Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β

Zee, Hessel H. van der; Ruiter, L. de; Broecke, D.G. van den; Dik, Willem A.; Laman, Jon D.; Prens, Errol P.

doi:10.1111/j.1365-2133.2011.10254.x

Cited by 431 publications

(370 citation statements)

References 29 publications

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“…These include genetic predisposition, hormonal dysregulation and an aberrant immune response to commensal bacteria 7, 8, 9, 10. A number of exogenous influences have also been implicated in population‐based studies of HS, particularly smoking and obesity,11 although a causative relationship has not been established.…”

Section: Introductionmentioning

confidence: 99%

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

Delany

Gormley

Hughes

et al. 2017

Acad Dermatol Venereol

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BackgroundHidradenitis suppurativa (HS), a chronic inflammatory disease that affects apocrine gland–bearing skin, has a significant impact on patients' quality of life. Estimates of the epidemiologic prevalence of HS are highly variable, and clinical data on disease characteristics and patient burden of disease remain limited.ObjectiveThe primary objective of this study was to determine the number of patients with HS attending dermatology clinics in a hospital setting in Ireland (within a 6‐month time period). Secondary objectives included the assessment of disease characteristics and the collection of patient responses on disease burden and work productivity.MethodsThis was an epidemiologic, non‐interventional, cross‐sectional study across four dermatology clinics in Ireland over a 6‐month time period. The disease prevalence was estimated by calculating the percentage of total patients with a diagnosis of HS (the primary population) across the selected sites. Secondary analyses were performed using the full analysis set, which consisted of eligible adults (≥18 years of age) from the primary population who provided informed consent. Data from these analyses are presented as descriptive summary statistics, with the use of an analysis of covariance for continuous endpoints.ResultsThe prevalence of HS across the four selected sites was estimated at 1.4% (95% CI, 1.24–1.62). One hundred and fifty eligible patients comprised the full analysis set. The majority of participants were white (95.3%), female (70.0%), cigarette smokers (56.0%) and overweight or obese (body mass index ≥25 kg/m2, 81.8%). Most patients for whom data were available presented with Hurley stage II (50.4%), and more than a third of the full analysis set had a relative with HS (34.7%). Questionnaire responses revealed a profound impact on quality of life, including diminished work productivity and various psychological comorbidities.ConclusionThis study offers insight into the clinical features and disease burden of hidradenitis suppurativa in an Irish population.

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Section: Introductionmentioning

confidence: 99%

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

Delany

Gormley

Hughes

et al. 2017

Acad Dermatol Venereol

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“…Recently, it has been shown that the IL-23/Th17 pathway is overexpressed in hidradenitis suppurativa (29), and this provides a rationale for the use of biologicals interfering with the Th17 pathway, like ustekinumab (anti-IL-12/IL-23) and anakinra (IL-1Ra) (see http://clinicaltrials.gov/ct2/show/ NCT01704534?termϭhidradenitisϩsuppurativa&rankϭ11 and http://clinicaltrials.gov/ct2/show/NCT01558375?termϭhidraden itisϩsuppurativa&rankϭ12). Given the known suppressive effect of IFN-␥ on the expansion of Th17 cells (28), the absence of IFN-␥ production in affected skin (30) and circulating lymphocytes as found here suggests a role of defective Th1 responses for the overproduction of IL-17A.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Production Assays Reveal Discriminatory Immune Defects in Adults with Recurrent Infections and Noninfectious Inflammation

Oever¹,

Veerdonk²,

Joosten³

et al. 2014

Clin. Vaccine Immunol.

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Cytokine production assays have been primarily used in research settings studying novel immunodeficiencies. We sought to determine the diagnostic value of cytokine production assays in patients with recurrent and/or severe infectious diseases (IDs) without known immunodeficiencies and unclassified noninfectious inflammatory disorders (NIIDs). We retrospectively examined cytokine production in whole-blood and peripheral blood mononuclear cell samples from 157 adult patients. A cytokine production rate of <5% of that of healthy controls was considered defective. While monocyte-derived cytokine (tumor necrosis factor alpha [TNF-α], interleukin-1β [IL-1β], and IL-6) production was rarely affected, 30% of all included patients had deficient production of interferon gamma (IFN-γ), IL-17A, or IL-22. Twenty-five percent of the NIID patients displayed defective IFN-γ production, whereas IL-17A production was generally unaffected. In the group of ID patients, defective IFN-γ production was found in 19% and 14% of the patients with viral and bacterial infections, respectively, and in 38%, 24%, and 50% of patients with mycobacterial, mucocutaneous, and invasive fungal infections, respectively. Defective IL-17A and IL-22 production was mainly confined to ID patients with mucocutaneous fungal infections. In conclusion, cytokine production assays frequently detect defective Th1 responses in patients with mycobacterial or fungal infections, in contrast to patients with respiratory tract infections or isolated bacterial infections. Defective IL-17A and IL-22 production was primarily found in patients with fungal infections, while monocyte-derived cytokine production was unaffected. Thus, lymphocyte-derived cytokine production assays are helpful in the diagnostic workup of patients with recurrent infections and suspected immunodeficiencies and have the potential to reveal immune defects that might guide adjunctive immunomodulatory therapy.

