Elevated Platelet Parameter in First-Episode Schizophrenia Patients: A Cross-Sectional Study

Yu, Qi; Weng, Wujin; Zhou, Hongfei; Tang, Yamei; Ding, Shan; Huang, Kai; Liu, Yong

doi:10.1089/jir.2020.0117

Cited by 21 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, there was no significant increase in PLT, MPV, and PCT values in ADHD patients. Abnormal (very low or very high) levels of platelet counts and MPV parameters have also been reported in the literature on psychiatric disorders such as schizophrenia, unipolar depression, and bipolar disorder (Yu et al, 2020 ; Wysokiński & Szczepocka, 2016 ). Significantly higher MPV values were also reported in children with ADHD than in the healthy control group (Yorbik et al, 2014 ).…”

Section: Discussionmentioning

confidence: 82%

New Hematological Parameters as Inflammatory Biomarkers: Systemic Immune Inflammation Index, Platerethritis, and Platelet Distribution Width in Patients with Adult Attention Deficit Hyperactivity Disorder

Ceyhun

Gürbüzer

2022

Adv Neurodev Disord

View full text Add to dashboard Cite

Objectives The potential role of neuroinflammation in adult attention deficit hyperactivity disorder (ADHD) patients has been investigated with peripheral hemogram-related inflammatory markers. Systemic immune inflammation index (SII) is defined as a new index that has been developed for the balance of inflammatory and immune status. Methods Our study was based on a prospective routine complete blood count(CBC) analysis of 74 Adult ADHD patients and 70 healthy participants. The DSM-5-Clinician version and Barratt impulsivity scale-11 were used to evaluate the participants. Results There was no statistical difference in the comparison of the SII ratios, platelet distribution width (PDW), and plateretritis (PCT) ( p >0.05 for each) in a group of a young adults with ADHD and in a comparison control group. These inflammatory indicators were found to be similar between patients newly diagnosed with ADHD ( n =40) and patients using methylphenidate ( n =34) ( p >0.05 for each). The relationship between ADHD clinical symptoms and severity and inflammation was evaluated. A significant negative correlation was observed between attention deficit scores and PCT ( r =−0.301, p =0.009). A positive significant correlation was found between hyperactivity scores and SII ( r =0.247, p =0.034). A significant positive correlation was found between Barrat motor scores and PDW( r =241, p =0.038). In the regression analysis, the PCT variable changed the attention deficit variable ( β =.33, t (70)= −2.703, p =.009, pr 2 = .094) predicted negatively and significantly. Conclusions We demonstrated the association of SII, which is independently associated with adverse outcomes in many diseases, and the severity of hyperactivity symptoms in adult ADHD. The fact that PCT predicts attention deficit negatively and decisively shows the importance of inflammatory assessments specific to clinical presentations. The critical importance of platelets in inflammatory processes in ADHD has been demonstrated once again with inflammatory markers such as SII, PLT, and PDW, which can be accessed by an easily applicable complete blood count method.

show abstract

Section: Discussionmentioning

confidence: 82%

New Hematological Parameters as Inflammatory Biomarkers: Systemic Immune Inflammation Index, Platerethritis, and Platelet Distribution Width in Patients with Adult Attention Deficit Hyperactivity Disorder

Ceyhun

Gürbüzer

2022

Adv Neurodev Disord

View full text Add to dashboard Cite

show abstract

“…The eighteen studies ( 17 , 35 , 37 , 38 , 41 , 42 , 46 – 49 , 52 – 56 , 102 ) selected in this meta-analysis were published between 2015 and 2021, and consisted of 2,264 depression cases and 2,415 controls. As displayed in Table 1 , we summarized the main characteristics of these studies.…”

