Elevated preradiotherapy serum lactate dehydrogenase predicts distant metastasis for lymphoepithelial carcinoma of major salivary gland following postoperative radiotherapy

Abstract

Background To evaluate the predicting factors associated with distant metastasis (DM) for lymphoepithelial carcinoma of salivary gland (LECSG) following postoperative radiotherapy (PORT). Methods We retrospectively collected 160 eligible patients from two cancer institutions. The DM rate was evaluated using competing risk method. Results The median follow‐up time was 65.6 months. Elevated preradiotherapy serum LDH (ratio >0.5) (p = 0.006) and N classification (N2‐3) (p = 0.001) were independently associated with DM for the LECSG. After the risk stratification, the high‐risk subgroup was defined as the patients presented higher risk score (score >0), whereas 5‐year cumulative incidence of DM in the high‐ and low‐risk group was 30.9% and 6.0%, respectively (p < 0.001). Moreover, a significantly worse overall survival (OS) was observed in the high‐risk patients compared with the low‐risk subgroup (5‐year OS: 83.9% vs. 97.8%, p = 0.006). Conclusion Elevated preradiotherapy serum LDH could serve as a predictive factor for DM in the LECSG following PORT.

Influence of parotid lymph node metastasis on distant metastasis in parotid gland cancer

“…Another report identified 884 patients (14), and 15% of the population suffered from DM after initial treatment; the factors remaining significant in predicting shorter DMFS were male sex, advanced T or N classifications, and high pathologic grade. Similar findings were described by Lim et al ( 16) and Yan et al (17). Our study would also support the effect of common adverse pathologic variables on DM; however, the above-mentioned…”

“…( 16 ) and Yan et al. ( 17 ). Our study would also support the effect of common adverse pathologic variables on DM; however, the above-mentioned studies neglected the impact of metastatic parotid LNs, and did not analyze this variable in multivariate analyses.…”