Elevated mean platelet volume predicts poor prognosis in colorectal cancer

Li, Na; Yu, Zhiwei; Zhang, Xin; Liu, Tiemin; Sun, Yanqing; Wang, Rui Tao; Yu, Kai

doi:10.1038/s41598-017-11053-y

Cited by 52 publications

(58 citation statements)

References 18 publications

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“…Many scholars have reported that MPV levels might serve as potential biomarkers for the diagnosis and early recognition of different stages of CRC . Furthermore, it was previously reported that patients with increased MPV had worse survival rates than those of patients with normal MPV levels . Additionally, one study found that the PDW levels of patients with CRC were higher than those in healthy participants but lower than those in adenomatous patients .…”

Section: Discussionmentioning

confidence: 99%

“…As independent prognostic factors, MPV, PDW, and monocytes are easily collected from routine blood tests. It has been proposed that these factors might help stratify patients with cancer into those who may or may not benefit from adjuvant chemotherapy . One study showed that systemic chemotherapy and regional chemotherapy reduced hematogenous metastasis in patients with CRC after resection, suggesting improved survival rates .…”

Section: Discussionmentioning

confidence: 99%

“…26,27 Furthermore, it was previously reported that patients with increased MPV had worse survival rates than those of patients with normal MPV levels. 28 Additionally, one study found that the PDW levels of patients with CRC were higher than those in healthy participants but lower than those in adenomatous patients. 26 That signified that PDW was an advantageous prognostic factor for the survival of patients with CRC.…”

Section: Discussionmentioning

confidence: 99%

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Nomogram for predicting overall survival in stage II‐III colorectal cancer

et al. 2020

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Purpose The overall survival (OS) of patients diagnosed with stage II‐III colorectal cancer (CRC) can vary greatly, even between patients with the same tumor stage. We aimed to design a nomogram to predict OS in resected, stage II‐III CRC and stratify patients with CRC into different risk groups. Patients and Methods Based on data from 873 patients with CRC, we used univariate Cox regression analysis to select the significant prognostic features, which were subjected to the least absolute shrinkage and selection operator (LASSO) regression algorithm for feature selection. Cross‐validation was used to confirm suitable tuning parameters (λ) for LASSO logistic regression. Then, the nomogram was used to estimate 3‐ and 5‐year OS based on the multivariable Cox regression model. The survival curves of the two groups were produced using the Kaplan‐Meier method. Risk group stratification was performed to assess the predictive capacity of the nomogram. Results Preoperative mean platelet volume, preoperative platelet distribution width, monocytes, and postoperative adjuvant chemotherapy were identified as independent prognostic factors by LASSO regression and integrated for the construction of the nomogram. The nomogram provided good discrimination, with C‐indices of 0.67 and 0.69 for the training and validation sets, respectively. Calibration plots illustrated excellent agreement between the nomogram predictions and actual observations for 3‐ and 5‐year OS. Moreover, a significant difference in OS was shown between patients stratified into different risk groups (P < .001). Conclusion We constructed and validated an original predictive nomogram for OS in patients with CRC after surgery, facilitating physicians to appraise the individual survival of postoperative patients accurately and identify high‐risk patients who need more aggressive treatment and follow‐up strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Nomogram for predicting overall survival in stage II‐III colorectal cancer

et al. 2020

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“…Cancer is frequently characterised by a hypercoagulable state and a mean platelet volume can predict poor prognosis in some cancers [90,91]. Platelets are implicated in cancer progression and metastasis by preventing intra-tumoural haemorrhage, and promoting angiogenesis and the tethering and arrest of circulating tumour cells.…”

Section: Tumour Resident Cells That Mediate Immunosuppressionmentioning

confidence: 99%

Tailoring Natural Killer cell immunotherapy to the tumour microenvironment

Barrow

Colonna

2017

Seminars in Immunology

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Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have supplanted to evade NK cell surveillance. We highlight novel strategies designed to alleviate or circumvent the immunosuppressive conditions of the tumour microenvironment in order to emancipate NK cell function and stifle the inexorable growth and metastasis of malignant cells.

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“…4 This might make this laboratory test difficult to use in routine clinical work unless the pathophysiological basis for the effect of extremes in platelet size can be established. Important questions about this effect are: We initially searched the MEDLINE database using PubMed with the MeSH term mean platelet volume to determine if there were many clinical studies with this laboratory test.…”

Section: Clinical Questionsmentioning

confidence: 99%