Elevated Parathyroid Hormone, But Not Vitamin D Deficiency, Is Associated With Increased Risk of Heart Failure in Older Men With and Without Cardiovascular Disease

Wannamethee, SG; Welsh, Paul; Papacosta, Olia; Lennon, Lucy; Whincup, Peter H.; Sattar, Naveed

doi:10.1161/circheartfailure.114.001272

Cited by 82 publications

(60 citation statements)

References 42 publications

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“…Other studies, however, are inconclusive when demonstrating that vitamin D or vitamin D carrier protein deficiency has a role in HF [98,99]. As a result, it is important to bear in mind that further studies need to be performed before drawing conclusions on the role of vitamin D in HF.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Pérez-Hernández

Aptilon-Duque

Nostroza-Hernández

et al. 2016

Korean J Intern Med

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Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.

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Section: Methodsmentioning

confidence: 99%

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Pérez-Hernández

Aptilon-Duque

Nostroza-Hernández

et al. 2016

Korean J Intern Med

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“…demonstrated in their study that elevated PTH was related with increased risk of incident heart failure in older men with and without CV disease. [28]…”

Section: Discussionmentioning

confidence: 99%

Study of vitamin D status in patients with dilated cardiomyopathy at a teaching hospital in North India

Priya

Siddiqi

Karoli

et al. 2016

J Cardiovasc Echography

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Background/Introduction:Recent studies have indicated a much broader role to Vitamin D than simply the regulation of calcium metabolism alone. Vitamin D likely confers physiologically relevant pleiotropic functions that include cardioprotective and immunomodulatory effect, and its deficiency could lead to increased risk of cardiovascular disease and heart failure.Aim:The aim of our work was to evaluate the presence of hypovitaminosis D in patients with dilated cardiomyopathy (DCMP) and to study any correlation of echocardiographic parameters with Vitamin D deficiency.Patients and Methods:In an observational case–control hospital-based study, 56 patients diagnosed to have DCMP and 60 age-, gender-, and body mass index-matched controls who were patients of other medical illnesses were included in the study. Each subject underwent transthoracic two-dimensional guided M-mode echocardiography, and Vitamin D, parathyroid hormone (PTH), and N-terminal pro-B-type natriuretic peptide (NT-ProBNP) were assessed.Results:Mean 25-hydroxyvitamin D3 [25(OH) D3] levels were significantly lower (14.5 ± 7.4 ng/ml vs. 28.2 ± 12 ng/ml, P = 0.001), whereas PTH (90.5 ± 28.5 pg/ml vs. 57 ± 20.2 pg/ml, P = 0.02) and NT-proBNP levels were significantly greater in patients with DCMP than controls. In DCMP group, 24/56 patients had severe Vitamin D deficiency, whereas in control group, 10/60 patients had severe hypovitaminosis D. There was a significant negative correlation between 25(OH) D3 concentrations and left ventricular (LV) end-diastolic and LV end-systolic dimensions.Conclusion:Patients with DCMP had lower Vitamin D levels than controls, and Vitamin D deficiency had a significant correlation with cardiac function. Therefore, screening for Vitamin D deficiency along with prompt treatment is recommended in patients with DCMP.

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“…A third possibility is that FGF23 is correlated with other causes of cardiovascular disease, most notably other mineral metabolites which may also have adverse cardiovascular effects (6, 38, 44, 51–54). In particular, higher serum phosphate is associated with increased risk of cardiovascular disease and promotes vascular calcification and dysfunction experimentally (38, 52, 54–56), whereas deficiency of the FGF23 co-receptor, klotho, may also directly induce vascular calcification and cardiac hypertrophy (44, 57).…”

Section: Translating Epidemiologic Findings and The Role Of Fgf23 In mentioning

confidence: 99%

Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease

Scialla

2015

Current Opinion in Nephrology and Hypertension

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Purpose of Review Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Animal studies have demonstrated direct and indirect effects of FGF23 that may promote heart disease. Herein we review the recent epidemiologic literature evaluating the relationship between FGF23 and cardiovascular disease. Recent Findings In observational prospective studies higher FGF23 associates with greater risk of incident cardiovascular disease including ischemic heart disease, stroke, heart failure, and atrial fibrillation. These studies establish a temporal sequence of events over long term-follow up that suggest a possible role of FGF23 in cardiovascular disease pathogenesis. In most studies risk is generally graded, however in the largest study to date, higher FGF23 within the low-normal range was not associated with higher risk. In several recent studies higher FGF23 associated more strongly with risk of congestive heart failure compared with atherosclerotic events, a finding consistent with surrogate endpoints and animal experiments. Currently the utility of FGF23 as a predictive biomarker of cardiovascular risk is not established, and interventions to reduce FGF23 need to be studied to confirm its possible pathophysiologic role. Summary Higher FGF23 is associated with the subsequent development of cardiovascular disease, and perhaps most notably heart failure, in a growing number of studies. These findings bolster ongoing efforts to lower FGF23 using strategies to reduce phosphate intake and absorption.

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Elevated Parathyroid Hormone, But Not Vitamin D Deficiency, Is Associated With Increased Risk of Heart Failure in Older Men With and Without Cardiovascular Disease

Cited by 82 publications

References 42 publications

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Study of vitamin D status in patients with dilated cardiomyopathy at a teaching hospital in North India

Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease

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