Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel

Abstract

Elevated plasma fibrinogen (> or =375 mg/dl) in the presence of diabetes mellitus and increased BMI (> or =25 kg/m(2)) are associated with lower PI with clopidogrel in patients with CVD.

Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke

“…However, the relationship between hypertension and the incidence of clopidogrel resistance remains unclear. Although diabetes mellitus was previously suggested to influence the antiplatelet effects of clopidogrel [39,40] , we did not observe any correlation between CR and diabetes mellitus in our study population. In addition, sex, age, smoking, drinking or other biomedical indexes were not associated with CR in ischemic stroke patients.…”

Dielectric properties of human diabetic blood: Thermodynamic characterization and new prospective for alternative diagnostic techniques

“…Platelet membrane proteins can be glycated. The increased binding of fibrinogen and the increased platelet aggregation observed in diabetic patients 26 can be related to glycation of the adenosine diphosphate receptors and lipids indicating that the number of Fig. 1.…”

Effects of Endothelial Dysfunction on Residual Platelet Aggregability After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease

“…These include CYP2C19 singlenucleotide polymorphisms, age, body mass index, diabetes mellitus, renal function, C-reactive protein, fibrinogen, and endothelial function. 18,[21][22][23][24][25][26] In this study, we simultaneously measured peripheral endothelial function by RHI and evaluated RPR in a population lacking CYP2C19*2 or *3 loss-offunction allele, selected specifically to avoid the effects of this gene on platelet activity. The results identified peripheral endothelial dysfunction as a significant determinant of high RPR in patients with stable CAD.…”

“…The multivariable linear regression model consisted of RHI and the variables (age, diabetes mellitus, estimated glomerular filtration rate, and Log 10 [BNP]) that had been independently shown to impact RPR in the previous studies. 18,[21][22][23][24][25][26] Each of RHI and BNP was shown as the independently associated factor for RPR (Table 2). We also analyzed the association in the 2 groups regarding the duration of clopidogrel treatment: the short-term loading group (≤7 days) and the long-term group (>7 days).…”