Elevated Prevalence of Generalized Anxiety Disorder in Adults With 22q11.2 Deletion Syndrome

Fung, Wai Lun Alan; McEvilly, Rebecca; Fong, Jessica; Silversides, Candice; Chow, Eva W.C.; Bassett, Anne S.

doi:10.1176/appi.ajp.2010.09101463

Cited by 87 publications

(126 citation statements)

References 3 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…19,22 The majority of subjects were ascertained through adult congenital cardiac, psychiatric, or genetics services as described previously. 4,19 Written informed consent was obtained for all subjects, and the study was approved by local research ethics boards.…”

Section: Discussionmentioning

confidence: 99%

“…4,15,[19][20][21][22][23][24] Purpose: Schizophrenia occurs in 20-25% of adults with 22q11.2 deletion syndrome (22q11.2DS). General population studies of schizophrenia report associations with perinatal complications, although effect sizes are generally low.…”

Section: Subjectsmentioning

confidence: 99%

“…There were no cases with absence of prenatal care, history of assisted reproduction, or extremes of maternal age (i.e., <17 or >40 years). 29,30 Psychiatric diagnosis and outcome variables As before, 4,13,20,21,23,24 we (A.S.B. or E.W.C.C.)…”

Section: Clinical Predictor Variablesmentioning

confidence: 99%

“…1,2 About one in four individuals with 22q11.2DS develops schizophrenia in late adolescence or early adulthood. 2,4,5 Identifying factors that may influence the 20-to 25-fold elevated risk for schizophrenia in 22q11.2DS is a matter of intense interest to patients, families, clinicians, and researchers. 6 Multiple general population-based studies of schizophrenia have reported associations with adverse perinatal outcomes, especially small for gestational age (SGA) birth weight and late prematurity, [7][8][9][10] although effect sizes are generally low.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Van

Butcher

Costain

et al. 2016

Genetics in Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Clinical Predictor Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Van

Butcher

Costain

et al. 2016

Genetics in Medicine

View full text Add to dashboard Cite

“…The penetrance P for schizophrenia in 22q11.2DS is B0.25 (25%). 7 Individuals with 22q11.2DS and schizophrenia have approximately one tenth as many children as do individuals with 22q11.2DS and without schizophrenia, and thus the relative fitness f associated with schizophrenia in 22q11.2DS is B0.10 (10%). 6 The observed penetrance of schizophrenia in transmitting parents with 22q11.2DS would therefore be on the order of 0.03 (3%) (Figure 1; Supplementary Table S2).…”

Section: Lettersmentioning

confidence: 99%

Parental expression is overvalued in the interpretation of rare inherited variants

Costain

2014

Eur J Hum Genet

View full text Add to dashboard Cite

TL studies (paired t-test, P ¼ 0.05, Table 1 by Eisenberg 10 ). If lower paternal survival is associated with increased incidence of critically short TLs, the paternal TL distribution will be truncated leading to lower father-offspring correlations in older populations. Tentatively suggestive that this explanation is worthy of further consideration, across the limited set of available populations (n ¼ 8), there is a nonsignificant trend toward greater fatheroffspring correlations (relative to mother-offspring correlations, difference) in studies with increasing numbers of father-offspring pairs (relative to mother-offspring pairs, ratio; Pearson correlation, r ¼ 0.37, P ¼ 0.37).As suggested above, biological phenomena may provide particularly important explanations for the inheritance discrepancy before fertilization, whereas methodology-associated biases may arise more after birth. A large-scale TL inheritance study of neonatal offspring along with both parents might identify whether biology or methodology lies at the origin of the observed discrepancy. Methodology-induced biases will most likely be related to measurement method, parental age at conception, parental and offspring age at measurement, and parental survival. Statistical adjustment for the latter variables, or selection of appropriate population subsets might allow discernment of the effect(s) at play. The use of nonparametric statistics or bettervalidated TL measurements might eliminate the possibility that the discrepancies are related to nonlinearity in the TL measurement scale. In summary, there are several possible explanations for the parental TL inheritance discrepancy, and the net effect most likely depends on the specific study design and characteristics of the included populations. A novel (meta-)analysis of the different data sets adjusting for the above-suggested putative confounding variables might enable the identification of the underlying mechanism, or at least might eliminate several methodological possibilities.

show abstract

Movement disorders and other motor abnormalities in adults with 22q11.2 deletion syndrome

Boot¹,

Butcher

Amelsvoort

et al. 2015

American J of Med Genetics Pt A

Self Cite

View full text Add to dashboard Cite

Movement abnormalities are frequently reported in children with 22q11.2 deletion syndrome (22q11.2DS), but knowledge in this area is scarce in the increasing adult population. We report on five individuals illustrative of movement disorders and other motor abnormalities in adults with 22q11.2DS. In addition to an increased susceptibility to neuropsychiatric disorders, seizures, and early-onset Parkinson disease, the underlying brain dysfunction associated with 22q11.2DS may give rise to an increased vulnerability to multiple movement abnormalities, including those influenced by medications. Movement abnormalities may also be secondary to treatable endocrine diseases and congenital musculoskeletal abnormalities. We propose that movement abnormalities may be common in adults with 22q11.2DS and discuss the implications and challenges important to clinical practice.

show abstract

Elevated Prevalence of Generalized Anxiety Disorder in Adults With 22q11.2 Deletion Syndrome

Cited by 87 publications

References 3 publications

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Parental expression is overvalued in the interpretation of rare inherited variants

Movement disorders and other motor abnormalities in adults with 22q11.2 deletion syndrome

Contact Info

Product

Resources

About