2016
DOI: 10.7150/ijms.16187
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Elevated Plasma Matrix Metalloproteinase-9 and Its Correlations with Severity of Disease in Patients with Ventilator-Associated Pneumonia

Abstract: Ventilator-associated pneumonia (VAP) increases patient mortality and medical expenditure, and a real-time and reliable method for the rapid diagnosis of VAP may help reduce fatal complications. Matrix metalloproteinases-9 (MMP-9) is considered significant in the pathogenesis of lung inflammation and infection. Therefore, we examined its relationship with the clinical course of VAP. This retrospective observational study recruited 30 healthy volunteers, 12 patients who used mechanical ventilation without the d… Show more

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Cited by 11 publications
(17 citation statements)
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“…We found that the serum MMP-9 levels were significantly lower in PTB than in non-PTB patients, whereas Xu et al reported that serum MMP-9 levels were significantly higher in PTB than in non-PTB patients [13]. However, there are several reports of increased serum MMP-9 in patients with community-acquired or ventilator-associated pneumonia [29][30][31]. In contrast, Hrabec et al reported that the serum MMP-9 level was three times higher in patients with TB than in normal subjects [32].…”
Section: Discussionmentioning
confidence: 51%
See 1 more Smart Citation
“…We found that the serum MMP-9 levels were significantly lower in PTB than in non-PTB patients, whereas Xu et al reported that serum MMP-9 levels were significantly higher in PTB than in non-PTB patients [13]. However, there are several reports of increased serum MMP-9 in patients with community-acquired or ventilator-associated pneumonia [29][30][31]. In contrast, Hrabec et al reported that the serum MMP-9 level was three times higher in patients with TB than in normal subjects [32].…”
Section: Discussionmentioning
confidence: 51%
“…The classification tree method automatically chooses some appropriate markers and their cut-off values to divide patients into two groups according to its algorithm [22]. Although interpretation of the classification is sometimes difficult, it is possible that MMP-9 was chosen as a useful biomarker especially in patients with extensive infiltration because it was reported that plasma MMP-9 levels are associated with severity of ventilatorassociated pneumonia [29]. Therefore, the difference between PTB and non-PTB may become more apparent in patients with extensive infiltration.…”
Section: Discussionmentioning
confidence: 99%
“…The high concentrations of free amino acids as well C4-OH Pro in ETA suggest altered ECM integrity through collagen degradation. Effect of neutrophil metalloproteases on ECM modulation has been previously studied (41). The neutrophils are key players of pathological inflammation in lung infections such as VAP (42).…”
Section: Discussionmentioning
confidence: 99%
“…Ventilator-associated pneumonia (VAP) is a nosocomial pneumonia occurring more than 48 h after invasive mechanical ventilator support and is one of the most frequently diagnosed infectious diseases in the intensive care unit (ICU) [1,2]. Global incidence of VAP varies from 8 to 28% [3], and the development of VAP is associated with poor clinical outcome.…”
Section: Introductionmentioning
confidence: 99%