Elevated plasma osteopontin level is predictive of cirrhosis in patients with hepatitis B infection

Abstract

These data suggest that OPN could be used to evaluate the existence of LC, as OPN has previously been reported to be increased in the HCC; this unique feature makes OPN a promising candidate for prediction biomarker in the long-time surveillance of patients with HBV infection to evaluate the risk of cirrhosis and cancer.

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

“…OPN also delays liver fibrosis resolution due to sustained fibrillar collagen-I deposition in mice after thioacetamide-induced fibrosis [7] . Recently, plasma OPN levels have been found to predict liver fibrosis in various chronic liver diseases, such as NASH [11] , alcoholic liver disease [12] , and chronic viral hepatitis B [13] and C [14] . Pereira et al [21] have also demonstrated that OPN secretion could be stimulated by Schistosoma mansoni and that serum OPN levels correlated with splenic vein pressure and liver fibrosis stage in patients with schistosomiasis.…”

“…In fact, plasma OPN levels have been found to be significantly elevated in patients with liver cirrhosis and HCC compared to those without HCC [10] . Recently, plasma OPN levels were shown to predict liver fibrosis in various chronic liver diseases, such as non-alcoholic steatohepatitis [11] , alcoholic liver disease [12] , and chronic viral hepatitis B [13] and C [14] . As OPN levels correlate significantly with the fibrosis stage in alcohol-induced liver disease [12] , it follows that OPN levels could be related to the degree of portal hypertension and, hence, serve as a surrogate non-invasive marker of portal hypertension.…”

Serum osteopontin is a predictor of prognosis for HBV‑associated acute‑on‑chronic liver failure

“…A number of studies have suggested that OPN may serve as a biomarker of severe fibrosis and portal hypertension during Schistosomiasis mansoni (8) and chronic viral hepatitis (9,10). Nevertheless, in mice models of liver injury induced by diethylnitrosamine or ischemia/reperfusion, OPN exerted a protective effect by ameliorating the production of IL-6 and TNF-α in macrophages and inhibiting inflammation (11,12).…”

Serum Osteopontin and Cytokeratin-18 in Chronic Hepatitis C Patients

“…In ROC curve for the discrimination of F1/F2 from F3/F4, the AUC of serum OPN was 0.99. Furthermore, circulating OPN level is characterized as an excellent predictor of cirrhosis in patients with hepatitis B infection [13]. Overall, it was observed that, OPN level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease.…”