Elevated manganese exposure and school-aged children's behavior: A gender-stratified analysis

Menezes-Filho, José A.; Carvalho-Vivas, Chrissie F. de; Viana, Gustavo F.S.; Ferreira, Júnia Raquel Dutra; Nunes, Lorena S.; Mergler, Donna; Abreu, Neander

doi:10.1016/j.neuro.2013.09.006

Cited by 80 publications

(46 citation statements)

References 29 publications

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“…We used the Virtual Radial Arm Maze (VRAM) test, a neurobehavioral animal-human analogue test, to evaluate visuospatial learning and memory. Given that previous studies of associations between Mn and neurobehavior found interactions by sex (Gunier et al 2015; Bouchard et al 2011; Riojas-Rodríguez et al 2010; Menezes-Filho et al 2014; Torres-Agustín et al 2013), we hypothesized that Mn associations would differ for girls and boys.…”

Section: Introductionmentioning

confidence: 99%

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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Background Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children. Objectives We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory. Methods Deciduous teeth were collected from 142 participants (ages 10–14 years) residing near varied ferro-manganese industry in Italy. Mn concentrations were measured in prenatal and postnatal tooth regions by laser ablation inductively coupled plasma mass spectrometry (ICP-MS). The Virtual Radial Arm Maze (VRAM), an animal-human analogue task, was used to assess visuospatial learning and memory. We used generalized additive, linear and zero-inflated Poisson mixed regression models to estimate associations between prenatal or postnatal Mn concentrations and repeated measures of all four VRAM outcomes: time, distance, working and reference memory errors. Effect measure modification by sex was examined in stratified models. Results U-shaped associations between prenatal Mn and VRAM outcomes were observed among girls only (pGAMM =0.001 to 0.02 in stratified models). Compared to the mid-tertile of prenatal Mn, girls in the highest tertile took 7.7 seconds [95% CI: −6.1, 21.5] longer to complete the task, traveled 2.3 maze units [0.1, 4.4] farther, and committed more working and reference memory errors (β for count ratio=1.33 [1.01, 1.83]; 1.10 [0.98, 1.24], respectively). This association was not observed among boys. In contrast, for postnatal Mn, no significant associations were found, and patterns were similar for boys and girls. Conclusions The prenatal period may be a critical window for the impact of environmental Mn on visuospatial ability and executive function, especially for females.

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Section: Introductionmentioning

confidence: 99%

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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“…82,83 Associations with Mn exposure and school age neurobehavioral outcomes point to an increase in externalizing behaviors and attention problems. 84,85 The effect of Mn on neurodevelopment may be magnified by teratogenic prenatal exposures or by neurocognitive and behavioral deficits of Mn-exposed caregivers. 82,86 The specific effects of parenteral Mn on neurologic function in infants and children are difficult to assess.…”

Section: Infants and Children: Cognition And Neurodevelopmentmentioning

confidence: 99%

Manganese and Parenteral Nutrition

Aschner¹,

Maitre²

2014

Manganese in Health and Disease

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For more than four decades, parenteral nutrition has provided life-sustaining macronutrient and micronutrient nutritional therapy for patients unable to tolerate enteral nutrition. Despite its critical importance and widespread use, the optimal dosing of various parenteral nutrition additives is unknown, posing a threat to human health. This knowledge gap is particularly acute for the trace element manganese (Mn), which is routinely added to parenteral nutrition solutions used for children and adults. Mn is an essential metal required for normal growth and development. However, excessive parenteral dietary Mn can be neurotoxic, causing a constellation of psychological and neurological symptoms known as manganism. Mn neurotoxicity is a well-described entity in adults receiving prolonged parenteral nutrition. Infants and children requiring parenteral nutrition represent an understudied and particularly vulnerable population whose susceptibility to the toxic effects of excess Mn is complicated by their developmental stage. This chapter will review the risk factors for the potential adverse effects of parenteral Mn when provided in excessive amounts, or when normal metabolism or excretion is altered by an underlying medical condition or by developmental immaturity. The need for the establishment of safe guidelines is emphasized and areas for potential research are highlighted.

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“…More recently, findings from a study conducted in Brazil examining behavior traits in school-aged children exposed to airborne manganese were published in several research articles (93)(94)(95). Investigators found that children with elevated airborne manganese levels had significantly increased inattention and externalizing behaviors (93).…”

Section: Manganesementioning

confidence: 99%

“…The CBCL has undergone several revisions over the last 30 years, its latest version assesses externalizing and internalizing behaviors based on the DSM-oriented scales as well as syndrome scales. Researchers have utilized the CBCL for studies examining behavioral problems such as ADHD and aggression (93,141,142). It has also been used to assess emotional problems such as anxiety and depression (143)(144)(145).…”

Section: Measures Of Anxiety and Depression In Childrenmentioning

confidence: 99%

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Pediatric anxiety and/or depression problems : associations with PM10, fly ash, and metal exposure.

Hagemeyer¹

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Elevated manganese exposure and school-aged children's behavior: A gender-stratified analysis

Cited by 80 publications

References 29 publications

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Manganese and Parenteral Nutrition

Pediatric anxiety and/or depression problems : associations with PM10, fly ash, and metal exposure.

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