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“…Több munkacsoport is megerősítette, hogy a léziós bőrben jelentősen emelkedett a TLR2, az IL-17A, az IL-1B, a TNFA és az IL-10 gének kifejeződése (4), melyek a jelen (TNF gátlók) és a jövő (IL-1 és IL-17 gátló) terápiás cél-pontjainak alapját adják (8). A sejtszintű karakterizálás során a gyulladásos infiltrátumban a neutrofilek és a hízó-sejtek mellett jelentős mennyiségben találtak IL-12-t és IL-23-at termelő makrofágokat a papilláris és a reticuláris dermisben, Il-1β-t termelő CD11c+ (dendritikus) sejteket, 130 (9).…”

Section: Gyulladásos Sejtek Hs-benunclassified

“…A sejtszintű karakterizálás során a gyulladásos infiltrátumban a neutrofilek és a hízó-sejtek mellett jelentős mennyiségben találtak IL-12-t és IL-23-at termelő makrofágokat a papilláris és a reticuláris dermisben, Il-1β-t termelő CD11c+ (dendritikus) sejteket, 130 (9). További megfigyelés a krónikus léziókban a CD20+ és a CD79a+ B sejtek, valamint a CD138+ plazmasejtek megjelenése, jelezve a patogenezis dinamizmusát (8). A TLR2 fokozott jelenléte a baktériumok és az azokból származó kismolekulák szerepét veti fel a betegség kialakulásá-ban/módosításában (3).…”

Section: Gyulladásos Sejtek Hs-benunclassified

Hidradenitis suppurativa: why isn’t it a form of acne?

Törőcsik¹,

Kinyó²,

Kovács³

et al. 2016

BVSZ

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ÖSSZEFOGLALÁSKey words: acne inversa, acne vulgaris, hidradenitis suppurativa 1. Patogenezis Acne inversa: miért nem acne és nem is hidradenitis?A betegség korábbi nevével, az acne inversával joggal leszámolva, hisz nem ott, nem akkor és nem úgy jelenik meg, mint a serdülőkori acne, sokak számára a jellegzetes lokalizációból adódóan egyértelmű patogenetikai tényező-ként az apokrin mirigyek foglalták el a központi helyet. A tünetek típusos intertriginózus megjelenése kétséget kizá-róan rámutat az adott terület jellegzetességeinek szerepére, melyek nagyban hozzájárulhatnak a betegség kialakulásá-hoz. Számos elmélet született már, részleges magyarázatot adva a hidradenitis suppurativa (HS) patogenezisére, mint például a fokozott mechanikai irritáció szerepe, vagy a terület eltérő higiénés jellemzői, immunológiai sajátossá-gai, melyben a fokozott nedvesség kaphat központi szerepet. Ugyanakkor a szövettani vizsgálatok alapján az apokrin mirigyek csak az előrehaladott formákban voltak érint-ve és akkor is sokkal inkább a végpontjai mint sem aktív szereplői voltak a patológiai folyamatoknak (1).Az utóbbi évek kutatásai a faggyúmirigyek szerepére is ráirányították a figyelmet, melyhez nagyban hozzájárultak azok a szövettani leletek, melyek a faggyúmirigyek elpusztulását már a HS kezdeti stádiumában leírták (2). A szövet-tani minták elemzésének másik szembetűnő lelete az acné-ből jól ismert follicularis hiperkeratinizáció/okklúzió volt, mely a folliculusok kitágulásához majd roncsolódásához vezet, így a baktériumokban gazdag törmelék a dermist infiltrálva annak gyulladását eredményezi felvetve, hogy a baktériumok és a különböző gyulladásos útvonalak éppúgy fontosak lehetnek ebben a betegségben is (1. ábra). A gyulladásban szerepet játszó sejteken az acnéban ismerthez hasonlóan, szintén fokozottan vannak jelen a Toll-like 129

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Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β

Abstract: This study shows for the first time that IL-1β, TNF-α and IL-10 levels are elevated in HS skin. These data provide a rationale for therapies with biologics targeting cytokines such as TNF-α and IL-1.

Cited by 431 publications

References 29 publications

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

Cytokine Production Assays Reveal Discriminatory Immune Defects in Adults with Recurrent Infections and Noninfectious Inflammation

Hidradenitis suppurativa: why isn’t it a form of acne?

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