Elevated Peptide YY Levels in Adolescent Girls with Anorexia Nervosa

Misra, Madhusmita; Miller, Karen K.; Tsai, Patrika; Gallagher, Katie M.; Lin, Alvin; Lee, Noel; Herzog, David B.; Klibanski, Anne

doi:10.1210/jc.2005-1878

Cited by 227 publications

(160 citation statements)

References 35 publications

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“…Changes in PYY levels with weight gain are conflicting, with one reporting a decrease [24] and the other no change [25] in PYY levels following an increase in weight. Our group has shown that in adolescent girls with anorexia nervosa, BMI and PYY levels were inversely correlated, and a trend toward a decrease in PYY levels followed weight recovery [22]. Our data show an inverse association between BMI and PYY levels in adult women with anorexia nervosa.…”

Section: Discussionsupporting

confidence: 58%

“…Therefore mechanisms leading to bone loss are important to identify. Several previous studies have suggested that females with anorexia nervosa have elevated PYY levels relative to normal weight or obese individuals [22][23][24][25]. This is the first study to demonstrate a strong association between elevated PYY values and lower BMD in women with anorexia nervosa, suggesting a possible contribution of PYY to the severely low BMD found in this disorder.…”

Section: Introductionsupporting

confidence: 50%

“…Our data are in agreement with this hypothesis, as they demonstrate strong inverse correlations between PYY and BMD in the spine, a region with an increased proportion of trabecular bone. In addition, in a study by Misra et al, PYY was found to negatively correlate with markers of bone formation and resorption [22] supporting a role for PYY in the regulation of BMD. However, in contrast with the data regarding the effects of the Y receptor knock-out effects on bone, Wortley et al have recently reported a PYY-knock-out mice model with an osteopenic phenotype, including a reduction in trabecular bone mass and decrease in bone strength [20].…”

Section: Discussionmentioning

confidence: 88%

“…Most previous studies have reported elevated PYY levels in subjects with anorexia nervosa relative to normal weight individuals [22,24,25]. Changes in PYY levels with weight gain are conflicting, with one reporting a decrease [24] and the other no change [25] in PYY levels following an increase in weight.…”

Section: Discussionmentioning

confidence: 97%

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Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa

Utz¹,

Lawson²,

Misra³

et al. 2008

Bone

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105

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Introduction-Anorexia nervosa is a psychiatric illness that results in significant bone loss. Studies examining the neuroendocrine dysregulation that occurs in AN may increase understanding of endocrine systems that regulate bone mass. PYY is an anorexigenic peptide derived primarily from the intestine, with actions mediated via activation of Y-receptors. We have previously shown that PYY levels are elevated in adolescents with AN. Y2 receptor knockout mice have increased bone mineral density (BMD) and thus PYY may play a role in regulating bone mass. We hypothesized that PYY levels would be inversely associated with BMD in women with AN.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa

Utz¹,

Lawson²,

Misra³

et al. 2008

Bone

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105

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“…In contrast to OB subjects, increased fasting and meal-stimulated PYY levels are present in patients with anorexia nervosa (AN), suggesting that the peptide may play a physiopathological role in this eating disorder (34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity

Rigamonti

Cella

Bonomo

et al. 2011

European Journal of Endocrinology

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Objective: Changes in many gastrointestinal peptides, including the anorexigenic peptide YY (PYY), which is produced by L cells, occur in both anorexia nervosa (AN) and obesity (OB). High PYY levels are present in AN, whereas in morbid OB fasting and postprandial PYY secretion is blunted. Somatostatin (somatotropin release-inhibiting factor (SRIF)) reportedly inhibits plasma PYY concentrations in animals and healthy humans, but the effect of a SRIF infusion on spontaneous PYY secretion in AN and OB is unknown. Methods: A total of 18 young women, seven with acute AN (A-AN), four with AN in the recovery phase (R-AN), and seven with morbid OB, were studied. All subjects underwent an infusion of SRIF (9 mg/kg i.v./h, over 60 min), with blood samples drawn before and at different time intervals after SRIF administration. Plasma PYY levels were measured at each time point. Results: SRIF significantly inhibited plasma PYY concentrations in R-AN and OB, without affecting PYY titers in A-AN. In OB, the inhibitory effect of SRIF also persisted at 90 min. Withdrawal of SRIF infusion in R-AN resulted in a prompt restoration of basal plasma PYY levels, whereas termination of SRIF infusion in OB was followed by a slower increase of PYY titers toward baseline levels. After infusion, PYY D area under the curve (DAUC) in R-AN was significantly higher than those in A-AN and OB patients. A significant difference in PYY DAUC between A-AN and OB was present. Conclusions: These results suggest the existence of a hypo-and hyper-sensitivity of L cells to the inhibitory effect of SRIF in A-AN and OB respectively.

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State of the art systematic review of bone disease in anorexia nervosa

Misra

Golden

Katzman

2015

Intl J Eating Disorders

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103

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Objective Low bone mineral density (BMD) is a known consequence of anorexia nervosa (AN) and is particularly concerning during adolescence, a critical time for bone accrual. A comprehensive synthesis of available data regarding impaired bone health, its determinants, and associated management strategies in AN is currently lacking. This systematic review aims to synthesize information from key physiologic and prospective studies and trials, and provide a thorough understanding of impaired bone health in AN and its management. Method Search terms included “anorexia nervosa” AND “bone density” for the period 1995–2015, limited to articles in English. Papers were screened manually based on journal impact factor, sample size, age of participants, and inclusion of a control group. When necessary, we included seminal papers published before 1995. Results AN leads to low BMD, impaired bone quality and increased fracture risk. Important determinants are low lean mass, hypogonadism, IGF-1 deficiency, and alterations in other hormones that impact bone health. Weight gain and menses restoration are critical for improving bone outcomes in AN. Physiologic estrogen replacement as the transdermal patch was shown to increase bone accrual in one study in adolescent females with AN; however, residual deficits persist. Bisphosphonates are potentially useful in adults with AN. Discussion To date, evidence suggests that the safest and most effective strategy to improve bone health in AN is normalization of weight with restoration of menses. Pharmacotherapies that show promise include physiologic estradiol replacement (as the transdermal estradiol patch), and in adults, bisphosphonates. Further studies are necessary to determine the best strategies to normalize BMD in AN.

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Elevated Peptide YY Levels in Adolescent Girls with Anorexia Nervosa

Abstract: Elevated PYY may contribute to reduced intake and decreased bone turnover in AN.

Cited by 227 publications

References 35 publications

Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa

Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa

Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity

State of the art systematic review of bone disease in anorexia nervosa

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