Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer

An, Xin; Ding, Pei Rong; Li, Yu Hong; Wang, Feng Hua; Shi, Yan; Wang, Zhi Qiang; He, Yi; Xu, Rui‐Hua; Jiang, Wen Qi

doi:10.3109/1354750x.2010.491557

Cited by 215 publications

(177 citation statements)

References 20 publications

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“…From then on, a large number of clinical studies have been performed to understand the neutrophil-cancer relationship. Clinical data have often related elevated circulating neutrophil counts or elevated neutrophil-to-lymphocyte ratios (NLRs) as a predictive parameter for poor outcome and formation of distant metastasis in patients with epithelial malignancies [367], including lung [368,170], gastric [159,163,369], renal cell carcinoma [370], ovarian [141], hepatic [143,148,371], pancreatic [138], colon cancer [145,372], and colorectal carcinoma [152] (Table 3). However, Caruso et al [200] observed that when analyzing the amount of tumor-infiltrated neutrophils in advanced gastric carcinoma, in female but not male, patients with higher TANs had a favorable prognosis.…”

Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

342

261

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Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

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Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

342

261

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“…The pretreatment NLR was found to be an independent predictor of outcome in patients treated with systemic therapies for malignant mesothelioma [21], colorectal liver metastases [22], advanced pancreatic cancer [23], ovarian cancer [24], gastric cancer [25], and renal cell carcinoma [26].…”

Section: Introductionmentioning

confidence: 99%

“…The neutrophil-to-lymphocyte ratio (NLR) is an easily measured, reproducible, and inexpensive marker of systemic inflammation [21][22][23][24] that is associated with outcome in different cancer types. The pretreatment NLR was found to be an independent predictor of outcome in patients treated with systemic therapies for malignant mesothelioma [21], colorectal liver metastases [22], advanced pancreatic cancer [23], ovarian cancer [24], gastric cancer [25], and renal cell carcinoma [26].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

et al. 2012

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Background. The neutrophil-to-lymphocyte ratio (NLR), an inflammation marker, is prognostic in several cancers. We assessed the association between the pretreatment NLR and outcome of patients with metastatic castrationresistant prostate cancer (mCRPC) treated with the CYP17 inhibitor ketoconazole.Methods. This was an international, retrospective study of 156 mCRPC patients treated with ketoconazole. The independent effect of the pretreatment NLR and factors associated with treatment outcome were determined by multivariate analysis.Results. Seventy-eight patients (50%) had a >50% decline in prostate-specific antigen (PSA). The median progression-free survival (PFS) time was 8 months. Excluded from the analysis were 23 patients without available data on their NLR and those with a recent health event or treat-

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“…The N/L ratio was calculated from the differential count by dividing the absolute neutrophil count by the absolute lymphocyte count. An N/L ratio ≥5 was considered elevated in accordance with the literature 8, 11, 17, 18…”

Section: Methodsmentioning

confidence: 81%

“…The tumor cells then produce chemokines, cytokines, and prostaglandins, which recruit inflammatory cells, which then subsequently trigger cancer‐related inflammation and further facilitate various tumor‐promoting effects 7. The neutrophil : lymphocyte (N/L) ratio has been shown to reflect the immune response and has been identified as a prognostic marker in many cancers, including gastrointestinal tract malignancy, non‐small cell lung cancer, cervical cancer, hepatocellular carcinoma, pancreatic cancer, ovarian cancer, and soft‐tissue sarcoma, reflecting a consistently decreased survival in patients with a high N/L ratio 8, 9, 10, 11, 12, 13, 14, 15. In addition, N/L ratio is reportedly correlated to incidental microcarcinoma in thyroid goiters, further indicating its potential as a diagnostic marker 16.…”

Section: Introductionmentioning

confidence: 99%

Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Nanki

Chiyoda

Kataoka

et al. 2017

J of Obstet and Gynaecol

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AimTo examine the usefulness of the neutrophil : lymphocyte (N/L) ratio as a cost‐effective and simple diagnostic marker of mature cystic teratoma (MCT) with malignant transformation (MT).MethodsA retrospective chart review was performed between 1998 and 2013 of 12 MCT patients with MT and between 2009 and 2013 of 130 patients with benign MCT. Data were collected on age, tumor size, white blood cell count with differential counts, tumor marker levels, and presenting features.ResultsOlder age, greater tumor size, higher CA19‐9 or CA125, higher neutrophil count, and higher N/L ratio were associated with MT on univariate analysis. White blood cell count; lymphocyte count; and the tumor marker squamous cell carcinoma antigen were not associated with MT. Older age (≥median), larger tumor size (≥10 cm), and high N/L ratio (≥5.0) were predictors of MT (hazard ratio, 11.51, 5.87, and 11.11, respectively). Six of 12 patients were diagnosed with MT on preoperative magnetic resonance imaging and five of 12 had an N/L ratio ≥5.0.ConclusionsNeutrophil : lymphocyte ratio is a potential preoperative diagnostic marker of MT. The optimal cut‐off should be determined in future large‐scale studies.

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Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer

Abstract: Elevated NLR is a predictor of shorter survival in patients with advanced PC.

Cited by 215 publications

References 20 publications

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

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