Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles

Rabin, Bernard M.; Carrihill-Knoll, Kirsty L.; Carey, Amanda N.; Shukitt‐Hale, Barbara; Joseph, James A.; Foster, Brian

doi:10.1016/j.asr.2006.11.013

Cited by 23 publications

(14 citation statements)

References 33 publications

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“…In contrast, the older rats exposed to 1000 MeV/n 28 Si particles required a higher dose to disrupt recognition memory compared to the younger subjects (50 cGy in the older animals compared to 25 cGy in the younger animals; Figure 3E, Figure 3F). However, as noted with the results following exposure to 16 O particles, the increase in the dose needed to disrupt recognition memory in the rats when retested nine months following the original test may have resulted from the reduction in the percentage of time the non-irradiated control rats spent exploring the novel object. Because the measure of the performance of the younger control subjects was not reliable (only 3 non-irradiated controls met criterion on the first test), it was not possible to statistically compare the performance of the radiated and control subjects.…”

Section: Resultsmentioning

confidence: 87%

“…When retested 8 months following the first test the non-irradiated controls (0 cGy) showed a reduction in the percentage of time spent with the novel object, failing to show a significant preference for the novel object. As such, there was no difference between the rats exposed to 16 O particles and the non-irradiated controls. With regard to the rats exposed to 28 Si particles, the effect of irradiation on cognitive function at two ages varied as a function of particle energy.…”

Section: Resultsmentioning

confidence: 87%

“…The major exceptions to the observation that lower doses of HZE particles were needed to disrupt cognitive performance in the older subjects were in the animals exposed to the two energies of 16 O particles (600 and 1000 MeV/n) and to 28 Si particles (600 and 1000 MeV/n), although the reasons for this were different for the two particles. The performance of the younger animals exposed to the different doses of 16 O particles showed a significant reduction in object recognition memory compared to the non-irradiated controls (Figure 1).…”

Section: Resultsmentioning

confidence: 94%

“…The performance of the younger animals exposed to the different doses of 16 O particles showed a significant reduction in object recognition memory compared to the non-irradiated controls (Figure 1). When retested 8 months following the first test the non-irradiated controls (0 cGy) showed a reduction in the percentage of time spent with the novel object, failing to show a significant preference for the novel object.…”

Section: Resultsmentioning

confidence: 99%

“…Similar results have been obtained when older rats (7 -18 months of age) have been exposed 56 Fe particles. The doses needed to disrupt performance of older rats on operant responding (a measure of motivation to respond to changes in reinforcement contingencies [12]) and on plus-maze performance (a measure of baseline anxiety levels [16]) are significantly lower than the doses needed to disrupt the performance of younger rats. Also similar to previous results [11] is the observation (Figure 1) that once threshold is reached it is possible that a higher dose will not disrupt performance.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Age on the Disruption of Cognitive Performance by Exposure to Space Radiation

Rabin¹,

Shukitt‐Hale²,

Carrihill-Knoll³

2014

JBBS

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Exposure to low doses of heavy particles and protons, which will be encountered during long-term exploratory class missions to other planets, can cause deficits in cognitive performance. These deficits are similar to those observed in aged animals. The long-term effects of such exposures and their relationship to the short-term effects and to aging remain to be established. Two-month old rats were exposed to a variety of heavy particles and protons. Recognition memory was tested at two time points following irradiation. The results showed that exposure to doses of radiation that did not disrupt cognitive performance in the younger animals, disrupted performance when the subjects were re-tested at an older age. These results indicate that there is an interaction between the age of the organism and the effects of exposure to space radiation on cognitive performance, such that exposure to doses of heavy particles or protons that may not produce an initial effect on cognitive performance may produce an effect as the organism ages. Because of the interaction between exposure to the types of radiation encountered in space and age, it is possible that participating in exploratory class missions may have consequences for the quality of life after the conclusion of the mission.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Age on the Disruption of Cognitive Performance by Exposure to Space Radiation

Rabin¹,

Shukitt‐Hale²,

Carrihill-Knoll³

2014

JBBS

Self Cite

View full text Add to dashboard Cite

show abstract

Lack of reliability in the disruption of cognitive performance following exposure to protons

Rabin¹,

Heroux²,

Shukitt‐Hale

et al. 2015

Radiat Environ Biophys

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A series of three replications were run to determine the reliability with which exposure to protons produces a disruption of cognitive performance, using a novel object recognition task and operant responding on an ascending fixed-ratio task. For the first two replications, rats were exposed to head-only exposures to 1000 MeV/n protons at the NASA Space Radiation Laboratory. For the third replication, subjects were given head-only or whole-body exposures to both 1000 and 150 MeV/n protons. The results were characterized by a lack of consistency in the effects of exposure to protons on the performance of these cognitive tasks, both within and between replications. The factors that might influence the lack of consistency and the implications for exploratory class missions are discussed.

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Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Carrihill-Knoll

Rabin

Shukitt‐Hale

et al. 2007

AGE

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Exposure to 56 Fe particles produces changes in dopaminergic function and in dopaminedependent behaviors, including amphetamine-induced conditioned taste aversion (CTA) learning. Because many of these changes are characteristic of the changes that accompany the aging process, the present study was designed to determine whether or not there would be an interaction between age and exposure to 56 Fe particles in the disruption of an amphetamine-induced CTA. One hundred and forty F-344 male rats 2-, 7-, 12-, and 16-months old, were radiated with 56 Fe particles (0.25-2.00 Gy, 1 GeV/n) at Brookhaven National Laboratory. Three days following irradiation, the rats were tested for the effects of radiation on the acquisition of a CTA produced by injection of amphetamine (3 mg/kg, i.p.). The main effect of age was to produce a significant decrease in conditioning day sucrose intake; there was no affect of age on the acquisition of the amphetamine-induced CTA. Exposing rats to 56 Fe particles disrupted the acquisition of the CTA produced by injection of amphetamine only in the 2-month-old rats. These results do not support the hypothesis of an interaction between age and exposure to 56 Fe particles in producing a disruption of amphetamine-induced CTA learning. As such, these results suggest that the aging produced by exposure to 56 Fe particles may be endpoint specific.

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Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles

Cited by 23 publications

References 33 publications

Effects of Age on the Disruption of Cognitive Performance by Exposure to Space Radiation

Effects of Age on the Disruption of Cognitive Performance by Exposure to Space Radiation

Lack of reliability in the disruption of cognitive performance following exposure to protons

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

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