Elevated Lipase during Initial Presentation of Ulcerative Colitis in a Pediatric Patient: Do We Check for It

Ray, Piyali; Arsdall, Melissa R Van

doi:10.1159/000450699

Cited by 5 publications

(9 citation statements)

References 8 publications

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“…There were only few cases of elevated pancreatic enzymes without any other symptoms of pancreatic disease in IBD children in the literature published in English [ 8 , 48 , 49 ]. Based on Martinelli study, 81.2% of patients with hyperamylasemia/hyperlipasemia (HA/HL) manifested active IBD as well as AP.…”

Section: Resultsmentioning

confidence: 99%

“…However, after 12 months follow up 68.7% of patients reached a complete remission in pancreatic involvement. In one case report, HL correlated with severity of UC and lipase activity decreased when remission of UC was achieved [ 49 ]. In other case report, elevated amylase activity was diagnosed as macroamylasemia [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…Most drugs used to treat IBD may be responsible for the development of AP. However, it is difficult to determine whether the pancreatitis is an extraintestinal manifestation of IBD or it is induced by drugs used in IBD therapy, especially at the onset of the IBD management [ 2 , 49 ]. In the pediatric population, the course of acute pancreatitis in most cases is mild, regardless of whether it is drug- induced or not [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic Disorders in Children with Inflammatory Bowel Disease

et al. 2021

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Background and Objectives: Inflammatory bowel disease (IBD) is a chronic condition and mainly affects the intestines, however, the involvement of the other organs of the gastrointestinal tract (upper part, pancreas, and liver) have been observed. The coexistence of IBD with pancreatic pathology is rare, however, it has been diagnosed more frequently during recent years in the pediatric population. This article reviews the current literature on the most common pancreatic diseases associated with IBD in the pediatric population and their relationship with IBD activity and treatment. Materials and Methods: We performed a systematic review of data from published studies on pancreatic disorders, also reported as extraintestinal manifestations (EIMs), among children with IBD. We searched PubMed and Web of Science to identify eligible studies published prior to 25 April 2020. Results: Forty-four papers were chosen for analysis after a detailed inspection, which aimed to keep only the research studies (case control studies and cohort studies) or case reports on children and only those which were written in English. The manifestations of IBD-associated pancreatic disorders range from asymptomatic increase in pancreatic enzymes activity to severe disease such as acute pancreatitis. Acute pancreatitis (AP) induced by drugs, mainly thiopurine, seems to be the most- often-reported pancreatic disease associated with IBD in children. AP associated with other than drug etiologies, and chronic pancreatitis (CP), are rarely observed in the course of pediatric IBD. The pancreatic involvement can be strictly related to the activity of IBD and can also precede the diagnosis of IBD in some pediatric patients. The course of AP is mild in most cases and may occasionally lead to the development of CP, mainly in cases with a genetic predisposition. Conclusions: The involvement of the pancreas in the course of IBD may be considered as an EIM or a separate co-morbid disease, but it can also be a side effect of IBD therapy, therefore a differential diagnosis should always be performed. As the number of IBD incidences with concomitant pancreatic diseases is constantly increasing in the pediatric population, it is important to include pancreatic enzymes level measurement in the workup of IBD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pancreatic Disorders in Children with Inflammatory Bowel Disease

et al. 2021

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“…The effect of inflammatory mediators and cytokines released from the inflamed gut on the pancreas may also contribute to pancreatic damage and leakage of pancreatic enzymes into the blood [ 83 , 86 , 87 ]. There are a few reports of elevated lipase in patients with IBD [ 83 , 86 , 88 , 89 ]. The study of Ray and van Arsdall reported that during the initial presentation of IBD in their patients, lipase was elevated to more than three times the upper limit of normal [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are a few reports of elevated lipase in patients with IBD [ 83 , 86 , 88 , 89 ]. The study of Ray and van Arsdall reported that during the initial presentation of IBD in their patients, lipase was elevated to more than three times the upper limit of normal [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease

Adamkova

Hradicka

Skalníková

et al. 2022

Veterinary Sciences

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Inflammatory bowel disease (IBD) is a group of disorders causing inflammation in the digestive tract. Recent data suggest that dysbiosis may play a pivotal role in the IBD pathogenesis. As microbiome-based therapeutics that modulate the gut ecology have been proposed as a novel strategy for preventing IBD, the aim of presenting study was to evaluate the dextran sulphate sodium (DSS) rat model mainly in terms of microbial shifts to confirm its suitability for dysbiosis study in IBD. Acute colitis was induced using 5% DSS solution for seven days and rats were euthanized five days after DSS removal. The faecal/caecal microbiota was analyzed by next generation sequencing. Disease activity index (DAI) score was evaluated daily. Blood and colon tissue immunophenotyping was assessed by flow cytometry and histological, haematological, and biochemical parameters were also evaluated. The colitis induction was reflected in a significantly higher DAI score and changes in all parameters measured. This study demonstrated significant shifts in the colitis-related microbial species after colitis induction. The characteristic inflammation-associated microbiota could be detected even after a five day-recovery period. Moreover, the DSS-model might contribute to an understanding of the effect of different treatments on extraintestinal organ impairments. The observation that certain bacterial species in the gut microbiota are associated with colitis raises the question of whether these organisms are contributors to, or a consequence of the disease. Despite some limitations, we confirmed the suitability of DSS-induced colitis model to monitor microbial changes during acute colitis, in order to test attractive new microbiome-based therapies.

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Pancreatic Involvement in Salmonella Infection: Myth or Reality?

Seow

Flynn

et al. 2022

SN Compr. Clin. Med.

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Elevated Lipase during Initial Presentation of Ulcerative Colitis in a Pediatric Patient: Do We Check for It

Cited by 5 publications

References 8 publications

Pancreatic Disorders in Children with Inflammatory Bowel Disease

Pancreatic Disorders in Children with Inflammatory Bowel Disease

Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease

Pancreatic Involvement in Salmonella Infection: Myth or Reality?

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