Elevated plasma interleukin-6 levels in patients with acute myocardial infarction

Miyao, Yuji; Yasue, Hirofumi; Ogawa, Hisao; Misumi, Ikuo; Masuda, Tetsuro; Sakamoto, Tomohiro; Morita, Eugene Hayato

doi:10.1016/0002-8703(93)90526-f

Cited by 179 publications

(75 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 PAF is a potent mediator of several types of inflammation and is produced by a wide variety of cells with target cells in many organs. 8 Recent studies in a prolonged ischemia/reperfusion model demonstrated that PAF antagonists reduce both myocardial infarct size and the incidence of ischemia-induced arrhythmia.…”

Section: Platelet Activating Factormentioning

confidence: 99%

“…The immunoglobulin-type adhesion molecules are particularly important for the subsequent firm attachment and transendothelial migration into the surrounding tissue. 22,23 The accumulation of leukocytes plays a key role in ischemic myocardial damage through microvascular obstruction and release of deleterious substances such as inflammatory cytokines, 5,24 oxygen free radicals 7 and PAF. 8 …”

Section: Time-course and Role Of Adhesion Moleculesmentioning

confidence: 99%

See 1 more Smart Citation

Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction

et al. 1999

Self Cite

View full text Add to dashboard Cite

he most important cause of acute myocardial infarction (AMI) is plaque rupture in the coronary arteries with subsequent thrombosis. The risk of plaque rupture appears to be related to the composition of the atherosclerotic plaque. The same population of bloodderived monocytes/macrophages that transforms the atherosclerotic lesions into foam cells interacts with T lymphocytes and smooth muscle cells via growth factors and cytokines. 1 At the site of plaque rupture or erosion, inflammation processes play a role in destabilizing the fibrous cap tissue, thus enhancing the risk of coronary thrombosis. 2 However, the precise mechanisms causing plaque rupture are not fully understood. A large body of evidence points to the involvement of an inflammatory response in the pathophysiology of myocardial ischemia-reperfusion injury. 3 Leukocyte accumulation in the myocardium may amplify tissue damage by activating cardiomyocytes and by releasing deleterious substances such as inflammatory cytokines, 4,5 thromboxane A2, 6 oxygen-free radicals 7 and platelet activating factor (PAF). 8 Leukocytes and endothelium express adhesion molecules when stimulated, for example by cytokines, and their expression is considered to play a pivotal role in the localization and development of an inflammatory reaction. E-selectin as a selectin-type adhesion molecule, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) are immunoglobulin-type adhesion molecules, which are located on the surface of activated endothelial cells and bind leukocytes. Previous animal studies have clearly demonstrated that PAF antagonists, 9 and inhibition of ICAM-1 10,11 and selectin-type adhesion molecules 12 using monoclonal antibodies, significantly reduce the degree of myocardial injury that results from coronary artery occlusion and reperfusion. The aim of this study was to characterize these soluble adhesion molecules, PAF and interleukin-6 as inflammatory cytokines in patients with AMI in order to examine the possible role of these factors in the pathophysiology of AMI. Methods Study PatientsThe blood PAF levels were measured in 8 consecutive patients with AMI who were admitted within 12 h of the onset of symptoms and in 98 normal volunteers (Control). The study patients with AMI consisted of 6 men and 2 women, ranging in age from 47 to 79 years, with a mean age of 62.2±10.4 (mean ± SD) years (Study 1). We also measured the plasma levels of interleukin-6, soluble Eselectin (sE-selectin), soluble ICAM-1 (sICAM-1) and soluble VCAM-1 (sVCAM-1) in 30 patients with AMI who were admitted within 12 h of the onset of symptoms and in 15 patients with stable effort angina (SEA). The patients with AMI consisted of 26 men and 4 women, ranging in age from 30 to 80 years, with a mean age of Jpn Circ J 1999; 63: 362 -366 (Received August 31, 1998; revised manuscript received January 29, 1999; accepted February 5, 1999 Although acute myocardial infarction (AMI) may involve both plaque rupture and ischemia-reperfusion injury, the pathogenes...

show abstract

Section: Platelet Activating Factormentioning

confidence: 99%

Section: Time-course and Role Of Adhesion Moleculesmentioning

confidence: 99%

Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction

et al. 1999

Self Cite

View full text Add to dashboard Cite

show abstract

“…The plasma levels of MCSF, IL-6, and C-reactive protein (CRP) have been found elevated in patients with unstable angina 20 -22 and acute myocardial infarction [22][23][24] but have not been carefully investigated in patients with chronic stable angina. We hypothesized that MCSF, IL-1b, and IL-6 plasma levels in patients with chronic stable coronary artery disease might be associated with the anatomic extent of disease and that aspirin administration might reduce cytokine plasma levels.…”

mentioning

confidence: 99%

Increased Proinflammatory Cytokines in Patients With Chronic Stable Angina and Their Reduction By Aspirin

et al. 1999

View full text Add to dashboard Cite

Background —Proinflammatory cytokines released by injured endothelium facilitate interaction of endothelial cells with circulating leukocytes and thus may contribute to development and progression of atherosclerosis. We investigated whether cytokines and C-reactive protein (CRP) are indicative of myocardial ischemia or of diseased vessels and whether they are influenced by aspirin treatment in patients with chronic stable angina. Methods and Results —Plasma macrophage colony stimulating factor (MCSF), IL-1b, IL-6, and CRP were measured in 60 stable patients after 48-hour Holter monitoring and in 24 matched controls. All patients had angiographic documentation of disease and positive exercise ECGs. Patients with ischemia on Holter monitoring (n=40) received aspirin or placebo in a 6-week, randomized, double blind, crossover trial. Blood sampling was repeated at the end of each treatment phase (3 weeks). Compared to controls, patients had more than twice median MCSF (800 versus 372 pg/mL), IL-6 (3.9 versus 1.7 pg/mL), and CRP (1.25 versus 0.23 mg/L) levels ( P <0.01 for all comparisons). MCSF was related to ischemia on Holter monitoring ( P <0.01), to low ischemic threshold during exercise ( P <0.01), and together with IL-1b to number of diseased vessels ( P <0.05). MCSF, IL-6, and CRP were all reduced after 6 weeks of aspirin treatment ( P <0.05). Conclusions —These findings suggest that cytokines are associated with both ischemia and anatomic extent of disease in patients with stable angina. Reduced cytokine and CRP levels by aspirin may explain part of aspirin’s therapeutic action.

show abstract

“…36 Elevated levels of C-reactive protein (CRP) predict coronary events in population studies and in individuals with angina, [37][38][39] and elevated levels of TNF-␣ and of IL-6 are correlated with worse outcomes. [40][41][42] Recent studies have shown a significant increase in inflammatory markers in association with both atherosclerotic disease and the insulin-resistance syndrome. 43,44 Inflammatory-and cytokine-mediated mechanisms that contribute to insulin resistance and development of features of the metabolic syndrome are of particular interest in individuals who have undergone an allogeneic HCT because the immunologic effects of these proinflammatory cytokines are mediators of the development and progression of both acute and chronic GVHD.…”

Section: Discussionmentioning

confidence: 99%

Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study

Baker

Ness

Steinberger

et al. 2006

Blood

314

View full text Add to dashboard Cite

Elevated plasma interleukin-6 levels in patients with acute myocardial infarction

Cited by 179 publications

References 22 publications

Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction

Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction

Increased Proinflammatory Cytokines in Patients With Chronic Stable Angina and Their Reduction By Aspirin

Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study

Contact Info

Product

Resources

About