Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus

Wu, Guo-Cui; Yuan, Hui; Pan, Hai‐Feng; Ye, Dong‐Qing

doi:10.18632/oncotarget.13658

Cited by 15 publications

(12 citation statements)

References 30 publications

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“…Our result was consistent with Wu et al that there was no significant difference in serum Midkine levels in SLE patients with and without the renal disorder (P > 0.05). But, there was a significant difference in serum Midkine levels between flare and remission in our result (P = 0.018) contrary to a previous study (P > 0.05) [ 17 ]. In Rheumatoid Arthritis (RA), Shindo et al reported that MK level could be a biomarker of RA disease activity.…”

Section: Discussioncontrasting

confidence: 99%

“…Our result was comparable to a study conducted by Wu GC et al, that reported median Midkine levels were 698.37 (516.09-767.07) pg/ml and 628.22 (373.66-712.41) pg/ml in SLE patients and healthy control group. Our study result was consistent with Wu GC et al that Midkine serum levels were significantly increased in SLE patient (P < 0.05) [ 17 ]. Elevated Midkine serum level also occurs in other autoimmune diseases such as rheumatoid arthritis and multiple sclerosis [ 10 ] [ 18 ].…”

Section: Discussionsupporting

confidence: 93%

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Serum Midkine Levels in Systemic Lupus Erythematosus

Marpaung¹,

Ginting²,

Sjah³

2018

Open Access Maced J Med Sci

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BACKGROUND:Midkine (MK) induces inflammation and could inhibit inducible regulatory T cell differentiation. These reports suggest that MK may play a role in the pathogenesis of autoimmune disease including SLE, but data about MK in SLE patients was still limited, and the role of Midkine in SLE is largely unknown.AIM:The purpose of this study was to compare serum level MK in SLE patients and control, also analysed the relationship between the serum MK level and disease activity in SLE.METHODS:This cross-sectional study was conducted in Adam Malik Hospital from January-June 2017. Diagnosis of SLE was established according to the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, and disease activity was assessed using the Mexican Systemic lupus erythematosus disease activity index (MEX-SLEDAI). Subjects with evidence of malignancy and systemic disease (pulmonary, kidney, liver, metabolic disorder, etc.) were excluded. Data analysis was performed using SPSS 22nd version. P < 0.05 was considered statistically significant.RESULTS:There were 90 subjects and divided into 2 groups: SLE patients group (n=40) and healthy control groups (n = 50). Midkine levels were increased in the serum of SLE patients compared by health control. There was a significant difference in the median serum Midkine levels between SLE patients and healthy control (P < 0.001). Elevated Midkine serum levels were a significant difference between active disease and remission (P = 0.018).CONCLUSION:Elevated Midkine serum level could be a marker of SLE disease activity and have a role in the pathogenesis of SLE.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Serum Midkine Levels in Systemic Lupus Erythematosus

Marpaung¹,

Ginting²,

Sjah³

2018

Open Access Maced J Med Sci

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“…Increased levels of MK in autoimmune and inflammatory diseases have been shown in prior reports Our result was consistent with Salama et al which reported that MK levels in patients with Alzheimer's disease, as another neurological disease, is more than healthy persons (10). Plasma MK was elevated in patients with systemic lupus erythematosus which was correlated with IL-17 (11). In rheumatoid arthritis (RA) patients, high MK levels were found to implicated in the pathogenesis of RA and was associated with IL-6 and IL-8 (12,13).…”

Section: Discussionsupporting

confidence: 91%

The Effects of 3,4-methylenedioxy- methamphetamine on Neurogenesis in the Hippocampus of Male Rats

Asl

Moravej

Kowsari

et al. 2020

Basic Clin. Neurosci. J.

