Elevated Presepsin Levels are Associated with Severity and Prognosis of Severe Acute Pancreatitis

Lin, Jinkun; Li, Zhe; Zheng, Yanhong; Zhang, Yang; Shao, Chengchen; Liu, Gongpan; Li, Jiangong

doi:10.7754/clin.lab.2016.160134

Cited by 3 publications

(1 citation statement)

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“…Masson et al [ 10 ] found that presepsin levels are significantly higher in septic patients with shock than those without shock. A gender- and age-matched study on patients with severe AP and healthy volunteers showed that presepsin was an independent predictor of local complications, organ failure and in-hospital mortality[ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Dynamic blood presepsin levels are associated with severity and outcome of acute pancreatitis: A prospective cohort study

Xiao¹,

Wang²,

Wang³

et al. 2022

WJG

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BACKGROUND Acute pancreatitis (AP) is an inflammatory disorder of the pancreas with an unpredictable course of illness. A major challenge of AP is the early identification of patients at high-risk for organ failure and death. However, scoring systems are complicated and time consuming, and the predictive values for the clinical course are vague. AIM To determine whether the dynamic changes in presepsin levels can be used to evaluate the severity of disease and outcome of AP. METHODS In this multicentric cohort study, 133 patients with AP were included. Clinical severity was dynamically evaluated using the 2012 revised Atlanta Classification. Blood presepsin levels were measured at days 1, 3, 5 and 7 after admission by chemiluminescent enzyme immunoassay. RESULTS The median concentration of presepsin increased and the clearance rate of presepsin decreased with disease severity and organ failure in AP patients. The presepsin levels on days 3, 5 and 7 were independent predictors of moderately severe and severe AP with time-specific area under the curve (AUC) values of 0.827, 0.848 and 0.867, respectively. The presepsin levels positively correlated with bedside index of severity in AP, Ranson, acute physiology and chronic health evaluation II, computed tomography severity index and Marshall scores. Presepsin levels on days 3, 5 and 7 were independent predictors of 28-d mortality of AP patients with AUC values of 0.781, 0.846 and 0.843, respectively. CONCLUSION Blood presepsin levels within 7 d of admission were associated with and may be useful to dynamically predict the severity of disease course and 28-d mortality in AP patients.

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Section: Discussionmentioning

confidence: 99%

Dynamic blood presepsin levels are associated with severity and outcome of acute pancreatitis: A prospective cohort study

Xiao¹,

Wang²,

Wang³

et al. 2022

WJG

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Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study

Handke

Scholz

Gillmann

et al. 2019

Anesthesia &Amp; Analgesia

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Noncardiac surgery was associated with an increase in atherogenic leukocyte subsets. In a post hoc analysis, elevated pre-OP presepsin was associated with MACCE and improved NT-proBNP-based risk assessment. After validation in an independent data set, a presepsin cutoff of 184 pg·mL might qualify to complement NT-proBNP-based risk prediction, thereby increasing the proportion of correctly identified high-risk patients.

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Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty: A prospective observational study

Bizzoca¹,

Piazzolla²,

Moretti³

et al. 2023

World J Orthop

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Shoulder pain is a common musculoskeletal complaint, and rotator cuff (RC) pathologies are one of the main causes. The RC undergoes various tendinopathic and avascular changes during the aging process. Other degenerative changes affecting its healing potential make it an appealing target for biological agents. Platelet-rich plasma (PRP) has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators, and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle, ligaments, and tendinous cells. This review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical evidence. Due to the different characteristics and conflicting outcomes, clinicians should use PRP with moderate expectations until more consistent evidence is available. However, it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate healing. Its autologous origin makes it a safe treatment, and its characteristics make it a promising option for treating RC tendinopathy, but the efficacy has yet to be established.

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Elevated Presepsin Levels are Associated with Severity and Prognosis of Severe Acute Pancreatitis

Abstract: Increased presepsin level was found to be an accurate predictor of disease severity and identified as a novel prognostic marker of local complications, organ failure, and mortality of SAP.

Cited by 3 publications

References 0 publications

Dynamic blood presepsin levels are associated with severity and outcome of acute pancreatitis: A prospective cohort study

Dynamic blood presepsin levels are associated with severity and outcome of acute pancreatitis: A prospective cohort study

Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study

Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty: A prospective observational study

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