Elevated Plasma Brain Natriuretic Peptide Levels Independent of Heart Disease in Acute Ischemic Stroke: Correlation with Stroke Severity

Tomita, Hirofumi; Metoki, Norifumi; Saitoh, Genta; Ashitate, Toshihiro; Echizen, Takashi; Katoh, Chisato; Fukuda, Michitaka; Yasujima, Minoru; Osanai, Tomohiro; Okumura, Ken

doi:10.1291/hypres.31.1695

Cited by 44 publications

(37 citation statements)

References 31 publications

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“…35 Increased levels of natriuretic peptides were observed in patients after stroke parallel to stroke severity as indicated by the National Institutes of Health Stroke Scale and infarct volume. 36 Hypothalamic damage results in deafferentiation of the vegetative system from central nervous system inhibitory sympathetic control and in dysregulation of the hypothalamus-pituitary-adrenal axis. 33,37 Such dysregulation occurs at both levels, the central suppressive feedback and the stimulatory feed-forward of cortisol.…”

Section: Sympathetic and Neuroendocrine Activation After Strokementioning

confidence: 99%

Body Weight After Stroke

Scherbakov

Dirnagl

Doehner

2011

Stroke

129

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Background and Purpose-Outcome after acute stroke is determined to a large extent by poststroke complications. Nutritional status and metabolic balance may substantially contribute to outcome after stroke. Key mechanisms of stroke pathophysiology can induce systemic catabolic imbalance with impaired metabolic efficiency and degradation of body tissues. Summary-Tissue wasting, sarcopenia, and cachexia may impair and delay poststroke rehabilitation and worsen the prognosis. Although current guidelines for secondary prevention after stroke recommend weight reduction, increasing evidence suggests that patients who are overweight and mildly obese may actually have a better outcome. An "obesity paradox" has been identified to describe the contrasting impact of being overweight in patients with chronic illness compared with healthy populations. We present an overview on the metabolic regulation in patients with stroke and evaluate current data on the impact of body weight and weight change after stroke. The emerging picture suggests that being overweight and obese may impact patients with stroke differently than it does healthy subjects. Conclusions-We propose that current knowledge on obesity and its management in primary prevention cannot be transferred to patients with established stroke. Systematic studies on changes in body composition after stroke and on treatment options are warranted to establish the pathophysiology and evidence-driven management of nutritional status in these patients. (Stroke. 2011;42:3646-3650.)

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Section: Sympathetic and Neuroendocrine Activation After Strokementioning

confidence: 99%

Body Weight After Stroke

Scherbakov

Dirnagl

Doehner

2011

Stroke

129

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“…Recently, we have shown that the plasma level of BNP is transiently increased in acute ischemic stroke patients with large artery atherosclerosis independently of heart disease (Tomita et al 2008), suggesting that BNP may be derived from the ischemic brain. During evolution, neurons have lost many essential metabolic pathways and gained the specialized ability to generate action potentials and communicate by synaptic transmission.…”

Section: Effect Of Hypoxia On Bnp Expression and Release In Human Astmentioning

confidence: 99%

“…The plasma level of N-terminal pro-brain natriuretic peptide is also elevated in acute ischemic stroke patients (Iltumur et al 2006), and left atrium or appendage abnormality is associated with BNP levels. More recently, we have shown that the plasma level of BNP is transiently increased in acute ischemic stroke patients with large artery atherosclerosis and reflects infarct volume and the severity of acute ischemic stroke (Tomita et al 2008). However, this was independent of heart disease and the origin and role of BNP still remain unclear.…”

Section: Introductionmentioning

confidence: 98%

Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia: a possible role in anti-apoptosis

Katoh¹,

Osanai²,

Tomita³

et al. 2010

Journal of Endocrinology

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We have recently shown that the plasma brain-type natriuretic peptide (BNP) level is elevated in acute ischemic stroke patients, but the origin and role of BNP remain unclear. We investigated whether human astrocytes secrete BNP under hypoxia, and if so, what signaling pathway is involved, and what is the role of BNP. Human astrocytoma cell line U373MG was exposed to hypoxia by Anaeropack. BNP gene expression was increased by 3 . 9G2 . 5-and 6 . 5G2 . 9-fold at 12 and 24 h after hypoxia respectively (nZ6, both P!0 . 05) and was associated with twofold increase in BNP protein at 24 h. BNP release in the culture media (pg/mg protein) was elevated from 1 . 8G1 . 8 under normoxia to 13 . 5G7 . 8 after 24-h hypoxia (nZ9, P!0 . 01 versus normoxia). Western blot revealed the tyrosine 415 phosphorylation of tyrosine kinase c-Src under hypoxia. Treatment of the cells with tyrosine kinase inhibitor PP1 abolished hypoxia-induced increase in BNP expression and release. In the cells exposed to hypoxia, caspase activity and apoptosis, measured by annexin-V-propidium iodide kit, were increased at 24 h compared with the cells under normoxia (nZ5, both P!0 . 05). It was further increased in the cells transfected with siRNA for natriuretic peptide precursor B (nZ6, both P!0 . 05) and reversed by administration of exogenous BNP (P!0 . 01).In conclusion, hypoxia increased BNP expression and release in human astrocytoma cell line U373MG through c-Src activation. BNP may play a pivotal role in anti-apoptosis of astrocytes under hypoxia.

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“…Research has shown that during the acute stroke phase, patients had an elevation of BNP and NT proBNP as well. Moreover, a significant correlation of this indicator has been noted with ischemic area during stroke, as well as with the NIHSS scale [16,32].…”

Section: Impact On Final Aschemic Cerebral Damagementioning

confidence: 99%

Prospective of ischemic stroke biomarkers

Szewczak

Nieśpiałowska

Jakubowska-Solarska

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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Methods currently used in brain vascular disorder diagnostics are neither fast enough nor clear-out; thus, there exists a necessity of finding new types of testing which could enlarge and complete the actual panel of diagnostics or be an alternative to current methods. The discovery of sensitive and specific biomarkers of ischemic brain stroke will improve the effects of treatment and will help to assess the progress or complications of the disease. The relevant diagnosis of ischemic stroke (IS) within the first 4.5 hours after the initial symptoms allows for the initiation of treatment with recombinant tissue plasminogen activators which limits the magnitude of negative changes in the brain and which enhance the final effectiveness of therapy. The potential biomarkers which are under investigation are substances involved in the processes of coagulation and fibrinolysis, and are of molecules released from damaged vascular endothelial cells and from nerves and cardiac tissue. The analyzed substances are typical of oxidative stress, apoptosis, excitotoxicity and damage of the blood brain barrier.

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Elevated Plasma Brain Natriuretic Peptide Levels Independent of Heart Disease in Acute Ischemic Stroke: Correlation with Stroke Severity

Cited by 44 publications

References 31 publications

Body Weight After Stroke

Body Weight After Stroke

Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia: a possible role in anti-apoptosis

Prospective of ischemic stroke biomarkers

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