Elevated resistin opposed to adiponectin or angiogenin plasma levels as a strong, independent predictive factor for the occurrence of major adverse cardiac and cerebrovascular events in patients with stable multivessel coronary artery disease over 1-year follow-up

Abstract

SummaryBackgroundAdipokines such as adiponectin and resistin, as well as angiogenin, may be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic value of these adipokines in patients with stable multivessel coronary artery disease (MCAD).Material/MethodsThe study group comprised 107 MCAD patients (74% males, mean age 63±8 years). Adiponectin, resistin and angiogenin plasma levels were measured at admission and after 1-year follow-up. Primary end point (major adverse cardiac and cerebrovascular events – MACCE) was defined as cardiac death, nonfatal myocardial infarction, stroke, and hospitalization for angina or heart failure over a 1-year period.ResultsAfter 1-year follow-up, 9 (8%) patients died, all from cardiovascular causes. Primary end point was experienced by 32% of patients. Surgical treatment (CABG) was received by 51% of patients, while 49% were treated medically alone. Total cholesterol concentration levels ≥173 mg/dl were associated with a 7-fold increase (OR 7.3; 95% CI, 1.6–33.0); LDL ≥93.5 mg/dl with a 16-fold increase (OR 16.3; 95% CI, 2.8–93.8), and resistin ≥17.265 ng/ml with a 13-fold increase in MACCE risk (OR 13.5; 95% CI, 2.3–80.3). In multivariate analysis, a medical treatment strategy (p=0.001), a higher CCS class (p=0.004), resistin levels (p=0.003) and a higher Gensini score (p=0.03) were independent predictors of MACCE.ConclusionsIn stable patients with MCAD, elevated plasma resistin (as opposed to adiponectin or angiogenin) is a strong, independent predictive factor for the occurrence of MACCE over 1-year follow-up.

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

“…However, Kreçki et al, revealed the presence of a positive correlation between serum resistin in human subjects and the risk level for the development of CVDs (53). McManus et al showed that resistin concentrations were inversely related to LVFS (54).…”

Human resistin in cardiovascular disease

“…Serum resistin levels showed a stepwise increase with the number of >50% stenosed coronary vessels in patients with stable CAD ). Furthermore, resistin was an independent predictor of major adverse cardiovascular events, including cardiovascular death and myocardial infarction and restenosis in patients undergoing percutaneous coronary intervention Krecki et al, 2011;Momiyama et al, 2011). In addition to these association between resistin and stable coronary artery diseases, elevated plasma resistin level was suggested to predict the development of myocardial infarction in a case-cohort study of 26,490 middle-aged subjects from the European Investigation into Cancer and Nutrition-Potsdam Study without history of MI or stroke with a relative risk of 2.09, adjusted for CRP (Weikert et al, 2008).…”

Plasma levels of resistin predict cardiovascular events

“…In patients with stable multivessel coronary artery disease, Krecki et al (42) found that elevated plasma resistin was a strong, independent predictive factor for the occurrence of major adverse cardiac and cerebrovascular events. Although in some studies plasma levels of resistin were correlated with mortality (43)(44)(45), in most prospective clinical studies resistin fails to appear as an independent risk factor for cardiovascular events and mortality (46)(47)(48)(49).…”