Elevated matrix metalloproteinase-7 expression promotes metastasis in human lung carcinoma

Han, Jichang; Li, Xiandong; Du, Jin; Xu, Feng; Wei, Yu‐Ju; Li, Hongbing; Zhang, Yijie

doi:10.1186/1477-7819-13-5

Cited by 14 publications

(8 citation statements)

References 35 publications

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“…MMP‐7 was frequently associated with LNM, while MMP‐26 was not. Previous researches associated the expression of matrilysins with LNM in other tumors, such as lung and esophageal SCC . Therefore, matrilysins seem to play an essential role in cancer spread, possibly by activating other mechanisms such as EMT .…”

Section: Discussionmentioning

confidence: 98%

“…Among others, MMP‐2 and ‐9 are the most prominent, being responsible for basement membrane breakdown; thus, their association with cancer is extensively reported in the literature . Previous systematic reviews (SR) have associated the presence of MMPs ‐7, ‐2, and ‐9 with poor disease outcomes in different types of cancers, such as breast and lung carcinoma …”

Section: Introductionmentioning

confidence: 99%

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Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta‐analysis

2019

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Background: The aim of this systematic review (SR) was to summarize and critically appraise available evidence on the association of the immunohistochemical expression of matrix metalloproteinases (MMPs) with the occurrence of lymph node/distant metastasis of oral squamous cell carcinoma (OSCC).Methods: Searches were conducted in five main electronic and three gray literature databases.Results: From 2128 records identified, 50 were included for qualitative analysis. A total of 12 MMPs were identified (--26, and MT1-MMP). Most included studies reported a positive association of MMP-1, -2, -3, -7, -9, and MT1-MMP with lymph node metastasis. MMP-8, -25, and -26 were not associated with lymph node metastasis.Conclusions: According to this SR, MMP-1, -2, -3, -7, -9, and MT1-MMP seem to play an important role in lymph node metastasis of OSCC. K E Y W O R D Simmunohistochemistry, lymphatic metastasis, matrix metalloproteinases, mouth neoplasms, neoplasm metastasis, systematic review

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta‐analysis

2019

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“…For instance, MMP-7 is linked to progression of several malignancies including oral squamous cell carcinoma, prostate cancer, pancreatic cancer, breast cancer, and non-small cell lung cancer. 25 In addition, MMP-7 is also thought to promote fibrosis by cleaving of E-cadherin and other factors such as HB-EGF which promotes lung fibroblast proliferation. 26 MMP-7 action on E-cadherin enables β-catenin signaling which is associated with increased vascular smooth muscle cell proliferation and is increased in PAH pulmonary arterial smooth muscle cells.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension

et al. 2019

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Pulmonary arterial hypertension is a severe disease for which diagnosis often is delayed. Matrix metalloproteinases have been suggested to play a role in vascular remodeling and pulmonary hypertension development. Our aim was therefore to investigate the potential role of matrix metalloproteinases as biomarkers in diagnosis and differentiation of pulmonary arterial hypertension in relation to various causes of dyspnea and pulmonary hypertension. Using proximity extension assays, 10 matrix metalloproteinases and associated proteins were analyzed in venous plasma from healthy controls (n = 20), as well as patients diagnosed with pulmonary arterial hypertension (n = 48), chronic thromboembolic pulmonary hypertension (n = 20), pulmonary hypertension due to heart failure with preserved (n = 33) or reduced (n = 36) ejection fraction, and heart failure with reduced ejection fraction and heart failure with preserved ejection fraction without pulmonary hypertension (n = 15). Plasma levels of matrix metalloproteinase-2, -7, -9, -12 and TIMP-4 were elevated (p < 0.01) in pulmonary arterial hypertension compared to controls. Plasma levels of matrix metalloproteinase-7 were furthermore lower (p < 0.0081) in pulmonary arterial hypertension than in all the other disease groups, but higher compared to controls (p < 0.0001). Receiver operating characteristic analysis of matrix metalloproteinase-7 resulted in sensitivity of 58.7% and a specificity of 83.3% for detecting pulmonary arterial hypertension among the other disease groups. Plasma matrix metalloproteinase-7 may provide a potential new diagnostic tool to differentiate pulmonary arterial hypertension from other causes of dyspnea, including heart failure with or without pulmonary hypertension and healthy controls. Matrix metalloproteinase-7 may furthermore be involved in the development of pulmonary hypertension and pulmonary arterial hypertension. Future studies investigating the clinical usefulness of matrix metalloproteinase-7 in the differentiation and earlier diagnosis of pulmonary arterial hypertension, as well as its relationship to pulmonary arterial hypertension pathogenesis, are encouraged.

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“…Upregulated MMP expression has been reported for several malignant conditions where they are involved in tumor proliferation and invasion as well as metastasis 28-32. The enzymes are located in the extracellular space and can be used for early detection and as biomarkers of disease progression and metastasis 33-35. Alternative MMP-responsive moieties are peptides that can be applied as cleavable linkages to introduce site-specific biodegradation or drug release 36-39.…”

Section: Introductionmentioning

confidence: 99%

Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model

Nagel¹,

Sousa-Hervés²,

Wedepohl³

et al. 2020

Theranostics

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Physiological barriers inside of tumor tissue often result in poor interstitial penetration and heterogeneous intratumoral distribution of nanoparticle-based drug delivery systems (DDS). Novel, matrix metalloproteinase (MMP)-sensitive peptide-crosslinked nanogels (pNGs) as multistage DDS are reported with a beneficial size reduction property to promote the process of deep tissue penetration.Methods: The presented pNGs are based on a dendritic polyglycerol (dPG) scaffold crosslinked by a modified MMP-sensitive fluorogenic peptide. The crosslinker integrates degradability in response to proteases present in the tumor microenvironment. Surfactant-free, inverse nanoprecipitation is employed to prepare the nanogels using strain-promoted click chemistry. The size and crosslinking density of the pNGs are controlled by the functionalization degree of dPG with cyclooctyne groups and by the peptide crosslinker fraction. The intrinsic reporter moiety of the crosslinker was used to study the influence of pNG compositions on the degradation profile. The therapeutic drug Doxorubicin was conjugated through a pH-sensitive linkage to dPG to form a multistage DDS. The penetration behavior of the pNGs was studied using agarose matrix and multicellular tumor spheroids (MCTS).Results: Nanogel sizes were controlled in the range of 150-650 nm with narrow size distributions and varying degrees of crosslinking. The pNGs showed stability in PBS and cell media but were readily degraded in the presence of MMP-7. The crosslinking density influenced the degradation kinetic mediated by MMP-7 or cells. Stable conjugation of DOX at physiological pH and controlled drug release at acidic pH were observed. The digestions of nanogels lead to a size reduction to polymer-drug fragments which efficiently penetrated into agarose gels. Moreover, the degradable multistage pNGs demonstrated deeper penetration into MCTS as compared to their non-degradable counterparts. Thus, degradable pNGs were able to deliver their cargo and efficiently reduce the cell viability in MCTS.Conclusion: The triggered size reduction of the pNGs by enzymatic degradation can facilitate the infiltration of the nanocarrier into dense tissue, and thereby promote the delivery of its cargo.

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Elevated matrix metalloproteinase-7 expression promotes metastasis in human lung carcinoma

Cited by 14 publications

References 35 publications

Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta‐analysis

Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta‐analysis

Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension

Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model

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