Elevated Levels of Tumor Necrosis Factor-α in the Nephrotic Syndrome in Humans

Suranyi, Michael; Guasch, Antonio; Hall, Bruce M.; Myers, Bryan D.

doi:10.1016/s0272-6386(12)80742-6

Cited by 160 publications

(125 citation statements)

References 30 publications

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“…Polymorphism at position 308 of the TNF-a promoter, representing G to A base transitions, has been linked to increased TNF transcription [17,27]. Elevation of TNF-a has been found in the plasma and urine of patients with INS [28]. Earlier studies have shown increase of TNF-a synthesis and gene expression in patients with idiopathic nephrotic syndrome and focal glomerular sclerosis [29,30].…”

Section: Discussionmentioning

confidence: 99%

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

et al. 2011

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“…Intestinal edema developing secondary to massive proteinuria-associated hypoalbuminemia reduces nutrient absorption and leads to malnutrition and activation of inflammatory cascade. Various inflammatory mediators (such as TNF α) exhibit a negative inotropic effect on the myocardium (5,18,19). In this way, malnutrition and inflammation lead to an increase in cardiovascular events incidence in the NS patient group.…”

Section: Discussionmentioning

confidence: 99%

“…Proteinuria in NS patients causes inflammatory cytokine release during endothelial injury, tubular reabsorption and tubular catabolism (23,24). In addition, malnutrition developing secondary to hypoalbuminemia leads to inflammatory cascade activation and cytokine release (5,18,19). Studies have shown that inflammatory cytokines cause myocardial injury (5).…”

Section: Discussionmentioning

confidence: 99%

Presence of fragmented QRS and its correlation with myocardial performance index in patients with nephrotic syndrome

Özkan

Adar²,

Ulusoy³

et al. 2014

Anadolu Kardiyol Derg

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Objective: More cardiovascular events are seen in nephrotic syndrome (NS) patients than in the normal population. Fragmented QRS (fQRS) includes various RSR' patterns with different morphologies of the QRS complexes with or without the Q wave on a resting 12-lead ECG. A relationship between the presence of fQRS and myocardial function impairment has been shown in several studies. The purpose of this study was to evaluate the presence of fQRS in this patient group and the relationship with myocardial functions. Methods: Thirty-four NS patients were included in the cross-sectional study. Demographic data were recorded, and electrocardiograms (ECGs) were analyzed for the presence of fQRS following investigation of biochemical parameters and 24-h protein excretion. In addition to classic echocardiographic parameters, the myocardial performance (Tei index) was calculated as an indicator of cardiac function. For comparison of group's data Student's t-test and Mann-Whitney U test were used. Multiple linear regression analysis was performed for parameters affecting presence of fQRS. Results: We identified fQRS in half of our patients group. Patients with fQRS had significantly greater proteinuria level and Tei index than those without (p<0.05 and p<0.001, respectively). Tei index was also affected presence of fQRS (p<0.05, β=0.45, R 2 =0.32) and positively correlated with proteinuria levels (p<0.05 r=0.366). Conclusion: We demonstrated, for the first time in the literature, that the determination of fQRS in patients with NS in surface ECG, an easily accessible technique, can be used as a parameter in the prediction of myocardial functions. (Anadolu Kardiyol Derg 2014; 14: 450-5)

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“…NS'de kullanılması TNF'nin NS ve fibrozisteki rolünden kaynaklanmaktadır. 82 Anektodal raporlarda, adalimumabın remisyon indüksiyonundaki etkinliği bildirilmiştir. 83,84 TİAZOLİDİNEDİONLAR FDA tarafından Tip 2 diabetes mellitus tedavisinde kullanılmaları onaylanmıştır.…”

Section: Galaktozunclassified

A Brief Overview Of Childhood Nephrotic Syndrome: Review

Zeybek¹,

Gök²

2015

Turkiye Klinikleri J Nephrol

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Elevated Levels of Tumor Necrosis Factor-α in the Nephrotic Syndrome in Humans

Cited by 160 publications

References 30 publications

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

Presence of fragmented QRS and its correlation with myocardial performance index in patients with nephrotic syndrome

A Brief Overview Of Childhood Nephrotic Syndrome: Review

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