Elevated Plasma Big Endothelin-1 at Admission Is Associated With Poor Short-Term Outcomes in Patients With Acute Decompensated Heart Failure

Mo, Ran; Yang, Yanmin; Yu, Litian; Tan, Huiqiong; Zhu, Jun

doi:10.3389/fcvm.2021.629268

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…Heart failure, atrial fibrillation, and ischemia/reperfusion injury are typical lesions of endocardial endothelium. These kinds of patients may have systemic endothelial dysfunction, which combines the dysfunction of endocardium and vascular endothelium and leads to the increase of hemodynamic load of the left atrium and the increase of synthesis and release of ET-1 and angiotensin II [ 18 , 19 ]. In this study, the expression level of serum ET-1 in sepsis patients complicated with heart failure was significantly higher.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Serum CXCL8 and ET-1 Expression Levels and Sepsis Complicated with Heart Failure

Zhu

Song

Cai

et al. 2022

Cardiology Research and Practice

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Objective. The objective is to investigate the relationship between sepsis complicated with heart failure and the expression levels of CXC chemokine ligand 8 (CXCL8) and endothelin-1 (ET-1). Methods. A total of 128 sepsis patients accepted by the Ganzhou People’s Hospital from March 2019 to December 2021 were collected as observation objects, and they were separated into a simple sepsis group (86 cases) and a complicated heart failure group (42 cases) according to whether they were accompanied by heart failure or not. General data such as Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation II (APACHE II) were collected; the expression levels of serum CXCL8 and ET-1 were detected by enzyme-linked immunosorbent assay (ELISA); the cardiac function parameters such as left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) were measured by color Doppler ultrasound; the correlation between serum CXCL8 and ET-1 expression levels with clinical data and cardiac function parameters in patients with sepsis complicated with heart failure was analyzed by the Pearson correlation; and the influencing factors of sepsis complicated with heart failure were analyzed by the logistic regression analysis. Results. The serum CXCL8 and ET-1 expression levels, SOFA score, and APACHE II score in the complicated heart failure group were higher than those in the simple sepsis group ( P < 0.05 ), and LVEF, SV, CO, and CI in the complicated heart failure group were lower than those in the simple sepsis group ( P < 0.05 ). Serum CXCL8 was positively correlated with ET-1 in patients with sepsis complicated with heart failure (r = 0.531, P < 0.05 ), and the two were positively correlated with SOFA score and APACHE II score ( P < 0.05 ) and were negatively correlated with LVEF, SV, CO, and CI ( P < 0.05 ). CXCL8 and ET-1 were independent risk factors for sepsis complicated with heart failure ( P < 0.05 ). Conclusion. The expression levels of serum CXCL8 and ET-1 in sepsis patients with heart failure are significantly increased, and both are risk factors for heart failure in sepsis patients.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Serum CXCL8 and ET-1 Expression Levels and Sepsis Complicated with Heart Failure

Zhu

Song

Cai

et al. 2022

Cardiology Research and Practice

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“…In contrast to the concentrations of ET-1, which were significantly higher in patients with HTN, the concentrations of the precursor Big ET-1 did not differ significantly from those of controls ( Figure 2 ). Probably, elevated levels of Big ET-1 in patients with HTN can be detected when there is either concomitant heart failure [ 34 , 35 ], pulmonary HTN [ 36 , 37 ], coronary artery disease [ 38 , 39 ], or in combination. Interestingly, Big ET-1 and ET-1 levels were high in patients with arsenic (As)-induced HTN, which is thought to be mediated by oxidative stress as a result of chronic As exposure [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension

Kostov

Blazhev

2021

Pathophysiology

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The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding. Based on these controversial data, we tested serum levels of ET-1 and Big ET-1 (the precursor of ET-1) in patients with essential HTN, comparing the results with those of healthy normotensive controls. The levels of ET-1 and Big ET-1 were measured by ELISA. Our results in patients with essential HTN showed that the mean levels of ET-1 (5.01 ± 2.1 pg/mL) were significantly higher (F = 6.34, p = 0.0144) than the mean levels in the control group (3.2 ± 1.0 pg/mL). The levels of Big ET-1 in patients with essential HTN (0.377 ± 0.1 pmol/L) were similar to those in the control group (0.378 ± 0.07 pmol/L) and did not differ significantly (F = 0.00, p = 0.9531). These data suggest that ET-1, but not Big ET-1, may play an important role in the pathogenesis of primary HTN.

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“…Similar to other cardiovascular conditions, ET-1 levels are elevated in the blood samples of chronic HF patients of various etiologies, including diabetic cardiomyopathy and hypertrophic cardiomyopathy [200,201]. One study related natriuresis, fluid congestion, and poor clinical prognosis to the elevation of plasma ET-1 levels, while another indicated that a higher ET-1 plasma level at admission is a prognostic marker for poor short-term prognosis in acute heart failure (HF) [202,203]. Chronic HF due to ischemic heart disease has also been correlated clinically with ET-1.…”

Section: Clinical Evidence Of Endothelin In Chronic and Acute Heart F...mentioning

confidence: 99%

Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going

Haryono

Ramadhiani

Ryanto

et al. 2022

Biology

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Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous preclinical and clinical studies. Over the years, the endothelin system has been found to be critical in the pathogenesis of several cardiovascular diseases, including hypertension, pulmonary arterial hypertension, heart failure, and coronary artery disease. In this review, we summarize the current knowledge on endothelin and its role in cardiovascular diseases. Furthermore, we discuss how endothelin-targeting therapies, such as endothelin receptor antagonists, have been employed to treat cardiovascular diseases with varying degrees of success. Lastly, we provide a glimpse of what could be in store for endothelin-targeting treatment options for cardiovascular diseases in the future.

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Elevated Plasma Big Endothelin-1 at Admission Is Associated With Poor Short-Term Outcomes in Patients With Acute Decompensated Heart Failure

Cited by 11 publications

References 29 publications

The Relationship between Serum CXCL8 and ET-1 Expression Levels and Sepsis Complicated with Heart Failure

The Relationship between Serum CXCL8 and ET-1 Expression Levels and Sepsis Complicated with Heart Failure

Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension

Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going

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