Elevated lipoprotein(a) levels in patients with acute myeloblastic leukaemia decrease after successful chemotherapeutic treatment

Niendorf, Axel; Stang, Andreas; Beisiegel, Ulrike; Peters, A; Nägele, Herbert; Gebhardt, Angelika; Kuse, R.

doi:10.1007/bf00180286

Cited by 16 publications

(6 citation statements)

References 18 publications

(11 reference statements)

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“…It has been reported that the serum Lp(a) level was high in subjects with leukemia, and after remission the level decrease [26]. In our present study, the serum Lp(a) level did not change after total prostatectomy in subjects without estrogen.…”

Section: Statistical Analysis Serum Lp(a)supporting

confidence: 49%

Reduction of Serum Lipoprotein (a) by Estrogen in Men with Prostatic Cancer.

1993

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Abstract. The catabolism of lipoprotein(a), Lp(a), remains unclear. Very recently we observed that estrogen, a hormone known to increase low-density lipoprotein (LDL) receptor activity, reduced serum Lp(a) levels in a man with familial hypercholesterolemia (FH) (JAMA 267: 2328(JAMA 267: , 1992. In the present study, we attempted to further evaluate this Lp(a)-lowering action of estrogen in men without FH. Seven men, aged 61-84 yr, treated with estrogen for prostatic cancer were the subjects and seven men who underwent surgical treatment without estrogen therapy served as controls. Fasting blood was collected before and 1-3 months after estrogen therapy, and serum Lp(a) levels and lipoprotein profiles were determined. Estrogen treatment caused significant changes in serum lipoproteins, i.e., decreases in LDL-cholesterol, and increases in high-density lipoprotein (HDL)-cholesterol. Serum triglyceride levels tended to increase. Serum apo A-1 underwent a two-fold increase, while apo B did not change. Serum Lp(a) levels ranged from 8 to 62 mg/dl. After estrogen treatment serum Lp(a) was reduced markedly, with a mean reduction of 81% (71-95%). Serum lipids, lipoproteins and Lp(a) did not change significantly in the controls. The results demonstrated a regulating effect of estrogen on serum Lp(a) levels, and the findings further suggested that Lp(a) is removed via LDL receptors. However, previous studies have shown that maneuvers causing a decrease in LDL-cholesterol do not always cause a reduction in serum Lp(a). Thus, our findings suggested the possible presence of a receptor which is estrogen-inducible and different from the LDL receptor. [6, 7] and cerebral arteries [8]. Moreover, the serum Lp(a) level is an indicator of the presence and severity of coronary artery disease [9]. Because of its clinical significance, it is very important to evaluate attempts to lower the serum Lp(a) concentration in vivo. The serum Lp(a) concentration is the result of a balance between synthesis and elimination. Lp(a) is mostly synthesized in the liver, however, the site of catabolism of Lp(a) remains unknown [2]. The LDL-receptor is a candidate for Lp(a) removal from the circulation. To investigate this possibility, several hypolipidemic agents, such as cholestyramine [10] and 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors [1 1, 12], which induce LDL receptor expression, have been used to lower

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Section: Statistical Analysis Serum Lp(a)supporting

confidence: 49%

Reduction of Serum Lipoprotein (a) by Estrogen in Men with Prostatic Cancer.

1993

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“…[6], the Lp(a) levels were enhanced initially, but after about 2 weeks of treatment Lp(a) levels started to decrease gradually to the original levels. It is well‐known that APL patients are metabolically unstable, which amongst other things is noticeable in the fluctuation of Lp(a) values [6], and elevated serum Lp(a) levels have been reported in leukaemia [14]. It cannot therefore be excluded that the disease did influence the effects of retinoids on lipoproteins and that the increase in Lp(a) is secondary to other changes.…”

Section: Effect Of Treatment With Placebo or Isotretinoin On Concentrmentioning

confidence: 99%

No short‐term effect of oral isotretinoin (13‐cis retinoic acid) on lipoprotein(a) and HDL subclasses LP‐A‐I and LP‐A‐I:A‐II in healthy volunteers

Neele¹,

Buytenhek²,

Staels

et al. 1999

Journal of Internal Medicine

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“…Plasma Lp(a) levels are typically elevated under conditions of physiologic stress, such as extended long-distance running (Cardoso et aI. 1994), pregnancy (Desoye et al 1987), and thoracic surgery (Maeda et al 1989), as well as in specific disease states such as cancer (Wright et al 1989, Niendorf et al 1992, Kokoglu et al 1994) and renal disease (Dieplinger et al 1993, Buggy et al 1993). This lipoprotein may play an important role in tissue synthesis and repair.…”

mentioning

confidence: 99%

Lipoprotein(a) in plasma, arterial wall, and thrombus from patients with aortic aneurysm

et al. 1997

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The plasma concentration of lipoprotein(a) [Lp(a)] is highly correlated with the incidence of cardiovascular and peripheral vascular disease. A positive physiological role for Lp(a) has not yet been clearly identified, although elevated plasma levels in pregnant women, long‐distance runners, subjects given growth hormone, patients after cardiovascular surgery, and patients with cancer, diabetes, or renal disease suggest its involvement in tissue synthesis and repair. The hypothesis that Lp(a) is involved in repair/reinforcement of the aorta was tested in 38 patients undergoing surgery for aortic aneurysm. In 29 patients 1 day before surgery, the mean plasma Lp(a) protein level was 10.7 mg/dl. At about 1, 2, and 8 weeks after surgery, the level was 14.1, 15.1, and 15.2 mg/dl, respectively. These levels are significantly higher than those of a comparable group of normal subjects (6.4 mg/dl; n = 274). Specimens of resected aortic aneurysm showed extensive medial degeneration, discontinuous elastic fibers, and deposition of mucopolysaccharides; these specimens were treated with a detergent‐containing buffer to extract entrapped lipoproteins. The mean Lp(a) protein level in aortic wall extracts was 14.6 ng/mg tissue; these individual values were significantly associated with plasma Lp(a) levels before surgery (r2= 0.31, p = 0.0003). The mean Lp(a) protein level in aortic thrombus extracts was substantially higher at 69.6 ng/mg tissue; these individual levels also were significantly associated with plasma Lp(a) concentrations before surgery (r2= 0.68, p < 0.0001). The observations that: (i) plasma Lp(a) protein is about 1.7‐fold higher in patients with aortic aneurysms than in normal subjects; and (ii) that Lp(a) protein in the aneurysmic thrombus is about 4.8‐fold higher than in the aortic wall suggest that this lipoprotein plays a significant and direct role in thrombus formation and in reinforcement of the aneurysmic aortic wall.

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Elevated lipoprotein(a) levels in patients with acute myeloblastic leukaemia decrease after successful chemotherapeutic treatment

Cited by 16 publications

References 18 publications

Reduction of Serum Lipoprotein (a) by Estrogen in Men with Prostatic Cancer.

Reduction of Serum Lipoprotein (a) by Estrogen in Men with Prostatic Cancer.

No short‐term effect of oral isotretinoin (13‐cis retinoic acid) on lipoprotein(a) and HDL subclasses LP‐A‐I and LP‐A‐I:A‐II in healthy volunteers

Lipoprotein(a) in plasma, arterial wall, and thrombus from patients with aortic aneurysm

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