Elevated maternal cytokine levels at birth and risk for psychosis in adult offspring

Allswede, Dana; Buka, Stephen L.; Yolken, Robert H.; Torrey, E. Fuller; Cannon, Tyrone D.

doi:10.1016/j.schres.2016.02.022

Cited by 54 publications

(39 citation statements)

References 42 publications

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“…A recent study reported that overall maternal levels of a different pro-inflammatory cytokine, TNF-α, were negatively associated with odds of offspring depression, although there was effect modification by sex when considering the ratio of TNF-α to the anti-inflammatory IL-10 (30). Consistent with the direction of our finding for IL-4, a prior study reported that elevated maternal levels of anti-inflammatory Th2 cytokines including IL-4 were associated with a reduced risk of psychosis (36). Conversely, our finding for IL-4 occurred only in the cases with BD without psychotic features.…”

Section: Discussionsupporting

confidence: 90%

Maternal serum cytokine levels and risk of bipolar disorder

Cheslack‐Postava

Cremers

Bao

et al. 2017

Brain, Behavior, and Immunity

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Prenatal exposure to influenza has previously been associated with increased risk of bipolar disorder (BD), an association that may be mediated by maternal cytokines. The objective of this study was to determine the association between maternal levels of cytokines measured during each trimester of pregnancy and the risk of BD in offspring. We conducted a case-control study nested in the Child Health and Development Study, a birth cohort that enrolled pregnant women in 1959–1966. Potential cases with DSM-IV-TR bipolar I disorder, bipolar II disorder, BD not otherwise specified, and BD with psychotic features were ascertained through electronic medical records, a public agency database, and a mailing to the cohort. Diagnoses were confirmed by clinical interview. Nine cytokines (IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-γ, TNF-α and GM-CSF) were measured simultaneously by Luminex assays in archived prenatal maternal serum samples from 85 cases and 170 matched controls. Data were analyzed using conditional logistic regression. In the overall study sample, there were no significant associations between prenatal maternal cytokine levels and BD after adjustment for confounders. The risk of BD without psychotic features was decreased among subjects with higher maternal levels of first trimester log-transformed IL-4 (OR (95% CI)=0.76 (0.58, 0.98); p=0.04) and third trimester log-transformed IL-6 (OR (95% CI)=0.64 (0.42, 0.98); p=0.04). In conclusion,higher levels of prenatal maternal cytokines were not associated with increased risk for BD. Further studies with larger samples are necessary to confirm the finding.

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Section: Discussionsupporting

confidence: 90%

Maternal serum cytokine levels and risk of bipolar disorder

Cheslack‐Postava

Cremers

Bao

et al. 2017

Brain, Behavior, and Immunity

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“…It is known that obese pregnant mothers have higher levels of C‐reactive protein and inflammatory cytokines including interleukin‐1, interleukin‐6, interleukin‐8, and tumor necrosis factor‐alpha in plasma and placentas, than pregnant mothers with normal weight . Elevated maternal C‐reactive protein and pro‐inflammatory cytokine levels during pregnancy are associated with increased risk of neurodevelopmental and psychiatric disorders in offspring . Additionally, intrauterine and placental inflammatory milieu are associated with fetal neurodevelopmental damage and altered gene expression in the neonatal brain .…”

Section: Discussionmentioning

confidence: 99%

“…[40][41][42] Elevated maternal C-reactive protein and pro-inflammatory cytokine levels during pregnancy are associated with increased risk of neurodevelopmental and psychiatric disorders in offspring. [43][44][45] Additionally, intrauterine and placental inflammatory milieu are associated with fetal neurodevelopmental damage and altered gene expression in the neonatal brain. [43][44][45] Furthermore, animal model studies showed that obesity induced by a high-fat diet during pregnancy alters fetal brain inflammatory signaling, which has downstream effects on microglial functioning, brain development, and subsequent neuropsychiatric disorders in children.…”

Section: Studymentioning

confidence: 99%

Maternal obesity and risk of cerebral palsy in children: a systematic review and meta‐analysis

Zhang

Peng

Chang

et al. 2018

Develop Med Child Neuro

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“…Th1-related cytokines include interferon gamma (IFN-γ), which affects the severity of asthma [4], and interleukin 12 (IL-12), which induces Th1 cells and suppresses Th2 cells [5,6]. Th2-related cytokines include IL-4, IL-5, IL-13, and Th17-related cytokines (tumor necrosis factor-alpha (TNF-α) IL-6, and IL-1β) [7]. IL-4 modulates IgE levels, resulting in inflammatory cell migration to inter-respiratory cells [8], and IL-13 induces morphological changes in the pulmonary system typical of asthma, such as mucous hypersecretion, epithelial hyperplasia, base membrane thickening, inflammatory cell infiltration, and B cell activation [9–12].…”

Section: Introductionmentioning

confidence: 99%

Opuntia humifusamodulates morphological changes characteristic of asthma via IL-4 and IL-13 in an asthma murine model

Lee

Bae

Choi

et al. 2017

Food & Nutrition Research

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Asthma is a chronic pulmonary disease that affects an estimated 235 million people worldwide, but asthma drugs have many adverse effects. Opuntia humifusa (eastern prickly pear) has been used as a food and traditional medicine worldwide; however, its anti-asthmatic effects have not been reported. We evaluated O. humifusa as a potential therapeutic or preventive component of anti-asthmatic drugs. We divided ovalbumin-sensitized mice into the following groups: normal control, asthma-induced control, dexamethasone-treated group (positive control), 50 mg/kg O. humifusa-treated group, 100 mg/kg O. humifusa-treated group, and 500 mg/kg O. humifusa-treated group. Levels of Th1/Th2/Th17-related cytokines were evaluated using RT-PCR, ELISA, and immunohistochemistry. O. humifusa dose-dependently suppressed the morphological changes typically observed in asthma, such as goblet cell hyperplasia, inflammatory cell infiltration, mucous hypersecretion, and relative basement membrane thickening in the respiratory system. These results may be attributable to regulation of Th1-/Th2-/Th17-related factors, especially interleukin (IL)-4 and IL-13. We conclude that O. humifusa is a potential anti-asthmatic functional food. Abbreviations: O. humifusa: Opuntia humifusa; Th: helper T; RT-PCR: real-time polymerase chain reaction; ELISA: enzyme-linked immunosorbent assay; IL: interleukin; WHO: World Health Organization; IFN-γ: interferon gamma; TNF-α: tumor necrosis factor-alpha; IgE: immunoglobulin E; CD: cluster of differentiation; OVA: ovalbumin; DEX: dexamethasone; BALF: bronchoalveolar fluid; H&E: hematoxylin and eosin; PAS: periodic acid-schiff; PBS: phosphate-buffered saline; BM: basement membrane; cDNA: complementary deoxyribonucleic acid; RNA: ribo nucleic acid; RIPA: radioimmunoprecipitation assay; IHC: immunohistochemistry; HPLC: high-performance liquid chromatography; SD: standard deviation; WBC: white blood cells; APCs: antigen-presenting cells

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Elevated maternal cytokine levels at birth and risk for psychosis in adult offspring

Cited by 54 publications

References 42 publications

Maternal serum cytokine levels and risk of bipolar disorder

Maternal serum cytokine levels and risk of bipolar disorder

Maternal obesity and risk of cerebral palsy in children: a systematic review and meta‐analysis

Opuntia humifusamodulates morphological changes characteristic of asthma via IL-4 and IL-13 in an asthma murine model

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