Section: Resultsmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis

Cheng

Wang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundResearch on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in depression is still emerging and has increased 3-fold since the first meta-analysis. An updated meta-analysis with sufficient studies can provide more evidence for a potential relationship between NLR, PLR, MLR, and depression.MethodsWe identified 18 studies from the PubMed, EMBASE, Cochrane library, and Web of Science databases. Meta-analyses were performed to generate pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) between patients with depression and controls. Sensitivity analysis, subgroup analysis, meta-regression, and publication bias were conducted.ResultsA total of 18 studies including 2,264 depressed patients and 2,415 controls were included. Depressed patients had significantly higher NLR and PLR compared with controls (SMD = 0.33, 95% CI: 0.15–0.52, p < 0.001 and SMD = 0.24, 95% CI: 0.02–0.46, p < 0.05, respectively). MLR was slightly higher in depressed individuals compared to controls (SMD = 0.15, 95% CI: −0.26 to 0.55, p > 0.05), despite the absence of significance. Sensitivity analysis removing one study responsible for heterogeneity showed a higher and significant effect (SMD = 0.32, 95% CI: 0.20–0.44) of MLR. Three subgroup analyses of NLR, PLR, MLR, and depression revealed obvious differences in the inflammatory ratios between depressed patients and controls in China and the matched age and gender subgroup. Individuals with post-stroke depression (PSD) had higher NLR and MLR values as compared to non-PSD patients (SMD = 0.51, 95% CI: 0.36–0.67, p < 0.001 and SMD = 0.46, 95% CI: 0.12–0.79, p < 0.01, respectively). Meta-regression analyses showed that male proportion in the case group influenced the heterogeneity among studies that measured NLR values (p < 0.05).ConclusionsHigher inflammatory ratios, especially NLR, were significantly associated with an increased risk of depression. In the subgroup of China and matched age and gender, NLR, PLR, and MLR were all elevated in depressed patients vs. controls. Individuals with PSD had higher NLR and MLR values as compared to non-PSD patients. Gender differences may have an effect on NLR values in patients with depression.

show abstract

“…We reported that higher preoperative NLR was associated with the development of postoperative delirium that is also caused by neuroinflammation 6 , 7 . In addition, several studies reported that the NLR and the PLR were associated with generated psychiatric diseases, schizophrenia, attention-deficit/hyperactivity disorder (ADHD), and epileptic seizure 8 – 10 . Several studies demonstrated that the NLR was significantly higher in patients with depression 11 – 14 , and a study demonstrated that the PLR was significantly higher in patients with severe depression plus psychotic features compared to patients with mild-to-severe depression 15 .…”

Section: Introductionmentioning

confidence: 99%

Higher neutrophil–lymphocyte ratio is associated with depressive symptoms in Japanese general male population

Kinoshita

Takekawa

Kudo

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Relationships between the neutrophil–lymphocyte ratio (NLR) and/or the platelet-lymphocyte ratio (PLR) and neuroinflammatory diseases have been reported. Depression is also associated with neuroinflammation. Here, we determined the association between the NLR, PLR, and depressive symptoms. This cross-sectional study is a secondary analysis of the data of the Iwaki Health Promotion Project 2017. We analyzed the characteristics and laboratory data of 1,015 Japanese subjects (597 females, 408 males) including their NLR and PLR values. We assigned the subjects with a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16 to the depressive symptoms group. We performed a multivariate logistic regression analysis to determine whether the NLR and/or PLR were associated with depressive symptoms (CES-D ≥ 16). Two hundred subjects (19.7%; 122 [20.4%] females, 78 [19.1%] males) were assigned to the depressive symptoms group. There were significant differences between the non-depressive symptoms and depressive symptoms groups in the NLR [median (25th to 75th percentile): 1.54 (1.24, 1.97) vs. 1.76 (1.32, 2.37), P = 0.005] and the PLR [median (25th to 75th percentile): 123.7 (102.0, 153.9) vs. 136.8 (107.0, 166.5), P = 0.047] in males, but not in females. The multivariate logistic regression analysis demonstrated that the NLR was significantly associated with depressive symptoms in males (adjusted odds ratio: per 1 increase, 1.570; 95% confidence interval: 1.120–2.220; P = 0.009). In conclusion, our findings indicate that higher NLR may be associated with depressive symptoms in males.

show abstract

Elevated Platelet Parameter in First-Episode Schizophrenia Patients: A Cross-Sectional Study

Cited by 21 publications

References 38 publications

New Hematological Parameters as Inflammatory Biomarkers: Systemic Immune Inflammation Index, Platerethritis, and Platelet Distribution Width in Patients with Adult Attention Deficit Hyperactivity Disorder

New Hematological Parameters as Inflammatory Biomarkers: Systemic Immune Inflammation Index, Platerethritis, and Platelet Distribution Width in Patients with Adult Attention Deficit Hyperactivity Disorder

Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis

Higher neutrophil–lymphocyte ratio is associated with depressive symptoms in Japanese general male population

Contact Info

Product

Resources

About