Elevated plasma levels of hepatocyte growth factor in rats experimentally envenomated with Bothrops jararaca venom: Role of snake venom metalloproteases

Prezoto, B.C.; Kato, Ellen Emi; Gonçalves, L.R.C.; Sampaio, Sandra Coccuzzo; Sano-Martins, Ida Sigueko

doi:10.1016/j.toxicon.2019.03.003

Cited by 7 publications

(4 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a significant activation of the hepatocyte growth factor (HGF)/c-met pathway in rats experimentally envenomated with B. jararaca venom was reported [119]. Active HGF production is enhanced in response to infectious challenges, but the increase in endogenous HGF levels is transient and insufficient.…”

Section: Early Diagnosis and Managementmentioning

confidence: 99%

Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review

Albuquerque

Paiva

Martins

et al. 2020

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

Bothrops are one of the most common medically important snakes found in Latin America. Its venom is predominantly hemotoxic and proteolytic, which means that local lesion (edema and redness) and hemorrhagic symptoms are recurrent in envenoming by this snake. Although hemorrhage is usually the major cause of death, snakebite-related acute kidney injury is another potentially fatal clinical complication that may lead to chronic kidney disease. The present review highlights the main studies on Bothrops venom-related acute kidney injury, including observational, cross-sectional, case-control and cohort human studies available up to December 2019. The following descriptors were used according to Medical Subject Headings (MeSH): on Medline/Pubmed and Google Scholar "acute kidney injury" or "kidney disease" and "Bothrops"; on Lilacs and SciELO "kidney disease" or "acute kidney injury" and "Bothrops". Newcastle-Ottawa quality assessment scale was used to appraise the quality of the cross-sectional and cohort studies included. The selection of more severe patients who looked for health care units and tertiary centers is a risk of bias. Due to the methodological heterogeneity of the studies, a critical analysis of the results was performed based on the hypothesis that the design of the included studies influences the incidence of acute kidney injury. Fifteen human studies (total participants 4624) were included according to stablished criteria. The coagulation abnormalities (hemorrhagic symptoms, abnormal fibrinogen and activated partial thromboplastin time) were associated with acute kidney injury in

show abstract

Section: Early Diagnosis and Managementmentioning

confidence: 99%

Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review

Albuquerque

Paiva

Martins

et al. 2020

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

show abstract

“…Indeed, several drugs based on peptide toxins, including captopril (hypertension), ziconotide (chronic pain), eptifibatide (cardiovascular diseases), lepirudin (thrombosis, stroke) and cobratoxin (pain), are currently in clinical use [ 42 ]. Venoms can contain peptides that stimulate the production of hormones and growth factors, as illustrated by the venom from the snake Bothrops jararaca [ 43 ]. This venom contains prothrombin and factor X activators that can elicit the generation of hepatocyte growth factor/scatter factor (HGF/SF), a regenerative growth factor that is considered a therapeutic target in T2D [ 44 ].…”

Section: Peptides and Substances Stimulating Insulin Secretionmentioning

confidence: 99%

Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?

Lodato¹,

Plaisance²,

Pawlowski³

et al. 2023

Cells

View full text Add to dashboard Cite

Improvement of insulin secretion by pancreatic β-cells and preservation of their mass are the current challenges that future antidiabetic drugs should meet for achieving efficient and long-term glycemic control in patients with type 2 diabetes (T2D). The successful development of glucagon-like peptide 1 (GLP-1) analogues, derived from the saliva of a lizard from the Helodermatidae family, has provided the proof of concept that antidiabetic drugs directly targeting pancreatic β-cells can emerge from venomous animals. The literature reporting on the antidiabetic effects of medicinal plants suggests that they contain some promising active substances such as polyphenols and alkaloids, which could be active as insulin secretagogues and β-cell protectors. In this review, we discuss the potential of several polyphenols, alkaloids and venom peptides from snake, frogs, scorpions and cone snails. These molecules could contribute to the development of new efficient antidiabetic medicines targeting β-cells, which would tackle the progression of the disease.

show abstract

“…Studies have demonstrated that SVMPs induce formation of blisters in the dermis and infiltration of leukocytes at the site of injection. Injection of SVMPs was also associated with degranulation of mast cells (which lead to histamine release, inducing vascular permeability and vasodilatation leading to extravasation), and the expression of messenger RNA (mRNA) encoding for tumor necrosis factor (TNF), interleukin-1 (IL-1), and interleukin-6 (IL-6) by elicited macrophages [86,89].…”

Section: Neurotherapeutics and Preconditioning In Surgical Brain Injurymentioning

confidence: 99%

Surgically-induced brain injury: where are we now?

et al. 2019

View full text Add to dashboard Cite

Neurosurgical procedures cause inevitable brain damage from the multitude of surgical manipulations utilized. Incisions, retraction, thermal damage from electrocautery, and intraoperative hemorrhage cause immediate and long-term brain injuries that are directly linked to neurosurgical operations, and these types of injuries, collectively, have been termed surgical brain injury (SBI). For the past decade, a model developed to study the underlying brain pathologies resulting from SBI has provided insight on cellular mechanisms and potential therapeutic targets. This model, as seen in a rat, mouse, and rabbit, mimics a neurosurgical operation and causes commonly encountered post-operative complications such as brain edema, neuroinflammation, and hemorrhage. In this review, we elaborate on SBI and its clinical impact, the SBI animal models and their clinical relevance, the importance of applying therapeutics before neurosurgical procedures (i.e., preconditioning), and the new direction of applying venom-derived proteins to attenuate SBI.

show abstract

Elevated plasma levels of hepatocyte growth factor in rats experimentally envenomated with Bothrops jararaca venom: Role of snake venom metalloproteases

Cited by 7 publications

References 62 publications

Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review

Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review

Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?

Surgically-induced brain injury: where are we now?

Contact Info

Product

Resources

About