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Introduction: Midkine (MK), a heparin-binding growth factor, is involved in neurological diseases by mediating the inflammatory responses through enhancing the leukocyte migration. The present study assesses the serum concentration of this growth factor among newly multiple sclerosis (MS) and neuromyelitis optica (NMO). Methods: The present research, as a cross-sectional study, which performed at Isfahan University of Medical Sciences. All samples were selected from patients who visited Kashani and Alzahra hospital during two years 2014-2016. The MK level was assessed in 80 new cases of MS, 80 NMO patients and 80 healthy subjects. After collecting blood sera samples, MK serum level was measured using the ELISA. Data were analyzed by SPSS statistical software. Results: The mean of MK level was 1038.58 ± 44.73 pg/ml in MS group, which was significantly higher compared with the mean of MK level in NMO (872.62 ± 55.42 pg/ml) and control groups (605.02 ± 9.42 pg/ml). Conclusion: Overall, these results demonstrated MK plays a prominent role in inflammatory reactions and also in neuroautoimmune diseases, especially in MS. So, the MK level may be applied to earlier diagnosis and also prevention of disease progression by using a special inhibitor.

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“…We previously reported elevated plasma MK and PTN concentrations in SLE compared with healthy controls, and the increase in MK and PTN levels correlated with inflammatory cytokine IL-17 and some clinical features/parameters, including rash and anti-SSA antibody, suggesting that an aberrant expression of MK and PTN might be involved in the progress of inflammation and the course of SLE (25).…”

Section: Discussionmentioning

confidence: 90%

“…In rheumatoid arthritis (RA), a study has found an increased serum MK level in RA patients and its correlation with disease activity score (DAS) 28-erythrocyte sedimentation rate (ESR) and rheumatoid factors (RFs) titer (24). Our previous study has revealed that, as compared to healthy controls, the levels of plasma MK and PTN are elevated in SLE and also associated with interleukin (IL)-17 levels and some clinical manifestations, including rash and anti-Sjögren's-syndrome-related antigen A (anti-SSA) (25). These findings suggest a potential role of MK and PTN involved in certain types of autoimmune diseases.…”

Section: Introductionmentioning

confidence: 98%

Association of Midkine and Pleiotrophin Gene Polymorphisms With Systemic Lupus Erythematosus Susceptibility in Chinese Han Population

et al. 2020

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In a previous study, we have reported an increased plasma midkine (MK) and pleiotrophin (PTN) concentrations in patients with systemic lupus erythematosus (SLE) and the increase in MK and PTN associated with inflammatory cytokines interleukin (IL)-17 level and some clinical manifestations, suggesting the underlying association of MK and PTN with SLE. This study was conducted to investigate the association between common single-nucleotide polymorphisms (SNPs) in the MK and PTN gene and SLE susceptibility. A total of 989 subjects (496 SLE patients and 493 healthy controls) were included and genotyped for three MK SNPs and seven PTN SNPs in using improved multiple ligase detection reaction (iMLDR). Results have demonstrated no significant differences for genotype and allele frequencies in all 10 SNPs between SLE patients and healthy controls. Case-only analysis in SLE revealed that, in MK gene, the genotype frequency of AA/AG (rs35324223) was significantly lower in patients with photosensitivity than those without; the allele frequency of A/G (rs20542) was significantly higher in patients without serositis. In PTN gene, the A/G allele frequency (rs322236), C/T allele frequency, and TT/CT genotype frequency (rs6970141) showed significantly increased results in patients with immunological disorder compared to those without. Furthermore, no significant differences in plasma MK and PTN concentrations with its SNPs genotypes were found. MK and PTN SNPs showed no associations with SLE genetic susceptibility, but it may be associated with the course of this disease; further studies are needed to focus on the mechanism of MK and PTN genes in the pathogenesis of SLE.

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Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus

Cited by 15 publications

References 30 publications

Serum Midkine Levels in Systemic Lupus Erythematosus

Serum Midkine Levels in Systemic Lupus Erythematosus

The Effects of 3,4-methylenedioxy- methamphetamine on Neurogenesis in the Hippocampus of Male Rats

Association of Midkine and Pleiotrophin Gene Polymorphisms With Systemic Lupus Erythematosus Susceptibility in Chinese Han Population

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