Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression

Ezzat, Mohamed; El-Gammasy, T Mohey; Shaheen, Karim Y.; Osman, Aiman Osman Yousef

doi:10.1111/j.1756-185x.2011.01632.x

Cited by 33 publications

(30 citation statements)

References 19 publications

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“…The results of our study were comparable with those reported in literature. Previous studies documented the changed levels of galectin-3 in patients with RA, juvenile idiopathic arthritis (JIA), SSc, ankylosing spondylitis (AS) or Behcet's diseases (BD) [6,[21][22][23][24]. For example, Ohshima et al has demonstrated increased levels of galectin-3 both in RA synovial uid and serum in comparison to patients with osteoarthritis and healthy subjects [6].…”

Section: Discussionmentioning

confidence: 99%

Galectin-3: A Potential Biomarker of Rheumatic Diseases

Gruszewska

Cylwik

Gińdzieńska-Sieśkiewicz

et al. 2020

Preprint

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Background: The purpose of our study was to assess the serum galectin-3 level and its potential association with disease activity and severity indexes in patients with rheumatic diseases.Methods: Eighty-two patients with rheumatoid arthritis (RA), 49 patients with systemic sclerosis (SSc), and 18 patients with systemic lupus erythematosus (SLE) were enrolled in this study. The control group comprised 30 healthy controls. Galectin-3 concentration in serum was measured using immunochemical method. Results: The galectin-3 concentration were significantly elevated in the RA, SSc and SLE in comparison to the control group (P=0.000, P=0.000, P<0.001; respectively). But there were no significant differences in the serum galectin-3 levels between rheumatic diseases (H=0.395, P=0.821). In RA and SSc patients, galectin-3 positively correlated with erythrocyte sedimentation rate (R=0.332, P=0.004; R=0.384, P=0.009; respectively). The diagnostic accuracy (ACC) of galectin-3 was high in all rheumatic diseases (87.5% for RA, 83.1% for SSc, 81.1% for SLE). ROC analysis revealed that galectin-3 had an excellent diagnostic power in RA (AUC=0.911) and SSc (AUC=0.903) and very good for SLE (AUC=0.859).Conclusions: We concluded that serum galectin-3 due to the high diagnostic power can be a very good laboratory marker in RA and SSc patients and a useful tool in the diagnosis of SLE.

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Section: Discussionmentioning

confidence: 99%

Galectin-3: A Potential Biomarker of Rheumatic Diseases

Gruszewska

Cylwik

Gińdzieńska-Sieśkiewicz

et al. 2020

Preprint

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“…Furthermore, a study of plasma galectin‐3 showed increased concentrations in septicaemia but not in viral infections or in attacks of nondetermined autoinflammatory syndromes, as compared to healthy controls . The increase of galectin‐3 in several other inflammatory conditions has been reported, including systemic lupus erythematosus (SLE) , Behçet's disease and juvenile idiopathic arthritis , as well as in Crohn's disease and ulcerative colitis . If the findings of increased plasma levels of galectin‐3 in other inflammatory diseases and low levels in PFAPA are verified, galectin‐3 might be used as tool to distinguish these conditions from PFAPA, particularly with regard to young children who originate in regions with a high prevalence of FMF.…”

Section: The Continuum Model Of Immunological Diseasesmentioning

confidence: 94%

Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome

et al. 2016

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There have been remarkable developments in the field of autoinflammatory diseases over the last 20 years. Research has led to definitions of new conditions, increased understanding of disease mechanisms and specific treatment. The polygenic autoinflammatory condition of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) is the most common autoinflammatory disorder among children in many parts of the world. The clinical features often include clockwork regularity of episodes, prompt responses to corticosteroids and therapeutic effects of tonsillectomy, but the disease mechanisms are largely unknown. Conclusion This review discusses the emerging understanding of autoinflammatory diseases, with special emphasis on PFAPA.

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“…Hence, the proposed Galectin-3 binding to lubricin 32 are likely to only fine-tune the boundary lubricating glycosurface of the joint. In regards of galectin-3 level in SF, it has also been shown that patients with RA have increased level of galectin-3 46,47,48 , while the literature is less conclusive about the situation in OA. Our data shows that compared to the normal SF, the galectin-3 levels are diminished in late stage OA.…”

Section: Truncation Of Sf Lubricin O-glycosylation In Oa and Galectin-3mentioning

confidence: 99%

Core-2O-glycans are required for galectin-3 interaction with the osteoarthritis related protein lubricin

Ali

et al. 2019

Preprint

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Author contributions: SA planned and executed the glycomic analysis, KT and LA planned and executed the glycoproteomic analysis, SH performed ELISA analysis, SR performed SPR analysis, YM and JH designed the recombinant expression and experiments executed by YM. OR, LB, RK, TS and TE were responsible for control and patient sample collection. TS and GJ contributed with design and provision of rhPRG4 for the analysis, MS and AK participated in planning and supervision of galectin-3 experiments. SF, KT and NK performed the writing with input from all contributors. NK coordinated and directed the research. All authors signed off on the final version.ABSTRACT Synovial fluid lubricin (proteoglycan 4) is a mucin-type O-linked glycosylated (60% of the mass) biological lubricant involved in osteoarthritis (OA) development. Lubricin has been reported to be cross-linked by synovial galectin-3 on the lubricating articular surface. Here, we confirm that binding to galectin-3 depended on core-2 O-linked glycans, where surface plasmon resonance of a recombinant lubricin (rhPRG4) devoid of core-2 structures lacked binding capacity to recombinant galectin-3. Both galectin-3 levels and interactions with synovial lubricin were found to be decreased in late-stage OA patients coinciding with an increase of truncated and less sialylated core 1 O-glycans. These data suggest a defect cross-linking of surface active molecules in OA and provides novel insights into OA molecular pathology.

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Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression

Abstract: These results suggest that serum levels of galectin-3 are increased in active JIA children and galectin-3 can be a new biomarker indicating JIA disease activity, severity and progression, although its increment is not disease-specific.

Cited by 33 publications

References 19 publications

Galectin-3: A Potential Biomarker of Rheumatic Diseases

Galectin-3: A Potential Biomarker of Rheumatic Diseases

Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome

Core-2O-glycans are required for galectin-3 interaction with the osteoarthritis related protein lubricin

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