Elevated percentage of CD3+T cells and pregnancy outcome in women with recurrent pregnancy loss

Du, Mengyang; Yu, Na; Ding, Qiuhong; Chen, Xiaoyue; Frempong, Sophia Twum; Cai, Xiaoyan; Bao, Shenghua

doi:10.1016/j.cca.2018.08.024

Cited by 10 publications

(14 citation statements)

References 35 publications

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“…No elevation was found in the level of CD3+ cells, except in pregnant women with URM compared with healthy pregnant participants. Such elevations in CD3+ T cells have previously been reported [ 26 ].…”

Section: Discussionsupporting

confidence: 74%

Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage

Khalaf

Mahmoud

Elkhatib

et al. 2021

Heliyon

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Section: Discussionsupporting

confidence: 74%

Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage

Khalaf

Mahmoud

Elkhatib

et al. 2021

Heliyon

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“…The body's cellular immune function status is mainly reflected by CD3+, CD4+, and CD8+ in the T cell subsets. CD3+ is an important molecular marker of T lymphocytes, which can not only regulate the balance of immune function but also directly resist antigens to exert cellular immune function effector cells, and the ratio of CD4+/CD8+ is positively correlated with the immune function of the body [ 27 , 28 ]. It can be seen that the PT, APTT, FIB, CD3+, CD4+, and CD4+/CD8+ levels of the two groups were significantly improved according to the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Etimicin Sulfate Combined with Cefotaxime Sodium in the Treatment of Patients with Septic Shock and Effect on Serum Inflammatory Factor Levels and Immune Function

Pang

Song

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effect of etimicin sulfate combined with cefotaxime sodium and cefotaxime sodium alone in the treatment of patients with septic shock and the effect on serum inflammatory factor levels and immune function. Methods. Total of 95 patients with septic shock who were treated in our hospital from March 2018 to July 2020 were collected as the subjects of this study. Among them, 44 patients who received cefotaxime sodium treatment and were included in the control group, and 51 patients who received etimicin sulfate combined with cefotaxime sodium treatment were included in the research group. The levels of serum IL-6 (interleukin-6), PCT (procalcitonin), TNF-α (tumor necrosis factor-α), CD3+ (cluster of differentiation 3+), CD4+, CD4+/CD8+, FIB (fibrinogen), and PT (prothrombin time), APTT (activated partial thromboplastin time) time before and after treatment, and the treatment effects, mechanical ventilation time, hospitalization time, and incidence of adverse reactions between the two groups were compared. Results. The total effective rate of treatment in the research group (90.20%) was higher than the control group (72.73%) ( p < 0.05 ). After treatment, the serum levels of IL-6, PCT, and TNF-α, FIB, CD3+, CD4+, CD4+/CD8+, and PT and APTT time in the two groups of patients have improved significantly ( p < 0.05 ). Compared with the control group, the research group’s IL-6, PCT, TNF-α levels, PT, and APTT decreased more, and FIB, CD3+, CD4+, and CD4+/CD8+ levels increased more ( p < 0.05 ). The mechanical ventilation time and hospital stay of the research group were significantly shorter than the control group ( p < 0.05 ). There was no significant difference between the total incidence of adverse reactions in the research group (15.69%) and the control group (9.09%) ( p > 0.05 ). Conclusion. Compared with cefotaxime sodium alone, the treatment of etimicin sulfate combined with cefotaxime sodium is more effective in improving the coagulation function and cellular immune function of patients with septic shock, reducing the level of serum inflammatory factors, and having higher clinical treatment effective.

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“…We further found significant differences in immunological adaptation to pregnancy between WT and Qa-2 - animals. In pregnant Qa-2 - mice but not in pregnant WT mice we found an increase in splenic T-cells in comparison to non-pregnant controls – an effect that may be associated with pregnancy loss ( 62 ). Analysis of T-cell subpopulations showed differences in numbers of effector memory T-cells, T regs and Th17 cells between pregnant WT and Qa-2 - animals.…”

Section: Discussionmentioning

confidence: 57%

Human Leucocyte Antigen G and Murine Qa-2 Are Critical for Myeloid Derived Suppressor Cell Expansion and Activation and for Successful Pregnancy Outcome

et al. 2022

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During pregnancy, maternal immune system has to balance tightly between protection against pathogens and tolerance towards a semi-allogeneic organism. Dysfunction of this immune adaptation can lead to severe complications such as pregnancy loss, preeclampsia or fetal growth restriction. In the present study we analyzed the impact of the murine MHC class Ib molecule Qa-2 on pregnancy outcome in vivo. We demonstrate that lack of Qa-2 led to intrauterine growth restriction and increased abortion rates especially in late pregnancy accompanied by a disturbed trophoblast invasion and altered spiral artery remodeling as well as protein aggregation in trophoblast cells indicating a preeclampsia-like phenotype. Furthermore, lack of Qa-2 caused imbalanced immunological adaptation to pregnancy with altered immune cell and especially T-cell homeostasis, reduced Treg numbers and decreased accumulation and functional activation of myeloid-derived suppressor cells. Lastly, we show that application of sHLA-G reduced abortion rates in Qa-2 deficient mice by inducing MDSC. Our results highlight the importance of an interaction between HLA-G and MDSC for pregnancy success and the therapeutic potential of HLA-G for treatment of immunological pregnancy complications.

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Elevated percentage of CD3+T cells and pregnancy outcome in women with recurrent pregnancy loss

Cited by 10 publications

References 35 publications

Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage

Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage

Efficacy of Etimicin Sulfate Combined with Cefotaxime Sodium in the Treatment of Patients with Septic Shock and Effect on Serum Inflammatory Factor Levels and Immune Function

Human Leucocyte Antigen G and Murine Qa-2 Are Critical for Myeloid Derived Suppressor Cell Expansion and Activation and for Successful Pregnancy Outcome

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