from other type of back pain. These results support the role of TNF-alpha in the pathogenesis of radiculopathy from HD.

Cited by 73 publications

References 29 publications

Elevated IL-1β and IL-6 levels in lumbar herniated discs in patients with sciatic pain

Elevated IL-1β and IL-6 levels in lumbar herniated discs in patients with sciatic pain

Symptomatic disc herniation and serum lipid levels

Effects of degenerative autologous nucleus pulposus on the lumbar sympathetic trunk: Sympathetic inflammation in rats

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