Elevated preoperative serum cancer antigen 15.3 levels are associated with reduced disease-free survival: a single-institution experience

Abstract

Elevated preoperative CA 15.3 above 35 U/mL in Saudi women breast cancer patients showed correlation with primary tumor size and nodal status, and preoperative CA 15.3 level is an independent prognostic factor for DFS. Preoperative serum CA 15.3 levels may be helpful for risk stratification along with other factors.

The Significance of Cea and Ca15-3 in Early Breast Cancer Its Association With Clinico Pathological Characteristics a Single-Center Study in Madinah, Saudi Arabia

“…The results of this study including 135 women with breast cancer showed that preoperative CA15-3 levels were correlated with tumor size. Correlation of preoperative serum CA 15.3 levels with primary tumor size in patients with breast cancer has been demonstrated in Western data, however, the impact of preoperative CA 15.3 levels in Middle Eastern women with breast cancer has not been well studied [17,18]. The preoperative serum CEA and CA 15-3 levels are associated with the tumor size and lymph node metastasis which represents tumor burden [15,16] and 1086 significantly higher levels of CEA and CA 15-3 were seen in patients with advanced disease than in those with locoregional breast cancer [19].…”